Curis, P&g, And The Lost Baldness Cure

[Dimitri001]

Itraconazole, a commonly used anti-fungal that inhibits Hedgehog pathway activity and cancer growth

In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a mechanism distinct from its inhibitory effect on fungal sterol biosynthesis. ...

www.ncbi.nlm.nih.gov

mrOscar sent me this study. I'm reevaluating the use of ketoconazole.

Haven't read the full study, but it's about itraconazole, not ketoconazole. Or are the results presumed to be similar with keto?

At any rate, the mechanistic knowledge is valuable, but as far as claims that keto may be detrimental to hair growth, empirical studies that show the opposite is true trump mechanistic arguments.

 

[ElToso]

It is of interest that ketoconazole, another azole antifungal, has been used as second line therapy for androgen independent metastatic prostate cancer (Scholz et al., 2005; Trump et al., 1989) at doses 3–6 fold higher than its normal dose and with toxicities greater than those for high-dose itraconazole (Sugar et al., 1987). The use of ketoconazole in this context is believed to act by inhibiting androgen production, but we cannot rule out the possibility of an effect on Hh pathway activity.

It's just a hypothesis

 

[DavidsDome]

any updates from the SAG users?