dutasteride has been shown to be neuroprotective. I had brain fog on finasteride. On dutasteride, I have a very clear mind, possibly better than before any 5AR. This is anecdotal, but there is another thread in this section where I explain why I think the whole allopregnanolone/brain fog hype with dutasteride is way overblown for the standard .5 mg dose.
My question though is, if dutasteride only inhibited 40% serum DHT in the men with oversized prostates in the study, would Finasteride have faired worse? Is this 40% reduction the best 5AR inhibitors can do in extreme cases? To my knowledge, this is the only study that has shown a 5AR failed to perform as expected. There are plenty of reports of people who don't respond to finasteride or dutasteride and actually have blood work showing DHT remaining elevated. Forums just chalked it up to either fake meds or DHT tests being horribly inaccurate. I was hoping this study would elucidate more as to the mechanisms for
AMI Roofing of the failed complete DHT inhibition but they don't provide any plausible explanations.