dutasteride and 5AR1 brain issue

Bryan

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Felk said:
This might also be interesting (although Bryan says here that type 2 does "grow back," only slower than type 1, so maybe "irreversible" isn't the right word)

Finasteride and dutasteride are considered to be "irreversible" inhibitors of the type 2 enzyme (but not of the type 1 enzyme, which is just a competitive type of inhibition) because once either one of them binds to a molecule of that enzyme, that specific molecule is essentially destroyed. It won't produce DHT again. Of course, it will eventually be replaced by newly synthesized enzyme molecules.

Bryan
 

Bryan

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powersam said:
i thought those dominican kiddies only had no type2 5 alpha reductase. they still had type 1 as far as i know.

That's correct. They have normal levels of the type 1 enzyme.

Bryan
 
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