MindfluX, your last post was really interesting in regards to the EP3 and EP4 receptors, especially because most posters online mention that castor oil hits only one out of the four PGE2 receptors. After completely reading the study you posted, I'm glad to hear it hits 2 out of the 4!
I wonder if that combined with dinoprostone PGE2 gel might work well together.
Now regarding transdermals... out of DMSO, ethanol, DIM etc. The best one I have found is called Salvo by Iron Legion. I had copy and pasted the science and ingredients in it, but I can't post it for some reason. A warning pops up that my message has spam like elements.
All I will say is that I notice that I have less dry/flakey residue left on my skin after I use it with various powders, which indicates that it absorbs pretty well, and the reviews on bodybuilding forums have been great.
Some info:
The intercellular lipids of the stratum corneum are regarded as the major barrier to the permeation of lipophilic compounds. Salvo contains potent ingredients which modulate this lipid matrix & affect the non-polar permeation-enhancement route. These ingredients include thiazone, which is 3-12x more potent than azone as a permeation-enhancer for lipophilic molecules, and nerolidol, a lipophilic terpene which has been shown to be highly effective at facilitating the delivery of lipophilic molecules. It also includes oleic acid and stearyl methacrylate, fatty-acid derivatives which insert themselves between the hydrocarbon tails of intercellular stratum corneum lipids, and which thus disrupt lipid packing, increase fluidity, and promote diffusion through the external layer of the stratum corneum.
Salvo utilizes a volatile:nonvolatile co-solvent vehicle to create a state of supersaturation, which helps compounds cross the exterior layers of the stratum corneum. As the volatile component evaporates on your skin, the solution becomes more concentrated, and eventually becomes super-saturated, resulting in increased thermodynamic ‘push’, and enhanced penetration.
is generally compatible with active ingredients that have LogP values of 1.5-4.0. Salvo’s system is designed for use with lipophilic ingredients, does not affect the polar route of stratum corneum permeation, and thus compounds with lower lipophilicity will not partition adequately into the SC lipids. Compounds with LogP values higher than 4.0 might have such high affinity for those same SC lipids that they accumulate there & don’t reach the lower levels of the epidermis at reasonable concentrations. -Molecular weight is a good indicator of chemical surface area, which is directly related to diffusion coefficient. As such, compounds with a MW >500 are not expected to work well in this topical system. -’Melting point’ is an indicator of solubility in skin lipids. In general, compounds with low melting points are more compatible with topical solutions than compounds with high melting points. -Ionized species will permeate less readily than free acid forms.
I wonder if that combined with dinoprostone PGE2 gel might work well together.
Now regarding transdermals... out of DMSO, ethanol, DIM etc. The best one I have found is called Salvo by Iron Legion. I had copy and pasted the science and ingredients in it, but I can't post it for some reason. A warning pops up that my message has spam like elements.
All I will say is that I notice that I have less dry/flakey residue left on my skin after I use it with various powders, which indicates that it absorbs pretty well, and the reviews on bodybuilding forums have been great.
Some info:
The intercellular lipids of the stratum corneum are regarded as the major barrier to the permeation of lipophilic compounds. Salvo contains potent ingredients which modulate this lipid matrix & affect the non-polar permeation-enhancement route. These ingredients include thiazone, which is 3-12x more potent than azone as a permeation-enhancer for lipophilic molecules, and nerolidol, a lipophilic terpene which has been shown to be highly effective at facilitating the delivery of lipophilic molecules. It also includes oleic acid and stearyl methacrylate, fatty-acid derivatives which insert themselves between the hydrocarbon tails of intercellular stratum corneum lipids, and which thus disrupt lipid packing, increase fluidity, and promote diffusion through the external layer of the stratum corneum.
Salvo utilizes a volatile:nonvolatile co-solvent vehicle to create a state of supersaturation, which helps compounds cross the exterior layers of the stratum corneum. As the volatile component evaporates on your skin, the solution becomes more concentrated, and eventually becomes super-saturated, resulting in increased thermodynamic ‘push’, and enhanced penetration.
is generally compatible with active ingredients that have LogP values of 1.5-4.0. Salvo’s system is designed for use with lipophilic ingredients, does not affect the polar route of stratum corneum permeation, and thus compounds with lower lipophilicity will not partition adequately into the SC lipids. Compounds with LogP values higher than 4.0 might have such high affinity for those same SC lipids that they accumulate there & don’t reach the lower levels of the epidermis at reasonable concentrations. -Molecular weight is a good indicator of chemical surface area, which is directly related to diffusion coefficient. As such, compounds with a MW >500 are not expected to work well in this topical system. -’Melting point’ is an indicator of solubility in skin lipids. In general, compounds with low melting points are more compatible with topical solutions than compounds with high melting points. -Ionized species will permeate less readily than free acid forms.
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