Exploring The Hormonal Route. Hair=life.

[itchymadscalp]

castration will destroy all the androgen in your system 24/7 with no chance of androgens rebound or resistance to build up in the receptors ,it is the most potent method of androgen deprivation,it is only used for stage 4 patients who have severe cases of prostate cancer or cancerous tumor and are not responding to any anti-androgens and gave up all hope on AAs, some people do not react to anti-androgen no matter what and how strong the dose is, even if the blood serum of testosterone is within a castrate level, in some cases anti-androgens fail to eliminate free testosterone which is bioavailable version of testosterone and it is deadly but not shown on blood tests.

1. most AAs have a half-life and if the medication is not taken properly or if it is discontinued without monitoring its effect, it can mess up with the receptors and overactivate them, this happened to @itchymadscalp , he was on a strong AA and his hair was perfect, but for some reason he discontinued the AA and jumped to dutasteride, you can't go from a strong regimen to a weaker one, your receptors will catch up and you will have a problem.
2.anti androgens may cause an adverse reaction to the receptors and induce androgen receptor upregulation, just like @itchymadscalp 's case, where the receptors are ultra sensitive to FREE testosterone, not only total testosterone
3. the body will find a way to resist the drug eventually, and some resistance may build up to the drug if it is misused, or used for a very long, or are taken on and off, which is very dangerous
4. anti-androgen can cause an increased level of prolactin, and prolactin is shown to increase androgenic activity in the receptors, look it up
5. AAs are drugs at the end, and drugs are man-made, not really perfect for everyone's physiology some people are exceptions, but orchiectomy, on the other hand, will eliminate the natural factories of androgens and that will work 100%

note that ani androgens work very well in 98% of people, and any weak responders or people with overactive receptors are outliers,and surgical castration may help them as their last hope,men with severe cases of prostate cancer who are on AA, and not responding like their peers, will be offered to go under this procedure,and they have to accept the loss of their balls because it is life or death for them, but for me baldness is death, so I chose life and boobs.

there is a slim chance that @itchymadscalp will be cured with surgical castration, but it is worth it? he decides not us

I really don't think physical castration will be a game changer for me. I'm already on Lupron. it's pretty effective. But because of long term use of Dutasteride something is wrong. If I had knew ... Lupron was working, I wanted to get my libido back ... for my BF. And now I'm miserable because of that mistake.
Castration + estradiol is safer than Dutasteride, I cannot back up my claims.

 

[itchymadscalp]

With the estradiol, make sure it’s as hemihydrate since that one can be used buccally. It apparently bypasses the liver and goes directly in the blood stream when used that way (through the buccal mucosa). When starting spironolactone, I would recommend that you start with 50MG/day for a few days, then increasing the dose to 100MG for a few days, then using 200MG/day.

You should try asking your doctor for bicalutamide instead of spironolactone eventually, since it’s safer for long-term use.

You can take estradiol valerate sublingually. I tried, same levels with hemihydrate actually.

 

[Sonolmn98]

I really don't think physical castration will be a game changer for me. I'm already on Lupron. it's pretty effective. But because of long term use of Dutasteride, something is wrong. If I had knew ... Lupron was working, I wanted to get my libido back ... for my BF. And now I'm miserable because of that mistake.
Castration + estradiol is safer than Dutasteride, I cannot back up my claims.

so you dropped the lupron and jumped to dutasteride to get the libido back? this is really bad, no wonder why your androgens receptors are overactive, sex is game over on E+ antiandrogens, you should have added progesterone, as it helps for the libido, but dropping the AA all the sudden will cause trouble, anyone is going on this route must be prepared to give up sex, because even if your dick works, after all this, your libido and sense of pleasure will diminish,you choose between sex and hair, and not many gonna give up sex for it, the cost is very big, but for me as an asexual person, this is a blessing because I dnt have to deal with sexual urges and spontaneous thoughts of lust

 

[Ikarus]

so you dropped the lupron and jumped to dutasteride to get the libido back? this is really bad, no wonder why your androgens receptors are overactive, sex is game over on E+ antiandrogens, you should have added progesterone, as it helps for the libido, but dropping the AA all the sudden will cause trouble, anyone is going on this route must be prepared to give up sex, because even if your dick works, after all this, your libido and sense of pleasure will diminish,you choose between sex and hair, and not many gonna give up sex for it, the cost is very big, but for me as an asexual person, this is a blessing because I dnt have to deal with sexual urges and spontaneous thoughts of lust

I agree, although I think it’s easier to not care much about libido if you naturally have a lower libido. Personally, I was put off the idea of sex long before starting treatments. I guess it would be a similar situation for others, especially those who don’t like being touched inappropriately.

 

[Ikarus]

I can’t wait to drop the spironolactone... No more constipation!

 

[itchymadscalp]

so you dropped the lupron and jumped to dutasteride to get the libido back? this is really bad, no wonder why your androgens receptors are overactive, sex is game over on E+ antiandrogens, you should have added progesterone, as it helps for the libido, but dropping the AA all the sudden will cause trouble, anyone is going on this route must be prepared to give up sex, because even if your dick works, after all this, your libido and sense of pleasure will diminish,you choose between sex and hair, and not many gonna give up sex for it, the cost is very big, but for me as an asexual person, this is a blessing because I dnt have to deal with sexual urges and spontaneous thoughts of lust

Yeah I was first on Cypro for a year, then I could convince my Doctor to give me Lupron, I used it for a year. But no libido, and I met my BF ... he was not ok with castration, so I jumped on Dutasteride, hoping to get my libido back and keep my hair. I kept my hair for a while, but still no sexdrive at all ...
I was not really aware of what I could do for my libido except dropping Lupron.

 

[itchymadscalp]

Leaving a message here just because I want to have 666 messages <3

 

[Ikarus]

Yeah I was first on Cypro for a year, then I could convince my Doctor to give me Lupron, I used it for a year. But no libido, and I met my BF ... he was not ok with castration, so I jumped on Dutasteride, hoping to get my libido back and keep my hair. I kept my hair for a while, but still no sexdrive at all ...
I was not really aware of what I could do for my libido except dropping Lupron.

That’s why I wouldn’t dare get a boyfriend nowadays, unless they’re asexual or something... I wouldn’t want them to be annoyed because I don’t want to do ‘it’. Men are just too sexually active

 

[Sonolmn98]

Yeah I was first on Cypro for a year, then I could convince my Doctor to give me Lupron, I used it for a year. But no libido, and I met my BF ... he was not ok with castration, so I jumped on Dutasteride, hoping to get my libido back and keep my hair. I kept my hair for a while, but still no sexdrive at all ...
I was not really aware of what I could do for my libido except dropping Lupron.

past is the past, now you have to move on, and accept what happened, surgical castration might help but not guaranteed in your case, I really want to help you to find a working protocol but it is hard and complicated, worse case scenario, you can get a hair system or a transplant, how about taking testosterone for a while to calm down the receptors and then go on lupron cold turkey, I am sure there is a way to undo the damage but I am, not a doctor and not really smart in this field, good luck brother, I wish you the best, stick around and keep experimenting, we will find this battle to the last breath, keep fighting! and f*** baldness

 

[Sonolmn98]

That’s why I wouldn’t dare get a boyfriend nowadays, unless they’re asexual or something... I wouldn’t want them to be annoyed because I don’t want to do ‘it’. Men are just too sexually active

I agree, men are disgustingly horny and lustful, after going this route I became very hostile to men, now I find myself more in tune with women or asexual people, they feel more and have a wider spectrum of feelings, unlike men who are just running after sex to satisfy their big ego, that's why I don't consider myself gay

 

[itchymadscalp]

past is the past, now you have to move on, and accept what happened, surgical castration might help but not guaranteed in your case, I really want to help you to find a working protocol but it is hard and complicated, worse case scenario, you can get a hair system or a transplant, how about taking testosterone for a while to calm down the receptors and then go on lupron cold turkey, I am sure there is a way to undo the damage but I am, not a doctor and not really smart in this field, good luck brother, I wish you the best, stick around and keep experimenting, we will find this battle to the last breath, keep fighting! and f*** baldness

I will try to keep my regimen until january 2022. If its definitively not working .... I will give up and maybe get an hair system. I cannot take testosterone, I'm afraid of testosterone, I mean it. The last time I let testosterone come back ... it was a nightmare, the pain was even higher. And I'm afraid to be even more manly. I know I should give up but I cannot accept that there is no hope. I'm trying very high dose estradiol. But I cannot try high dose testosterone (I could take Tamoxifen, my testosterone level will be really high ... but no it's to scary).
Bye my 666th message :/

 

[itchymadscalp]

That’s why I wouldn’t dare get a boyfriend nowadays, unless they’re asexual or something... I wouldn’t want them to be annoyed because I don’t want to do ‘it’. Men are just too sexually active

My BF is not a pervert ... but yeah it's frustrating because he can feel some pleasure, and I don't. Because of Dutasteride I think (post finasteride syndrome). I'm still lucky to have him, because he accepts me, even if I'm a freak.
You could find someone special too.

 

[Sonolmn98]

My BF is not a pervert ... but yeah it's frustrating because he can feel some pleasure, and I don't. Because of Dutasteride I think (post finasteride syndrome). I'm still lucky to have him, because he accepts me, even if I'm a freak.
You could find someone special too.

yeah strangely enough, with AA and estrogen, your penis works perfectly during sex but the sense of pleasure and the power of orgasming and the sex drive are destroyed for some odd reason, even on a high estrogen dose it is the same case, i don't get spontaneous erections anymore,but I can get hard if I want to but no feelings what so ever

 

[itchymadscalp]

yeah strangely enough, with AA and estrogen, your penis works perfectly during sex but the sense of pleasure and the power of orgasming and the sex drive are destroyed for some odd reason, even on a high estrogen dose it is the same case, i don't get spontaneous erections anymore,but I can get hard if I want to but no feelings what so ever

For my part it's not because of estradiol, but because I used Dutasteride/Finasteride (PFS). But for you ... maybe it's because of the surgery. Or maybe because your body is not yet used to estrogen. You could try with a vibrator .. maybe you need something new to get some pleasure.
I'm sure you will have your sex-drive back in a few momths, maybe in a different way.

 

[bridgeburn]

That’s why I wouldn’t dare get a boyfriend nowadays, unless they’re asexual or something... I wouldn’t want them to be annoyed because I don’t want to do ‘it’. Men are just too sexually active

you and Sonolmn might make a great couple

 

[bridgeburn]

yeah strangely enough, with AA and estrogen, your penis works perfectly during sex but the sense of pleasure and the power of orgasming and the sex drive are destroyed for some odd reason,

In my case the sense of pleasure and orgasm is stronger than it ever was

 

[bridgeburn]

maybe you need something new to get some pleasure.
I'm sure you will have your sex-drive back in a few momths, maybe in a different way.

probably the first step is that he has to actually want to have a sex drive

 

[Sonolmn98]

In my case the sense of pleasure and orgasm is stronger than it ever was

you are a god then, maybe because as your hair improves, your depression goes away, therefore, you are more likely to enjoy life and live to your potential, the mind is very powerful, you have regrown hair from bare baldness, then I won't be surprised to know that, it all about bio-hacking and manipulating the fuked up nature rules, there are tons of things that science and humans failed to know until this day

 

[Sonolmn98]

probably the first step is that he has to actually want to have a sex drive

I might add progesterone if I want it back but otherwise, it is not a big deal,I am more excited about the regrowth even on progesterone

 

[Ikarus]

I cut my sideburns too short, so people can be distracted by that instead of my baldness!!