Exploring The Hormonal Route. Hair=life.

[DogoDiLaurentiis]

Is it possible that taking a vitamin K2 supplyment while applying topical estrogen b17 would negate feminising effects? Or would it just stop receptor binding in the follicle too?

Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism - PubMed

Vitamin K is a cofactor for gamma-glutamyl carboxylase, an enzyme that is important for blood coagulation. Recent studies have shown that vitamin K has other roles, in addition to post-transcriptional modification, such as bone metabolism and antitumoral actions; these findings have indicated...

pubmed.ncbi.nlm.nih.gov

Be extremely f*****g careful with vit k2 and estrogen, the combined blood clotting could f*** you up.

And no, the simple answer is I've had virtually no extreme feminizing effects and I'm rocking straight 17b estradiol gel applied to my scalp.

Not even f*****g gyno, of all things my facial hair growth slowed down just a little but not even compared to what it was back when I was in my 30s when I could get away with shaving once every couple of days.

So people freaking out about it, no you have nothing to worry unless your liver does not metabolize estrogen quickly, and then it will build up fast, and if that's the case that means you already probably have higher levels of circulating estrogen as it is, meaning more estrogen is probably not going to help much.

 

[Almas]

What effect will one press of 0.75mg E have? Will this give any effect, or is the minimum dose 1.5mg E, i.e. 2 pump presses? In general, Bicalutamide at a dose of 100mg completely blocks androgens, so I don't think there is a need for estradiol. However, this can speed up regrowth. And then support him on Bicalutamide

 

[Pls_NW-1]

What effect will one press of 0.75mg E have? Will this give any effect, or is the minimum dose 1.5mg E, i.e. 2 pump presses? In general, Bicalutamide at a dose of 100mg completely blocks androgens, so I don't think there is a need for estradiol. However, this can speed up regrowth. And then support him on Bicalutamide

Almas, Bicalutamide does not raise estrogens to high female ranges, so the hair can regrow. That´s why Bicalutamide monotherapy is not used by MtF, only for Cancer patients.


It will surely stop male pattern baldness, as long as it is taken, but I wouldn´t expect significant cosemtical regrowth on Bicalutamide + Finasteride/Dutasteride. We still need growth stimulants, and I think estrogen would be the best because then we can stop it and maintain with the AAs, but with Minoxidil, you are tied to it for ever, dropping topicals to your scalp, ew.

 

[Pls_NW-1]

What effect will one press of 0.75mg E have? Will this give any effect, or is the minimum dose 1.5mg E, i.e. 2 pump presses? In general, Bicalutamide at a dose of 100mg completely blocks androgens, so I don't think there is a need for estradiol. However, this can speed up regrowth. And then support him on Bicalutamide

Almas, I think you will be great on 100mg Bicalutamide. Don´t play with hormones much, Bica is already playing with fire.

 

[Almas]

Almas, I think you will be great on 100mg Bicalutamide. Don´t play with hormones much, Bica is already playing with fire.

I just think about plan C

 

[Pls_NW-1]

I just think about plan C

Wait. What are your other plans!? What are your plans in general!? Haha

 

[Almas]

Wait. What are your other plans!? What are your plans in general!? Haha

50mg Bica, 100mg Bica, 75mg Bica + E, Suicide

 

[Pls_NW-1]

50mg Bica, 100mg Bica, 75mg Bica + E, Suicide

I feel you. Might be horrible if even 100mg bica wont halt it.

 

[franzliszt]

I feel you. Might be horrible if even 100mg bica wont halt it.

I was on 100mg and patches last year for a couple of months which didn't do much. Only after I added finasteride did things start to work.

 

[Pls_NW-1]

I was on 100mg and patches last year for a couple of months which didn't do much. Only after I added finasteride did things start to work.

you need to combine 5ARi + Bica. Thats a rule lol

 

[Almas]

I was on 100mg and patches last year for a couple of months which didn't do much. Only after I added finasteride did things start to work.

Have you tried 100mg + finasteride or 50mg + finasteride? Without E
100mg should work even without finasteride, they block all androgens

 

[franzliszt]

Have you tried 100mg + finasteride or 50mg + finasteride? Without E
100mg should work even without finasteride, they block all androgens

In theory it should work, but it just wasn't enough. within 3 weeks of starting finasteride my scalp itch went away, and I started feminizing.

 

[tato123]

Have you tried 100mg + finasteride or 50mg + finasteride? Without E
100mg should work even without finasteride, they block all androgens

Correct me if I'm wrong, but I think DHT has more affinity for the receptor than bicalutamide, so I think a 5ar blocker is strictly necessary.

 

[Pls_NW-1]

In theory it should work, but it just wasn't enough. within 3 weeks of starting finasteride my scalp itch went away, and I started feminizing.

What do you consider as feminization? What did you experience? Crazy, indeed. 150mg schould stop androgenic action (undetectable PSA) dead in tracks lol

 

[Pls_NW-1]

Correct me if I'm wrong, but I think DHT has more affinity for the receptor than bicalutamide, so I think a 5ar blocker is strictly necessary.

It is! But at 150mg, Bica is OP to all androgens for the receptor because there are eg.: 1000 bicas vs. 1 DHT lol. Concentration is a key factor, it is proven that androgen concentration is much higher in balding scalp than in non-balding scalp, I really wonder why!?

 

[Almas]

In theory it should work, but it just wasn't enough. within 3 weeks of starting finasteride my scalp itch went away, and I started feminizing.

Have you tried 50 or 75mg with Finasteride? Smaller doses of Bica help, or 100mg is the minimum?

Correct me if I'm wrong, but I think DHT has more affinity for the receptor than bicalutamide, so I think a 5ar blocker is strictly necessary.

Even lowering PSA by 97% doesn't stop this sh*t ...

 

[tato123]

It is! But at 150mg, Bica is OP to all androgens for the receptor because there are eg.: 1000 bicas vs. 1 DHT lol. Concentration is a key factor, it is proven that androgen concentration is much higher in balding scalp than in non-balding scalp, I really wonder why!?

Nice explanation, it makes sense, but I would not risk bicalutamida without 5ar blocker in any dosage.

 

[Pls_NW-1]

Nice explanation, it makes sense, but I would not risk bicalutamida without 5ar blocker in any dosage.

Neither! 5ARi is totally needed, especially for the fact that you then can use a lower bica dosage; 100mg.

 

[Pls_NW-1]

Have you tried 50 or 75mg with Finasteride? Smaller doses of Bica help, or 100mg is the minimum?

Even lowering PSA by 97% doesn't stop this sh*t ...

Then, I wonder if it is even androgen driven...

 

[franzliszt]

What do you consider as feminization? What did you experience? Crazy, indeed. 150mg schould stop androgenic action (undetectable PSA) dead in tracks

Face softening, lowered sex drive etc. I think there's some unknown action to finasteride, given the brain fog/depression it gives me.