Posting this human study again for the people who have forgotten about it or never read the whole thread. Some Canadians claim that experimenting with sulforaphane(broccoli sprouts) is more scientifically valid than PRLR antagonists, but there is zero indication in the scientific literature that sulforaphane or NRF2 is responsible for the pattern of hair loss found in Androgenetic Alopecia. There is for prolactin. That's not to say that NRF2 activation isn't helpful, but it is not a lack of NRF2 activation that causes Androgenetic Alopecia so it cannot cure it.
"PRL represents a promising candidate gene for the hair growth defects observed in Androgenetic Alopecia-affected HFs. Moreover, PRL stimulates adrenal androgen production and elevated PRL levels have been reported to be accompanied by hirsutism and hair loss from the scalp, which resembles the pattern observed in Androgenetic Alopecia.[
74-
76] Also notable in the context of Androgenetic Alopecia is the observation of sex- and location-dependent hair growth regulatory effects for PRL in studies of human
ex vivo HFs.
While PRL promoted hair growth/hair shaft elongation in HFs derived from female frontotemporal scalp, PRL treatment of isolated male occipital scalp HFs resulted in premature catagen induction and thus the inhibition of hair growth.[77] This observation has been further substantiated on a molecular level, since PRL treatment resulted in sex‐ and site‐specific differences in gene expression.[77] Furthermore, analyses of plucked HFs from male frontal and occipital scalp revealed differential expression for several microRNAs (miRNAs) that target PRL signalling.[64] Together, these findings suggest that PRL action may contribute to the observed differences in Androgenetic Alopecia susceptibility between frontal and occipital HFs and the resulting characteristic hair loss pattern"
onlinelibrary.wiley.com
While I think that broccoli sprouts are too weak to be of any use, I do think more potent NRF2 activators are worthwhile. It improves both hair and skin. I posted this patent last year for oltipraz:
"Fibroblast population in the dermis of the Oltipraz treated group was significantly higher than that of the control and vehicle groups.
Fibroblast population in Oltipraz treated group was reported 92.29% higher than the controls (
p=0.003) and 104.25% higher than the vehicle group (
p=0.003).The
volume density of the collagen bundles was 38.03% and 57.75% higher in the oltipraz treated group compared to the control and the vehicle groups, respectively, which both were statistically significant (
p<0.001). Consequently, the
volume density of hair follicles was higher in the oltipraz group in comparison to the control (66.1%; P=0.043) and the vehicle (210%;
p=0.001) groups"
https://patents.google.com/patent/KR101165648B1/en
I think it's more useful for hair pigmentation than hair growth, but it should help both.