Diy Topical Finasteride Need An Advice

INT

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I never tried that but I guess it all depends on your goal..

The whole idea of topical finasteride is to avoid, or at least reduce side effects - systemic absorption is lesser with topical. At least my blood exams confirmed some 20-25% reduction in dht compared to 70% in oral.

Since duta has a stronger effect on DHT, if it goes systemic, even in smaller doses, it has the potential to cause more side effects compared to fina.

I'd suggest to try finasteride first and see if it works for you. If you're not worried about side effects just take oral which is less clumsy.

Interesting. So you did tests when you were on oral and when you were on topical? For how long were you on both when you did the tests?
 

Thinning Sucks

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I just add 4-5 finasteride pills cut in half and about 3 dutasteride cut open capsules (drain liquid) to my full bottle minoxidil. It all mixes well. Also was adding 3g RU but seems doing nothing so now adding in some peppermint and lavender rosemary drops (couple squirts in bottle).
 

brzchem

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Interesting. So you did tests when you were on oral and when you were on topical? For how long were you on both when you did the tests?

I took oral for roughly 18 months before side effects were bad (their onset was gradual making hard to notice) and was at that point where I took blood samples.

After a few weeks off of it the side effects subsided / blood levels came back to normal and I decided to try topical on a DIY way. DHT exam was carried after a couple months on it.
 
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smtbbcn

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Question would be if it fully dissolves... Minoxidil and Finasteride both using the same solution might be too much.

Most likely, yes.

Finasteride is freely soluble in ethanol (25mg/ml)
Even 1ml of ethanol will dissolve 25mg finasteride.
 

smtbbcn

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Yes, but Minoxidil dissolves not so easily. It dissolves okayish in Propylene Gylcol, but to dissolve 5% Minoxidil in 60ml of the base-solution, it has to be heated and vigorously shaken (see production of Minoxidil solution). The question that I would have: when adding Finasteride, wouldn't I create some form of metastable super-saturated solution, which - under certain circumstances - might destabilize?

I am no Chemist.... I just ask questions ^^
True, minoxidil need to be heated and stirred until solution is fully clear and yellowish color.

Finasteride instantly dissolved when i added the powder in ethanol, ne need any heat at all.

But crushing pills and then adding all of it with fillers maybe cause some problems. Eg: drop of some minoxidil off solution.

I'd personally make another solution with just finasteride (with ethanol, ppg and water)

I also found this;

20191210_171721.png
 

Kambrira159

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There are several pharmacies in the US and Europe that will do it for you, alternatively morr-f/minoxidilmax are options.
 

brzchem

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I'd personally make two solutions and use them together (that would happen only once a day since finasteride needs to be applied 1x vs 2x for minoxidil).

While it's true that alcoholic solutions easily dissolve finasteride, the vast majority of a pill is made of fillers which may not combine well with minoxidil.

For those on micro-needling: I would wait at least a couple days before applying finasteride after rolling if you want to avoid higher systemic absorption.

ps.: I'm no pharmacist, just an engineer with some knowledge on chemistry.
 

brzchem

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I'm a mining engineer!

It's true that alcohol will dry your scalp, but personally, I use moisturizing shampoo which does the trick for me. I'm also not using Minoxidil which requires a more frequent application and contributes to the problem. However, i'm planning to add it in my regimen (see below).

Currently on 0.5 mg/ml topical fina for 5 days a week (2 day break after rolling) - that means 0.05% if you consider 1 g/ml as 100%
Nizoral every 3 days
Dermarolling once a week
 

brzchem

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I know it's not the right way but I'm only using boiled/filtered water and ethanol.

45 ml composed of 40% ethanol and 60% water with 3 5 mg pills.

Since I apply 30 drops, 1.5ml, that's approximately 0.5 mg daily.

I'm thinking of adding PG though
 
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