dutasteride and 5AR1 brain issue

[Goingat20]

Do you think dutasteride daily could be dangerous in the long run in regards to the brain?

 

[CCS]

we don't know. possibly. reducing 5ar2 80% has bad effects on very few men, so reducing 5ar1 in the brain by 50% maybe would have less effects, but who knows. Even if i knew daily dutasteride regrew more hair than 2-3x per week, I'm still just going to take 3 or at most 4 so I can keep the inhibition of 5ar1 below 20%.

Who knows. Maybe some day they will discover that inhibiting 5ar1 prevents brain cancer. Then I'll take the dutasteride daily or maybe twice a day. I still don't know if adults even need DHT for muscles or anything. Anyone know the answer to that? I guess some guys need it for an errection. If my dutas is real, then I don't seem to need any DHT for an errrection.

 

[Felk]

Apart from reducing your dose to only inhibit a small amount of type 1, another important point I remember is this how dutasteride and finasteride, when they work to inhibit the type 2 enzyme, they work as irreversible inhibitors. However unlike with type 2, dutasteride's inhibition of type 1 isn't irreversible. Bryan posted this a while ago.

 

[Goingat20]

Are you going to give dutasteride a go felk?

 

[iamnaked]

Apart from reducing your dose to only inhibit a small amount of type 1, another important point I remember is this how dutasteride and finasteride, when they work to inhibit the type 2 enzyme, they work as irreversible inhibitors. However unlike with type 2, dutasteride's inhibition of type 1 isn't irreversible. Bryan posted this a while ago.

What are the implications of this in laymans terms if you would be so kind, Sir Felk?

 

[Aplunk1]

I'm so glad Stax isn't around to discuss the 5-AR Type I issue.

 

[Guest]

Even if it does, I really don't care.

By then will be great drugs out to treat brain cancer, but if taking dutasteride 0.5 mg every day lets me keep my hair, then that's pretty sweet.

 

[beaner]

Even if it does, I really don't care.

By then will be great drugs out to treat brain cancer, but if taking dutasteride 0.5 mg every day lets me keep my hair, then that's pretty sweet.

Do you realize how obsessed you've become in less than 2 months on this whole hair loss thing? For someone who is a "NW1 or 1.5 (which isn't even on the Norwood scale) looking to maintain", going on dutasteride after less than 2 months on finasteride, and now saying you really don't care of any adverse effects on your brain as long as you get to keep your hair because you think there will be great drugs to treat brain cancer is truly bizarre in my book. Not trying to offend you in any way Jayman, but you are definitely a bit over-obsessed by a problem that finasteride alone will more than likely solve. I speak from true concern for a fellow CNYer

 

[Guest]

Even if it does, I really don't care.

By then will be great drugs out to treat brain cancer, but if taking dutasteride 0.5 mg every day lets me keep my hair, then that's pretty sweet.

Do you realize how obsessed you've become in less than 2 months on this whole hair loss thing? For someone who is a "NW1 or 1.5 (which isn't even on the Norwood scale) looking to maintain", going on dutasteride after less than 2 months on finasteride, and now saying you really don't care of any adverse effects on your brain as long as you get to keep your hair because you think there will be great drugs to treat brain cancer is truly bizarre in my book. Not trying to offend you in any way Jayman, but you are definitely a bit over-obsessed by a problem that finasteride alone will more than likely solve. I speak from true concern for a fellow CNYer

Thanks Beaner.

I totally agree that I have been completely obsessed with it and I don't take offense at your statement because it is the truth. I was a bit rash with my remarks and I think I would care if I got brain cancer, but to be honest I don't think that finasteride will solve the problem for me. I have a bad genetic history with regard to hair loss, and even if finasteride works now it will probably just maintain my hair, and I would like to regrow some in front. dutasteride is the drug to do that and I heard that it worked for Aplunk. My frontal hair loss is fairly recent so I am going to stay on that indefinitely and continue taking the finasteride 3x a week in case the dutasteride is fake. I know it probably isn't and it's probably just mimicing the work, but it makes me feel better, you know?

dutasteride is prescribed for men with enlarged prostates and it is an FDA approved drug for that so I do feel comfortable taking it and am not worried about inhibiting the type 1 5AR.

 

[CCS]

drugs are FDA approved if their benifit profile outweighs their risk profile. Just because a drug is FDA approved does not mean you should take it, even if you are healthy. I think you should take dutasteride, but not for that reason.


5ar1 being reversible does not seem relevant. Either way, 50% of DHT is inhibited, which gives the same effect.

 

[IBM]

.

 

[CCS]

more research is needed and oral dutasteride may prevent prostate cancer and denser body hair.

i wish I knew if DHT or testosterone plays a bigger role in androgenic skin properties such as bigger pores.

 

[Felk]

Apart from reducing your dose to only inhibit a small amount of type 1, another important point I remember is this how dutasteride and finasteride, when they work to inhibit the type 2 enzyme, they work as irreversible inhibitors. However unlike with type 2, dutasteride's inhibition of type 1 isn't irreversible. Bryan posted this a while ago.

What are the implications of this in laymans terms if you would be so kind, Sir Felk?

I don't really know what the implications are, but I think Bryan explains it better here (at least in terms of inhibitting type 2), scroll down and see his post using the switching off the tap analogy (finasteride blocking DHT)

http://www.hairlosstalk.com/discussions ... s&start=20

 

[Felk]

This might also be interesting (although Bryan says here that type 2 does "grow back," only slower than type 1, so maybe "irreversible" isn't the right word)

So, after taking oral finasteride, on a daily basis, the 5AR enzyme steadily grows back?

Yes. There's constantly a turnover of enzyme, whether or not you take inhibitors like finasteride/dutasteride.

I just checked the Gisleskog study like I promised I would do a day or two ago: they say that the turnover "half-life" of the type 2 enzyme is 80 hours, and 45 hours for the type 1 enzyme. In other words, the type 1 enzyme grows back FASTER than type 2, which is one of the reasons that dutasteride is less effective against type 1 than type 2.

So it makes sense when you think about it: you take a Proscar tablet one day, and it knocks out about 90% of the type 2 enzyme after 24 hours. And by 3 1/3 days after THAT, only about half of the missing type 2 activity has recovered. It's not surprising that it takes a few more days for DHT levels to get back up to where they were at the beginning.

Bryan

 

[balu123]

I take dutas 0,5mg daily and yes it affects my erection.
I need more time to come and the orgasm is more intensiv...

so, reducing 5ar1 in my brain seems not to be so bad.

bye
balu

 

[balu123]

btw:
I don't know if I should switch to 4 pills a week...
(mondy, wednesday, friday, sunday)
but if, when should I start?

I'm taking one everyday since 14 days.
Because I read something about a loading phase?

bye
felix

 

[Felk]

Last longer, plus more intensive orgasm?

Das scheint nicht so schlect zu sein...

 

[MPBWarrior]

btw:
I don't know if I should switch to 4 pills a week...
(mondy, wednesday, friday, sunday)
but if, when should I start?

I'm taking one everyday since 14 days.
Because I read something about a loading phase?

bye
felix

Yes, i suggest u cut that dosage down to about 3 times a week of 0.5mg of dutasteride instead of every day. especially since no one knows the long term effects of dutasteride (even on the brain!).

 

[iamnaked]

btw:
I don't know if I should switch to 4 pills a week...
(mondy, wednesday, friday, sunday)
but if, when should I start?

I'm taking one everyday since 14 days.
Because I read something about a loading phase?

bye
felix

Yes, i suggest u cut that dosage down to about 3 times a week of 0.5mg of dutasteride instead of every day. especially since no one knows the long term effects of dutasteride (even on the brain!).

Well... DHT deficiency in males has been studied (In the Dominican republic especially), to find that it has no noticeable negatives on men apart from a failure to go through puberty. To cast doubt on Dutasteride's saftey would be to posit some kind of contraindication with other medicines, or how it affects other parts of the body, both of which remain unproven, despite it having been around for absolutely years.

 

[powersam]

i thought those dominican kiddies only had no type2 5 alpha reductase. they still had type 1 as far as i know.

that aside i think if dutasteride had any serious unlisted side effects they would have been reported at some point in the 14(?) odd years its been in use.