Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

[ImpedingReceding]

Article:

Innovative hair loss treatment can restore 90% of lost hair

This could be great news for millions of people around the world.

www.zmescience.com

The study

https://www.science.org/doi/10.1126/sciadv.aba1685

Summary:


”Researchers have developed a new hair loss treatment using dermal exosomes, which can restore up to 90% of lost hair in mice. This innovative approach involves using exosomes from dermal papilla cells to reactivate hair follicles and stimulate hair growth. If successful in humans, it could revolutionize current hair loss treatments.”

So what do you think? Any potential or the same sh*t as always where the mice are super responsers to anything

 

[Dave721]

Isn't DP cell replication what Replicell was all about? I don't remember hearing about exosomes though.

 

[Armando Jose]

Sadly, in mice again "can restore up to 90% of lost hair in mice."

 

[Jakejr]

It appears to be a scalp injection of this hair concoction… Why it can’t be tested in humans I don’t know

 

[resu]

We've been reading these successful tests in mice for years, anything can revert hair in mice.

 

[Dimitri001]

Together, these data support the theory that the main therapeutic pathway involves the stimulation of WNT signaling by miR-218-5p–overexpressed exosomes through a down-regulation of SFRP2, a WNT signaling inhibitor, and up-regulation of β-catenin.

Whenever I read this, my main question is, so what's the cancer potential?

This is kind of interesting:

The expression of β-catenin was up-regulated not only in the injection sites but also in nontreated sites.

Wait, am I reading this correctly? They just shaved the mice, they didn't even apply DHT? Well, that's a pretty lousy model for Androgenetic Alopecia.