CB causes sexual side effects?!

[WangMQ]

yes sure they did. 8hrs in vitro blood. around 20 mins in vivo i guess.

20 mins in vivo?? How is it supposed to work with that rate anyway

 

[hilbert]

20 mins in vivo?? How is it supposed to work with that rate anyway

what do you mean?
cb either binds to ARs (and stays there for its sourmounting time, which i don't know but i suppose is hrs), or its metabolized into 21-a-p then cortexolone (and it goes to 21-a-p quite quickly afaik)..

 

[WangMQ]

what do you mean?
cb either binds to ARs (and stays there for its sourmounting time, which i don't know but i suppose is hrs), or its metabolized into 21-a-p then cortexolone (and it goes to 21-a-p quite quickly afaik)..

Thanks for that hilbert. I thought 20 mins was too short to have any effect hair wise. But now that it will stay on ARs as soon as it binds to them that won't be a problem anyway.

 

[hilbert]

Thanks for that hilbert. I thought 20 mins was too short to have any effect hair wise. But now that it will stay on ARs as soon as it binds to them that won't be a problem anyway.

it's the principle of every anti-AR. what happens to the unbound quota makes the difference at the level of systemic effects.