Did Anyone Maintain With Setipiprant

[Folliman]

Could care less what Cotsarelis says.

Observations are of importance, Cotsarelis is irrelevant.

Unless you live in a unicorn world.

If you have more than 5+ DP2 antagonists that have ran clinical trials across thousands of people and hair growth hasn't been reported as a side-effect then you simply know they won't induce regrowth.

SIMPLE AS THAT.

Hair growth wasn't reported in the avodart studies either and some users get good results from it

 

[Afro_Vacancy]

Why not just wait for Allergan to release data? Or better yet, volunteer for the trial. You'll get a double blind placebo controlled trial that directly compares against finasteride. It should put many questions to rest...

If I join the trial I have to quit minoxidil, quit RU, and then have a 33℅ chance of either seti, finasteride, or placebo.

No thanks.

 

[rclark]

I'll eat a shoe if setipiprant will get released to the market .

Would you prefer NIKEs or something else?

 

[rclark]

I haven't read of anybody having success with TM30089, or that "OC" treatment.

Have you ever thought of doing both and microdosing finasteride (one half)?

Even every other day?

Has your hair loss stabilized, within the last year?

 

[Swoop]

Hair growth wasn't reported in the avodart studies either and some users get good results from it

Now why you do think that is?

Is it maybe, that finasteride was already approved by that time for hair loss?

The effect was already known by that time of 5ar2 inhibitors.

If every scientist/observant would apply your line of thinking it would be a mess and we would have hundreds of case reports released every day.

Doesn't work like that.

We don't need to report on reinventing the wheel, but we do generally report on "unique" or "new" observations.

 

[Afro_Vacancy]

Have you ever thought of doing both and microdosing finasteride (one half)?

Even every other day?

Has your hair loss stabilized, within the last year?

I have not considered CTRH2 antagonists.

Finasteride is a no-no for me as I already have some depression and ED.

I've had modest regrowth on my regimen.

 

[Folliman]

Now why you do think that is?

Is it maybe, that finasteride was already approved by that time for hair loss?

The effect was already known by that time of 5ar2 inhibitors.

If every scientist/observant would apply your line of thinking it would be a mess and we would have hundreds of case reports released every day.

Doesn't work like that.

We don't need to report on reinventing the wheel, but we do generally report on "unique" or "new" observations.

No. Hair was not mentioned in the proscar studies either.

 

[rclark]

I have not considered CTRH2 antagonists.

Finasteride is a no-no for me as I already have some depression and ED.

I've had modest regrowth on my regimen.

This is personsal, and I really don't expect more than a yes/no response.

Are you treating your depression? Some men are responsive when treated.

But maybe you don't need to. Is it other things that are causing depression, or is it internal
causing external factors?

 

[Afro_Vacancy]

But maybe you don't need to. Is it other things that are causing depression, or is it internal
causing external factors?

The disease is not that well understood.

 

[rclark]

The disease is not that well understood.

Good answer. I wouldn't give a No/Yes response on the Internet either!

 

[KO1]

From the horse's mouth....
The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

http://www.nejm.org/doi/full/10.1056/NEJM199210223271701?query=prevarrow&#t=article

 

[rclark]

From the horse's mouth....
The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

http://www.nejm.org/doi/full/10.1056/NEJM199210223271701?query=prevarrow&#t=article

Speaking for myself, I urinate frequently. I would turn into a leaky water hose if I didn't
use Finasteride, I guess?

I piss more than my dogs do. And one of them is almost SIXTEEN years old.

 

[Swoop]

No. Hair was not mentioned in the proscar studies either.

When MK-906 (finasteride) was synthesized they already knew that it could grow hair. Again it would be reporting on something that was "known".

I suggest you too read this:

https://www.bernsteinmedical.com/medical-treatment/medications/propecia-finasteride/

Myth: Propecia was originally a prostate medication that was found to prevent hair loss.
Fact: Propecia is not a prostate medication that was by chance noted to have a side effect of hair growth, it is a medication that was known since its discovery that it could grow hair.

Also, they were literally planning for FDA approval already for the indication hair loss. They just did it later than BPH, because hair loss was and still is a cosmetic disease.

Finasteride came forth through very proper strong observations not out of "nowhere". Even in the macaque model it had shown to already induce hair growth.

 

[KO1]

The same thing could be said about setipiprant. It's based on observational examples of both bald men who express this as well as mouse models where pgd2 induces Androgenetic Alopecia. With finasteride, they knew it had a good chance of treating Androgenetic Alopecia, but the studies for BPH never reported hair growth as a side effect.

Anyways, I don't see the point of debating something that's going to be objectively decided by a clinical trial.

 

[Swoop]

The same thing could be said about setipiprant. It's based on observational examples of both bald men who express this as well as mouse models where pgd2 induces Androgenetic Alopecia. With finasteride, they knew it had a good chance of treating Androgenetic Alopecia, but the studies for BPH never reported hair growth as a side effect.

Anyways, I don't see the point of debating something that's going to be objectively decided by a clinical trial.

PGD2 hypothesis isn't based on strong observations, but weak observations.

Finasteride was based on extremely strong observations.

Furthermore PGD2 doesn't induce androgenetic alopecia in mice, lol.

BPH wasn't noted as hair growth side effect, no. There was no case report either.

They were already basically engaging into clinical trials for indication hair loss also.

Based on everything it's pretty deluded to think that DP2 antagonists are going to grow hair, let alone maintain hair growth. I don't even see a tiny case report.

So much sadness, because I would absolutely love to have a drug that could maintain hair with a profile like DP2 antagonists. I would even pay huge amounts of money for it monthly.

But I know it's not going to happen.

As, always we will see what the clinical trials will bring .

 

[Folliman]

PGD2 hypothesis isn't based on strong observations, but weak observations.

Finasteride was based on extremely strong observations.

Furthermore PGD2 doesn't induce androgenetic alopecia in mice, lol.

BPH wasn't noted as hair growth side effect, no. There was no case report either.

They were already basically engaging into clinical trials for indication hair loss also.

Based on everything it's pretty deluded to think that DP2 antagonists are going to grow hair, let alone maintain hair growth. I don't even see a tiny case report.

So much sadness, because I would absolutely love to have a drug that could maintain hair with a profile like DP2 antagonists. I would even pay huge amounts of money for it monthly.

But I know it's not going to happen.

As, always we will see what the clinical trials will bring .

PGD2 did inhibit hair growth in mice.

 

[KO1]

PGD2 did inhibit hair growth in mice.

And not just inhibiting hair growth, the follicles were actually miniaturized, what's more, there was sebaceous gland hyperplasia as well. Sound familiar?

I think Seti will probably work, but I don't see why it will outperform finasteride though. But you never know...

 

[Afro_Vacancy]

Seti might find market share if it's weaker than finasteride but has different side effects.

 

[Swoop]

PGD2 did inhibit hair growth in mice.

True. But that's not the same as inducing "androgenetic alopecia" in mice.

I don't believe setipiprant will maintain long term or induce cosmetic regrowth.

Hair follicle cycle alteration is what it probably does and it can help with the "itch".

In fact I predict that alfatradiol even outperforms setipiprant by the numbers, we'll see really.

 

[Folliman]

And not just inhibiting hair growth, the follicles were actually miniaturized, what's more, there was sebaceous gland hyperplasia as well. Sound familiar?

I think Seti will probably work, but I don't see why it will outperform finasteride though. But you never know...

One one hand androgens upregulate DKK1, TGF-b1, etc. On the other hand PGD2 is actively involved in healthy hair follice cycling. Tough to tell which one will win, but I'm optimistic the phase IIa trials will be favorable for seti. We'll see in September...

Worst case scenario, we end up using both finasteride and seti.

True. But that's not the same as inducing "androgenetic alopecia" in mice.

DHT won't induce Androgenetic Alopecia if you're not genetically prone to it. How is PGD2 different?