Now we're getting somewhere gents -- enjoying the exchange.
For my part I'm desperate enough to try. If there's a chance at crown regrowth without finasteride sides I'll give it a shot.
First question: do any of you that are more knowledgeable about skin layers, molecular weight, daltons, etc. have an opinion about the underlying theory that a topical dutasteride will somehow not be absorbed systemically the way topical finasteride is?
I received this topical dutasteride, lipsomal at 0.5%. I’m planning to wait a total of 4 weeks after taking my last finasteride dose to confirm that side effects subside (has worked in the past) then get detailed lab work to get a sense of baseline T, DHT, and everything else.
Second question: Having looked at a lot of dutasteride experiences on here, a significant number of people seem to think that dutasteride is effective on the crown but ineffective or possibly even damaging on the hairline. The thought occurred to me to begin by just applying to the crown and not the hairline. What do we know about the whole “dutasteride shreds the hairline” thing? Wives tale? Valid concern?
I was also planning to continue microneedling weekly or biweekly at ~1-1.5mm, but would make sure to wait ~3 days after topical dutasteride application. Bad idea? I’m hoping this will not increase systemic absorption but I’m in broscience territory here.
Appreciate any thoughts/theories.