Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[Big A]

Do we have a clear timetable for HMI?

 

[pegasus2]

Almost doubling hair density is really nothing for an area that is already bald. If you go from 4 hairs/cm2 to 8 hairs/cm2 in an area that you used to have 100+ hairs/cm2 it doesn’t mean anything. So I hope that info is not accurate (and according to the pictorial results of those macaques I think the density virtually got much better)

I think this is explained by the fact that they called very short and thin hairs terminal hairs, hairs that we would typically call intermediate. All of those hairs grew to full thickness, and the vellus hairs too. The number of fully terminal hairs appears to have increased by a thousand fold

 

[trialAcc]

Almost doubling hair density is really nothing for an area that is already bald. If you go from 4 hairs/cm2 to 8 hairs/cm2 in an area that you used to have 100+ hairs/cm2 it doesn’t mean anything. So I hope that info is not accurate (and according to the pictorial results of those macaques I think the density virtually got much better)

Pretty sure the areas classified as "bald" on the macaques still grew terminals in the triple digits, they just have more vellus then humans to start with so it's tough to predict what will happen I guess.

 

[Nehel]

That sh*t is only going to be for millionaires.

If you're not, don't be too hyped.

 

[Jackshtbro]

That sh*t is only going to be for millionaires.

If you're not, don't be too hyped.

Cope, Neil Armstrong gets a discount

 

[pegasus2]

Cope, Neil Armstrong gets a discount

Buzz Aldrin too

 

[Jackshtbro]

Buzz Aldrin too

No doubt. Lucky bastards.

 

[Nehel]

If humor allows you to deny reality, good for you, stay in your denial my baldies.

 

[pegasus2]

If humor allows you to deny reality, good for you, stay in your denial my baldies.

I am certain it won't cost more than what I can afford. For everyone else, maybe dNovo in ten years will be cheap.

 

[Nehel]

Maybe, but that's probably not the case for the majority here.

 

[Dimitri001]

Damn, some of you lucky Yanks might get the treatment for free! I hope someone can get in, so we can have an informant.

 

[pegasus2]

Clearly the better business case can be made for running an endo phase II trial, using those results to get more funding, and then running trials for hair loss or other indications with a safety net such that the whole company doesn't fail from one bad outcome.

Biotech moves really slow, nothing unusual in the timeline of events so far. Even large pharma companies usually prioritize a single indication when pushing a drug until at least phase III, and that's with vastly more resources and experience than this company has.

(and that's all without knowing what's actually happening behind the scenes - it's still not clear if regulatory bodies will force them to do a phase I in men or let them do some kind of combined phase I/II)

You might want to email this to Henri Doods so he knows he's making a terrible mistake pursuing Androgenetic Alopecia and endo at the same time

 

[pegasus2]

For all intents and purposes in the context we care about here, this drug is still preclinical - we could literally have a human on Mars before this is available

so even though it's exciting...it might be smarter to manage your expectations about any single treatment vs being excited about the dozens of other preclinical treatments that could pay off

Here's some wild speculation (since that's the theme of the thread):

It could be the case that their relatively faster progress on phase I/II trials in women only signals that they're looking at it their product development much more sequentially than is being hoped here

ie get it near the end of phase III for endometriosis first, and only then move forward seriously on phase II for Androgenetic Alopecia

If there's obvious progress on the Androgenetic Alopecia side in a couple years, then I'm wrong about that (e.g. they're past the phase II subject recruitment stage)

this pattern would also be very similar to how finasteride itself was developed - despite knowing 100% it would also work for Androgenetic Alopecia, they waited until it was approved and in use for the prostate (and their investment recouped) before moving forward to get it approved for that 2nd indication (5 full years extra)

It seems they are more interested in pursuing Androgenetic Alopecia than you thought

 

[Baldingtooyoung]

This was the insane expensive drug right?

 

[John Difool]

Any pointer for Australia?

 

[pegasus2]

Any pointer for Australia?

ClinicalTrials.gov

www.clinicaltrials.gov

 

[RolfLeeBuckler]

ClinicalTrials.gov

www.clinicaltrials.gov

the status of the endo trial is "Not yet recruiting".
So can we assume that they didnt even started recruiting for this trial?
I checked the "Tidewater Clinical Research" and under Endometriosis - tidewaterclinresearch.com they have a clinical trial with Endo. I think this is the trial of HopeMedecine - dont you think so?

It seems like they didnt updated the clinicaltrials.gov site.

 

[pegasus2]

the status of the endo trial is "Not yet recruiting".
So can we assume that they didnt even started recruiting for this trial?
I checked the "Tidewater Clinical Research" and under Endometriosis - tidewaterclinresearch.com they have a clinical trial with Endo. I think this is the trial of HopeMedecine - dont you think so?

It seems like they didnt updated the clinicaltrials.gov site.

It just hasn't been updated.

 

[Will Be an Egg in 5 years]

So, should I be hyped up or not?

 

[trialAcc]

an IND literally just requires the investigator to file a status report once a year, and only becomes inactive if they don't start recruiting for a trial within 2.

Even after 2 years an extension can simply be filed to keep it active https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=312.45

An IND was a given, unless you thought they had completely abandoned pursuing Androgenetic Alopecia (which I didn't)
Nothing has really been clarified on their business plan or timeline

Sure it has...they said they planned to start the trial last year. Based on what just occurred, it's pretty damn clear that it took the FDA longer to approve this trial then the endo one. The trial will launch on the site within a few weeks and they will start recruiting this spring.

You just keep moving the goal posts over there.