Dupa - The Worst Hairloss Ever ? Need Advice

[thebaldfrench]

Hello everyone,

I know the forum quiet well since I suffer from hairloss for 6 years. At first I tried minoxidil which makes the situation worse with thinner hair and dandruff. But I still use it too afraid to stop.

I added finasteride 2 years later.

There is no improvement my hair are thin; I have a dry scalp (I can see hundred little snow flakes fall when I rub my hair)

Have you ever seen cases like mine ? I know FUE is impossible but maybe I can try something different to reverse it...

 

[BetaBoy]

AFAIK we know very little as to what causes DUPA and that it is quite unlikely that androgens drive the condition, I know this is probably not what you want to hear though.

 

[thebaldfrench]

AFAIK we know very little as to what causes DUPA and that it is quite unlikely that androgens drive the condition, I know this is probably not what you want to hear though.

An answer is an answer ^^

I think the problem is that I don’t know if it’s a skin condition; health related and why I didn’t respond to the big 3

 

[whatintheworld]

It's not good, but still infinitely better than being slick bald, which is what you would be without using any treatments.

Keep using treatments to slow it down, maybe add derma rolling, and keep fighting it.

 

[camille leprevost]

Hello my friend, i am french so i apologise in advance for my english.

I do have the same pattern as you, 28 years old, thinning and overall shedding back, side, and top and my hairline is quite not touched actually. I think it is DUPA and it is similar to female pattern hair loss actually.

Some studies showed that high prolactin level can cause hair on side and back to become sensitive to androgen as well. So might be something to dig in. Also annecdotally, it seems that DUPA sufferer are sensitive to DHT but also to Free testosterone in scalp. Apparently DHT seem to cause localised thinning where testosterone cause diffuse thinning.

If you have been to a dermatologist, i hope she gave you a full bloodwork to do because besides that they are useless

You need to check for :
-nutritionnal defficiency
-metabolism glucidic ((Glucose, insuline sensitivity,)
- full hormonal check : cortisol, LH ,FSH ,Prolactine, E2,17OH progesterone, progesterone, SHBG, testosterone total, free T, androstanediol G6470, delta 4 androstenedione, DHEA-S, DHT ....
- inflamatory syndrom ...

I am going to do a full blood check this friday, so i will send you the result here in 2 weeks if you want. If you have done a full blood work too, it will be great to compare it to check for similitude.

To tell you a bit about myself i started to lose hair all over since 3 years now.
I only started 7 month ago to take 1 mg finasteride daily, but it has thin my hair considerably because of the boost of scalp tesoterone it caused i think. I tried to add different antiandrogen topically such as ru58841 to tackle the rise in T (had to stop due to chest pain , shortness of breath), i used now topical cb0301 30mg/day but it is not enough powerful so it doesn't do sh*t. I am going to try topical bicalutamide now soon as it is a stronger AA and i think we have to fight testoerone as well.
Besides finasteride + cb0301 i don't take any supplement and it didn't stop my shedding at all.

I am curious to know about how much you lose hair per day, what regimen are you on, it seems you use minoxidil, dit it worked on you ? and how you manage to apply it all over your head ?

Also can you share if anything in your regimen has improved your situation so far or make it worse. Would be great to share info

You can send me a message privately as well.

Looking forward helping each other to solve that sh*t.

Best regard

 

[abhi12]

I share some tips to stop hair loss

Diet
Mediterranean diet
Protein
Vitamin A


Supplements
Multivitamin
Vitamin D

Hair care Tips
Regular washing
oil
Gentle styling


Medical treatments
Laser therapy
Platelet-rich plasma


Medications

 

[Here For the Lulz]

Bruh...

My condolences

 

[jan_miezda]

I notice with DUPA. people lose alot of hair in the initial year and then they remain with that hair forever. After you lost your hair rapidly did it stay the same for a long time?

 

[camille leprevost]

Actually it started 3 years ago after a nutritionnal defficiency, i was eating like sh*t, i had tellogen effluvium at the beginning heavy loss in 2 weeks i think but then it never stopped. I am shedding hair all over since then plus miniaturisation (side, back and top).

My shedding and thinning increased with finasteride when i start about 8 month ago but i keep using it just in case. My shedding never stopped and the rate is way faster than classing male pattern baldness. But what it's weird believe me or not my hair texture is changing very fast. For exemple the only things that seem to improve things a bit is eating flaxseed 30mg/day to boost my estrogen and reduce my testosterone/free testosterone and drink 4 cup of spearmint tea a day to reduce free testosterone. When i reduce my testosterone my hair improve in a matter of days, as weird as it is, the thickness increase, they become heavier when i touch them and my libido go down. Everytime my libido go up , my hair texture start to degrade and it is visually perceptible in the mirror. I am a scientific guy so i am not telling you bullshit. I have never been diagnosed officially with DUPA as no hair loss Doctor or dermato know it even exist. But all my symptoms are a clear green light for it, and my symptoms align with every post of dude that claim to have DUPA. Even the fact that finasteride don't do sh*t for me and even make things worst as it boosted my free T an T by about 25%.
I think guys with DUPA are even more sensitive to free testosterone than to DHT as we are diffuse thinner,
In my case there is no part heavily touched on my head , my hairline is quite untouched, but it is gradual loss of density an thining of my hair everywhere. I am heavily conviced that it is still androgen related /free testosterone for the main part, as everytime i shut down my androgen load, shedding reduce and hair improve. I think guys like me need to focus to apply a powerfull antiandrogen topically.

I will send my bloodwork in 2 weeks when i received it.

Happy to hear if anybody have discover some things to help this situation.

Best regards

 

[Will Be an Egg in 5 years]

Actually it started 3 years ago after a nutritionnal defficiency, i was eating like sh*t, i had tellogen effluvium at the beginning heavy loss in 2 weeks i think but then it never stopped. I am shedding hair all over since then plus miniaturisation (side, back and top).

My shedding and thinning increased with finasteride when i start about 8 month ago but i keep using it just in case. My shedding never stopped and the rate is way faster than classing male pattern baldness. But what it's weird believe me or not my hair texture is changing very fast. For exemple the only things that seem to improve things a bit is eating flaxseed 30mg/day to boost my estrogen and reduce my testosterone/free testosterone and drink 4 cup of spearmint tea a day to reduce free testosterone. When i reduce my testosterone my hair improve in a matter of days, as weird as it is, the thickness increase, they become heavier when i touch them and my libido go down. Everytime my libido go up , my hair texture start to degrade and it is visually perceptible in the mirror. I am a scientific guy so i am not telling you bullshit. I have never been diagnosed officially with DUPA as no hair loss Doctor or dermato know it even exist. But all my symptoms are a clear green light for it, and my symptoms align with every post of dude that claim to have DUPA. Even the fact that finasteride don't do sh*t for me and even make things worst as it boosted my free T an T by about 25%.
I think guys with DUPA are even more sensitive to free testosterone than to DHT as we are diffuse thinner,
In my case there is no part heavily touched on my head , my hairline is quite untouched, but it is gradual loss of density an thining of my hair everywhere. I am heavily conviced that it is still androgen related /free testosterone for the main part, as everytime i shut down my androgen load, shedding reduce and hair improve. I think guys like me need to focus to apply a powerfull antiandrogen topically.

I will send my bloodwork in 2 weeks when i received it.

Happy to hear if anybody have discover some things to help this situation.

Best regards

Have you tried estrogen cream?

 

[camille leprevost]

no i did not, didn't explore that route yet. Do you recommend it for DUPA? if yes do you have any estrogen to propose in particular, because i heard that some estrogen are good for hair and other are not.
The only things i tried so far was said in my 2 posts above.

 

[Selb]

no i did not, didn't explore that route yet. Do you recommend it for DUPA? if yes do you have any estrogen to propose in particular, because i heard that some estrogen are good for hair and other are not.
The only things i tried so far was said in my 2 posts above.

Have you gotten a scalp biopsy?

 

[camille leprevost]

no i did not, but what it is used for ?

 

[Selb]

no i did not, but what it is used for ?

It can determine the hair loss you have. Or rule out things like alopecia areata. And if you’re convinced testosterone is your problem, a very simple way to test this would be use a topical AA like RU, CB, or Keto cream

 

[camille leprevost]

I know unfortunately RU58841 gave me chest pain and breathing issue after 1 weeks of usage. I tried even a dosage of 5mg/day but still have breathing sort of issue after some times. So i had to stop very fast before noticing anything. I tried cb0301 for few month now at 30mg /day but as i have to apply it literally everywhere on my scalp it does nothing at this concentration and did not reduce my shedding. And i am conviced that CB0301 is to weak anyway.
The only thing that i can try topically and i think will do something is bicalutamide/enzalutamide/darolutamide.
Enzalutamide cross the blood brain barrier so not good. I have bicalutamide an daro left , but i will use daro as i last resort as i think it is way to powerfull with little safety background. Bicalutamide on the other end seems way more safe.

I just received today bicalutamide (binarex) from inhousepharmacyvu, hoping it is legit, i have a hard time finding a lab in france to test it. so i will try to apply from today 10mg/day in stemoxydine topically, i have seen that is already efficient at that dosage because of it 7 days half life. So going to try that. I am convinced that this time topical bica will work if my pills are legit. If you have any info about how to test the purity of the pill, or what kind of test do i need to ask for in a lab, would be great !!

 

[AndrewBarnes]

I know unfortunately RU58841 gave me chest pain and breathing issue after 1 weeks of usage. I tried even a dosage of 5mg/day but still have breathing sort of issue after some times. So i had to stop very fast before noticing anything. I tried cb0301 for few month now at 30mg /day but as i have to apply it literally everywhere on my scalp it does nothing at this concentration and did not reduce my shedding. And i am conviced that CB0301 is to weak anyway.
The only thing that i can try topically and i think will do something is bicalutamide/enzalutamide/darolutamide.
Enzalutamide cross the blood brain barrier so not good. I have bicalutamide an daro left , but i will use daro as i last resort as i think it is way to powerfull with little safety background. Bicalutamide on the other end seems way more safe.

I just received today bicalutamide (binarex) from inhousepharmacyvu, hoping it is legit, i have a hard time finding a lab in france to test it. so i will try to apply from today 10mg/day in stemoxydine topically, i have seen that is already efficient at that dosage because of it 7 days half life. So going to try that. I am convinced that this time topical bica will work if my pills are legit. If you have any info about how to test the purity of the pill, or what kind of test do i need to ask for in a lab, would be great !!

Everything I ever bought from inhouse has been legit. The thing with bica is that once you start to apply it, you'll notice some sides indicating that it's working. Make sure to have Ralox and an AI hand to combat gyno. Please keep us posted if you ever get it tested or start using it!

 

[Selb]

Everything I ever bought from inhouse has been legit. The thing with bica is that once you start to apply it, you'll notice some sides indicating that it's working. Make sure to have Ralox and an AI hand to combat gyno. Please keep us posted if you ever get it tested or start using it!

I wonder if you can use a topical cream for gyno. Like topical test or dht

 

[AndrewBarnes]

I wonder if you can use a topical cream for gyno. Like topical test or dht

There's a cream on Amazon https://www.amazon.com/Gynexol-Gynecomastia-Body-Sculpting-Cream/dp/B004YZG45M but I doubt that it works

 

[camille leprevost]

A

Everything I ever bought from inhouse has been legit. The thing with bica is that once you start to apply it, you'll notice some sides indicating that it's working. Make sure to have Ralox and an AI hand to combat gyno. Please keep us posted if you ever get it tested or start using it!

yes i started, Applying 10mg bica pill crushed into 5ml stemoxydine all over my head since yesterday. nothing to report yet, no side too. With topical bicalutamide occurrence of gyno is low as i just use 10 mg/day the half life is about 10days so if everything go through my blood it will pic and stay constant at 20 days with a concentration of 100mg in my scalp. Dude who get gyno take an oral pill of 50 mg everyday to block all androgen in their body, that's mean a constant concentration of 500mg after 20 days. If i have feel any bit of nipple pain, i will try DIM as it regulate estrogen, but i don't think it would be an issue.

I plan indeed to get it tested, trying to find a lab right now, but not easy.

By the way DUPA is totaly female pattern baldness in male, a dude just told me that :

"DUPA is female pattern baldness in male. its different gene from same chromosome. its more rare (in male ) because its recessive trait from x chromosome. Regular male pattern baldness is dominant trait from X chromosome
"

 

[camille leprevost]

I got this reply from a labs to get tested my bicalutamide.

"Dear,
Here is our proposal :
1) H-NMR for general structural confirmation
340 Euro, but only structural confirmation (no elucidaton of the structure when it turns out to be something else)
2) Mass spectrometry for molecular mass confirmation
510 Euro
3) NMR purity testing for approximation of purity (optional)
340 Euro"

It seem to me very expensive, is it the correct price ?? is there any labs cheaper or maybe cheaper test to try to be sure it is my coumpound
thanks for your help