finfighter said:
Rabid said:
Since oral users are always prescribed diuretics, that's what I started taking. Even though my pills were really crummy, it still helped with the bloating, which then helped the heart rate.
Yeah, I had Considered doing this as well, if you dont mind me asking which diuretic did you use. Did it eliminate the water retention completely? Did it resolve all of the sides?
Lasix. i can't really say what effect it's having. i am going at this blind, but I would have thought I'd be pissing a lot more than usual. I still think i was slightly less bloated but could be placebo effect. i was taking 20 mg twice a day which is not a huge dose, but the body building sites recommend 10 mg. i've reordered from a different site that is hopefully more legitimate... Since i stopped minoxidil for a few days during my minoxidil cardiac "episode", it could have just resolved on its own without the diuretic.
lasix no doubt should decrease water retention, and thus the cardiovascular issues. The other side effects i'm hoping will be decreased by acetaminophen (more on that below). As to how much lasix is needed to overpower minoxidil bloat i have no idea as i haven't come across anyone discussing this in terms of minoxidil. Not really the safest thing to be messing around with powerful diuretics in the first place but i really don't care anymore at this point, as you can tell by my regimin.
The other drug that needs to be considered is beta blockers to keep heart rate in check. These are also prescribed along with the diuretic for oral minoxidil users as lowered blood pressure causes hear rate to pick up.
finfighter said:
Rabid said:
I recently switched from liquid to foam, and started taking acetaminophen to try and combat the systemic effects. I am using twice the recommended dosage now and am having a little less side effects, so maybe worth a try...
Yeah I never tried the Foam does it seem to have less side effects?
I'm not sure whether it's the switch to foam or acetaminophen or both that's reducing the side effects as i started both exactly the same time. all i know is that i'm using at least twice the recommended dosage of foam, whereas before i was using only the recommended dosage of liquid and yet i seem to have fewer sides so this seems very promising. Even more given the fact that i'm so soon into it (a few days) as the cumulative effects of my liquid minoxidil use alone should take weeks to subside.
finfighter said:
Also why did you think Acetaminophen would improve the cardiac issues, its a -counter analgesic (pain reliever) and antipyretic (fever reducer) I'm not sure why it would help combat these symptoms, do you know otherwise?
I meant to say the acetaminophen was to minimize the systemic effects of minoxidil in general, not for the specific heart problems. Basically, it should prevent the conversion of minoxidil to its much more potent form of minoxidil sulfate, which would probably also be much more potent in causing the sides as well, and since i'm drenching the follicles in so much extra minoxidil there should still be plenty of minoxidil sulfate left confined to the follicles themselves. Speculation or not, I base this on one study:
J Invest Dermatol. 1990 Nov;95(5):553-7.
Minoxidil sulfate is the active metabolite that stimulates hair follicles.
Buhl AE, Waldon DJ, Baker CA, Johnson GA.
http://www.ncbi.nlm.nih.gov/pubmed/2230218
Upjohn Company, Kalamazoo, Michigan 49001.
Abstract
An important step in understanding minoxidil's mechanism of action on hair follicles was to determine the drug's active form. We used organ-cultured vibrissa follicles to test whether it is minoxidil or its sulfated metabolite, minoxidil sulfate, that stimulates hair growth. Follicles from neonatal mice were cultured with or without drugs and effects were assessed by measuring incorporation of radiolabeled cysteine in hair shafts of the treated follicles. Assays of minoxidil sulfotransferase activity indicated that vibrissae follicles metabolize minoxidil to minoxidil sulfate. Dose-response studies showed that minoxidil sulfate is 14 times more potent than minoxidil in stimulating cysteine incorporation in cultured follicles. Three drugs that block production of intrafollicular minoxidil sulfate were tested for their effects on drug-induced hair growth. Diethylcarbamazine proved to be a noncompetitive inhibitor of sulfotransferase and prevented hair growth stimulation by minoxidil but not by minoxidil sulfate. Inhibiting the formation of intracellular PAPS with chlorate also blocked the action of minoxidil but not of minoxidil sulfate. Acetaminophen, a potent sulfate scavenger blocked cysteine incorporation by minoxidi. It also blocked follicular stimulation by minoxidil sulfate apparently by directly removing the sulfate from the drug. Experiments with U-51,607, a potent minoxidil analog that also forms a sulfated metabolite, showed that its activity was inhibited by both chlorate and diethylcarbamazine.