Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[werefckd]

In my book, having a website without any results to show is what makes a company look a lot sketchy. And so far, I have been proven right more than once unfortunately.

I agree

 

[trialAcc]

True, but did hope med readily raise 60 million though? What if, for example, that sum is not actually in the bank, but is committed money that investors are willing to transfer only after certain milestones are achieved by the company? We are talking about a foreign private company that doesn’t even have a website after all. Things can easily get sketchy.

Yes, they raised 60 million, as in they were literally handed a cheque/wire/whatever for operations in exchange for a percentage of ownership of their company. Milestones would be applicable to partnership or licensing agreements like the one they have with Bayer.

 

[werefckd]

Yes, they raised 60 million, as in they were literally handed a cheque/wire/whatever for operations in exchange for a percentage of ownership of their company. Milestones would be applicable to partnership or licensing agreements like the one they have with Bayer.

Let’s hope so

 

[RolfLeeBuckler]

No. Bayer developed the drug for endo. They tested it in mice and found out accidentally that it grew hair. Rui-Ping Xiao was working with Bayer and convinced them to let her try it on her monkeys for hair loss. They agreed, and after it successfully grew hair in the monkeys she founded HMI to purchase the rights to market the drug. Bayer was only interested in endo and breast cancer because they are focused on treating women's health issues, but HMI was more interested in Androgenetic Alopecia because that's where the drug showed the most promise.

Now after 2021 comes to an end we can summarize that HopeMedicine failed terribly in their plans to do clinical trials for HMI-115 against Androgenetic Alopecia. They claimed last year that the pandemic wouldnt have dramatic effects on their timeline and that they are on track to start clinical trials in europe, australia an USA against hair loss.

They received a big investment in May 2021 (60 Mio. $). They changed CEO Rui-Ping to Henri Nico Doods.

Unfortunately we are now aware that HopeMedicine prefers the Endometriosis treatment over the alopecia treatment.
They weren't able to start their alopecia trial. I know some members here will say that HopeMedicine has no influence on the timelines of the FDA or the COVID-situation BUT I am convinced that HopeMedicine should be experienced enough to think about the risks of their timeline in respect to FDA-approval and then shouldnt make claims that they would start the trials in summer 2021...

It is questionable whether Hopemedicine starts in 2022 with the alopecia trial or is now focused in finishing the endometriosis trial which will take until end of 2023. Maybe they want to check up this risk profile before starting the alopecia trial

After all this encouraging discussion in this thread regarding HMI-115 and its very exciting results (monkey pictures) it let me down to an huge dissapointment and a very bad year for hairloss industry 2021...

 

[Ollie]

Now after 2021 comes to an end we can summarize that HopeMedicine failed terribly in their plans to do clinical trials for HMI-115 against Androgenetic Alopecia. They claimed last year that the pandemic wouldnt have dramatic effects on their timeline and that they are on track to start clinical trials in europe, australia an USA against hair loss.

They received a big investment in May 2021 (60 Mio. $). They changed CEO Rui-Ping to Henri Nico Doods.

Unfortunately we are now aware that HopeMedicine prefers the Endometriosis treatment over the alopecia treatment.
They weren't able to start their alopecia trial. I know some members here will say that HopeMedicine has no influence on the timelines of the FDA or the COVID-situation BUT I am convinced that HopeMedicine should be experienced enough to think about the risks of their timeline in respect to FDA-approval and then shouldnt make claims that they would start the trials in summer 2021...

It is questionable whether Hopemedicine starts in 2022 with the alopecia trial or is now focused in finishing the endometriosis trial which will take until end of 2023. Maybe they want to check up this risk profile before starting the alopecia trial

After all this encouraging discussion in this thread regarding HMI-115 and its very exciting results (monkey pictures) it let me down to an huge dissapointment and a very bad year for hairloss industry 2021...

Dude even if the hair treatment was an instant cure they’d still go for endometriosis first. No insurance company is paying anyone a dime for a hairloss treatment and with the price of antibody treatments privately not a huge amount of people are paying that price. The application to hairloss will come but it won’t ever be prioritised when there’s no certainty of recouping investment quickly.

 

[pegasus2]

Now after 2021 comes to an end we can summarize that HopeMedicine failed terribly in their plans to do clinical trials for HMI-115 against Androgenetic Alopecia. They claimed last year that the pandemic wouldnt have dramatic effects on their timeline and that they are on track to start clinical trials in europe, australia an USA against hair loss.

They received a big investment in May 2021 (60 Mio. $). They changed CEO Rui-Ping to Henri Nico Doods.

Unfortunately we are now aware that HopeMedicine prefers the Endometriosis treatment over the alopecia treatment.
They weren't able to start their alopecia trial. I know some members here will say that HopeMedicine has no influence on the timelines of the FDA or the COVID-situation BUT I am convinced that HopeMedicine should be experienced enough to think about the risks of their timeline in respect to FDA-approval and then shouldnt make claims that they would start the trials in summer 2021...

It is questionable whether Hopemedicine starts in 2022 with the alopecia trial or is now focused in finishing the endometriosis trial which will take until end of 2023. Maybe they want to check up this risk profile before starting the alopecia trial

After all this encouraging discussion in this thread regarding HMI-115 and its very exciting results (monkey pictures) it let me down to an huge dissapointment and a very bad year for hairloss industry 2021...

You have a weird definition of failed terribly. They applied for both trials. The endo trial got approved already, the hair loss trial could get approved any day. Chill out. Being behind a few months in the biotech world is actually a success not a "terrible failure".

 

[trialAcc]

You have a weird definition of failed terribly. They applied for both trials. The endo trial got approved already, the hair loss trial could get approved any day. Chill out. Being behind a few months in the biotech world is actually a success not a "terrible failure".

You're feeding the trolls right now, why bother? It's clear that the person you are responding to doesn't have a clue what he's talking about.

 

[werefckd]

You have a weird definition of failed terribly. They applied for both trials. The endo trial got approved already, the hair loss trial could get approved any day. Chill out. Being behind a few months in the biotech world is actually a success not a "terrible failure".

Do we know for a fact that they applied for both trials and not just for endometriosis?

 

[trialAcc]

Do we know for a fact that they applied for both trials and not just for endometriosis?

Probably, because they have said it like 5 times now...

 

[werefckd]

Probably, because they have said it like 5 times now...

I haven’t caught that. Where did they say it?

 

[trialAcc]

I haven’t caught that. Where did they say it?

They've said they intended to launch the Androgenetic Alopecia trial in the summer. Considering the process is like a 90 day waiting period, fair to assume they submitted the IND at some point.

 

[Dimitri001]

Now after 2021 comes to an end we can summarize that HopeMedicine failed terribly in their plans to do clinical trials for HMI-115 against Androgenetic Alopecia. They claimed last year that the pandemic wouldnt have dramatic effects on their timeline and that they are on track to start clinical trials in europe, australia an USA against hair loss.

They received a big investment in May 2021 (60 Mio. $). They changed CEO Rui-Ping to Henri Nico Doods.

Unfortunately we are now aware that HopeMedicine prefers the Endometriosis treatment over the alopecia treatment.
They weren't able to start their alopecia trial. I know some members here will say that HopeMedicine has no influence on the timelines of the FDA or the COVID-situation BUT I am convinced that HopeMedicine should be experienced enough to think about the risks of their timeline in respect to FDA-approval and then shouldnt make claims that they would start the trials in summer 2021...

It is questionable whether Hopemedicine starts in 2022 with the alopecia trial or is now focused in finishing the endometriosis trial which will take until end of 2023. Maybe they want to check up this risk profile before starting the alopecia trial

After all this encouraging discussion in this thread regarding HMI-115 and its very exciting results (monkey pictures) it let me down to an huge dissapointment and a very bad year for hairloss industry 2021...

We shouldn't be waiting with baited breath for HMI. Even if they hit all the checkpoints according to schedule (and there can always be delays), access to the actual antibody will still be far away in time and, likely, expensive. Better to focus on experimenting with SMI.

Maybe you can get the same effect or similar to what the monkeys got RIGHT NOW with the right dose and frequency of application of SMI.

Furthermore, the antibody may be so pricey once it is out that people might still want to turn to SMI - better to start getting the necessary experimentation done now.

 

[fashy]

I'm pretty sure almost everyone has given up on SMI tbh. Don't see it becoming a viable alternative when no one wants to experiment with it anymore.

 

[froggy7]

invest in cryonics, we wont have cure in our lifetime, it is too complicated

 

[Dimitri001]

I'm pretty sure almost everyone has given up on SMI tbh. Don't see it becoming a viable alternative when no one wants to experiment with it anymore.

Aren't the Discord guys still using SMI? I thought there was a new group buy recently.

 

[Redgate]

I'm struck by how all these "cure" threads over the years look the same - wild speculation and optimism from limited or questionable information

I can't imagine getting fooled for literally years on end by press releases and patent claims and not becoming at least a little more conservative in my statements, if only to maintain a shred of credibility View attachment 174180

HMI has results that are far better than anything that isn't cloning, is being trialed for another, insurance-covered indication and is backed by a big pharma company, that can easily get a drug to market within 5-6 years. Based on this concrete information, we can make reasonable speculations.

 

[pegasus2]

I'm struck by how all these "cure" threads over the years look the same - wild speculation and optimism from limited or questionable information

I can't imagine getting fooled for literally years on end by press releases and patent claims and not becoming at least a little more conservative in my statements, if only to maintain a shred of credibility View attachment 174180

You're obsessed with me

 

[pegasus2]

invest in cryonics, we wont have cure in our lifetime, it is too complicated

Of course we will, but timelines are uncertain, and delays are normal. RIKEN's hair cloning project got thrown off by covid causing their partner to go bankrupt. They still have a working cure, and they will get it into human trials at some point. HMI-115 could very well cure hair loss, but only time will tell. Whether it's a more effective treatment or a cute, it is likely that it will make it to market. We are also getting closer to figuring out what causes hair loss, and there are drugs being developed now that can target these mechanisms. It is highly likely that Androgenetic Alopecia will be effectively cured in the coming decade. Access to it may take longer, but if HMI is the cure then 2025 is not unrealistic

 

[pegasus2]

Just do nothing until a cure shows up at the pharmacy. Ok, let's close down the new research section

 

[John Difool]

Mann fell into the crowd of overthinking it, being a hypochondriac, and delaying treatment until he needed hair transplants.

He would have fit really well into this thread of trying to read the tea leaves and figuring out when the "real" cure was coming out

The one person who doesn't fit in here at all is you and that doesn't stop you from posting the same salad everyday.