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Without 5ar-enzymes on our scalp the sebaceous gland is innoperative, my question is: how
flexible and lustrous would be our hair? mummy type?
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flexible and lustrous would be our hair? mummy type?
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CRISPR/Cas9 Therapy For Androgenic Alopecia by Moogene Medi
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Gene editing is done at NIH for cancer treatments for last 20 years at least. We still have cancer. But what they are trying is to use a topical, encapsulated in bubbles, burst it with ultrasound? and thus edit the androgen receptors to be immune from DHT damage. Great hypothesis.. But does this work, is it efficacious?
The trial and error in connection with inhibiting DHT versus blocking all androgens has already been done. Blocking all androgens works better than only inhibiting the one androgen - DHT. This has been known for a long time. The researchers involved with this project are fools. It's so predictable what will happen. They will literally waste 5 - 10 years running their gene-editing DHT inhibiting technology through trials, get mediocre results, and then publicly say, "Now we're going to try using gene-editing to block all androgens in the scalp instead of just DHT because we think we could get better results if we block all androgens instead of only inhibiting DHT." What a bunch of jackasses.
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Even if this effort to impact on DHT works it will only work on ONE androgen - DHT. It won't work on the other androgens. So there will still be androgens binding to androgen receptors in your scalp and hair growth benefit will be limited. In order to get better results you need to block all androgens, not just one.
This is why smart companies are working on androgen receptor blockers like CB even though 5AR inhibiors have been on the market for a long time. his Korean group is showing what fools they are because they're going back to the 1990s and focusing on only DHT whereas everyone else has figured out that they need to focus on the androgen receptor so they can negate all androgens in the scalp. They have their heads up their asses.
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Do you think covid might help as well? I have some google news alerts for "androgens" and I keep seeing a few articles stating that prostate treatment may also be beneficial for COVID as it blocks the androgrens.
Good point being made that DHT is only one androgen that does/could affect male pattern baldness. What are other androgens that do or could affect male pattern baldness? And what are the counters?
I have been looking at clinical data available on topicals/ essential oils, but haven’t paid enough attention on what androgens they block.
I have been looking at clinical data available on topicals/ essential oils, but haven’t paid enough attention on what androgens they block.
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Gene editing the Androgen Receptor with Crispr-interface LACE (light activated) system is the most promising.
That's not how it works. There is no tradeoff, but if there was I would happily sacrifice my beard for hair.
Or is it that AR antagnoists block ALL DHT in the scalp instead of just 40% of it.
Except we don't, because even the strongest one, dutasteride, only reduces scalp DHT by 60%~. At least this would likely work for everyone.
So what's your point? It sounds like you want them to put more time into 5-alpha reductase inhibitors, which only reduce dht, even though androgen receptor-blockers, which negate all androgens, work better and even though we've had 5-alpha reductase inhibitors for awhile and we aren't satisfied with them.
Great!
Fortunately for you, Cassiopea is on board with the thinking of guys like me and disinterested in what guys like you are saying. You'll get a breakthrough treatment for hair loss sooner because companies, like Cassiopea, are on board with what the guys like me and ignoring guys like you.
I've put you on ignore because you drag the discussion backwards into the past instead of moving the discussion forward. Smart men already have already learnt that a potent androgen-blocker is better than a potent drug that only works on DHT because a potent androgen-blocker negates more androgen. DHT isn't the only androgen homie.
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You've put me on ignore because I stated a simple fact? You have some issues man.
You are missing the point. Using finasteride/dutasteride only inhibits 40%-60% of scalp DHT. So maybe this does not work for everyone because there is still scalp DHT left? That is basically what Moogi Medi is betting on. Or (your point) other androgens are the cause. We simply don't know
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But T isn’t solely converted to DHT locally in the dermal papilla cells? By only reducing 5-ar in the scalp, won’t free DHT in the blood wreck havoc on the hair follicles?
Bzzt!!!! Wrong. The other androgens also bind to androgen receptors, just like DHT does, and it's likely they also play a role in hair loss since they're also androgens, the same as DHT.
RU58841 block all types of androgens @ the receptor site and it's more effective than 5ar inhibitors.
You're on ignore for your backwards thinking. Fortunately for you Cassiopea & kintor drug companies aren't interested in your backwards thinking and they're moving forward with their androgen-receptor blockers.
You don't know but I do.
and ultimately it doesn't matter genius because if you block all androgens in the scalp (like I want to) that means you will also block all DHT anyway whereas if you only negate DHT (like you want to) then the remaining androgens will still be able to take your hair *if *they have that power, genius. Why take chances, genius? Why not do the smart thing and negate all of the androgens in the skin of your scalp, genius?
You're on ignore for being a fool
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Improvement in scalp hair growth in androgen-deficient women treated with testosterone: a questionnaire study
Testosterone stimulates cell proliferation, and induces hair growth everywhere else on the body. Might it be that we actually want a small amount of testosterone rather than none?
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