Depends on whether the creme can penetrate as deeply through the scalp. Are sebaceous glands closer to the skin than hair follicles?
If the compound can reach deep enough then it should work provided the dosage is sufficient.
If not, then you would need to extract the CB through chemical processes and make your own vehicle which you can already do, IMO not worth. But maybe it would be a lot cheaper than now.
Since switching over to CB from RU. I've noticed the CB works even better on the hairline. I'm seeing some nice improvement. Using the same dosage 50mg daily.