Exploring The Hormonal Route. Hair=life.

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Almas

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In addition to the fact that hair regrowth on HRT is faster than baldness, I found that FTMs usually go bald after a year on testosterone.
These facts give hope that the idea of estrogen cycles is feasible.
But as always, only theory. In theory, Bicalutamide is the perfect medicine, but we know how Jacob Williams' story and mine ended
 
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Norwoody

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As I've mentioned before, testosterone is still highly androgenic, though of course DHT is the androgenic kingpin. Over the years, anabolic steroids were developed to have less androgenic components and more anabolic components because the very first steroids were causing terrible side effects in athletes - prostates were blowing up like balloons after a few short years on the drugs, women who took them were becoming infertile, etc. The big breakthroughs were with dianabol and anavar, designed to be much less androgenic than testosterone. So Almas' point about testosterone is not to be taken lightly. Guys who are on TRT are definitely at risk of losing a lot of hair. Derek the MPMD guy lost a lot of hair while he was just doing testosterone and dutasteride. He improved his hair after backing off the testosterone, and he also takes finasteride now instead of dutasteride. Additionally, there is an anecdote on the forums of a guy who improved his hair while taking anavar. Bottom line is that testosterone is still plenty androgenic, especially if you have sensitive follicles. And any FtMs, or guys who take steroids, would be better off doing low-dose anabolic steroids and avoiding testosterone altogether if possible.
 
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Almas

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I was thinking about using HRT and anabolic steroids in order to be able to maintain my body in a masculine state. For example, nandrolone has a much stronger effect on muscles than testosterone, while it does not affect skin and hair. Sounds perfect, doesn't it? Therefore, women who are involved in bodybuilding build muscle, but do not go bald. There are also various SARMs that bodybuilders use. I am trying to get my head around this topic
I am trying to understand how all of these drugs affect estradiol levels.
But I think they have serious side effects, and it's best not to mess with it. Moreover, I like to be thin
 
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Almas

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Descending Dog said:
Has anyone lowered their scalp DHT above 90% is that possible?
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This is possible with HRT. Dutasteride does not reduce DHT in the scalp sufficiently. Bicalutamide, in theory, should prevent DHT from binding to receptors at an adequate dosage, but it did not help me
 
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Almas

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Bicalutamide is effective in only 53% of cases of female pattern baldness. Unsurprisingly, at least half of those who tried it didn't help.
HRT may not help either, because even on HRT there will be low levels of T and DHT, and if you did not respond to Bicalutamide, you will simply continue to go bald even at the female hormonal level. Nothing can be done about it. If I have not answered Bicalutamide and am balding on the back of my head, it is quite possible that HRT will not give me anything We cannot completely get rid of androgens, and blocking the receptors does not always work. Thus, we do not have a medicine that is guaranteed to help
Spironolactone and CPA are even less effective than Bicalutamide, so the percentages are even lower in their case. Add to this the fact that Androgenetic Alopecia has more than just androgenic mechanisms. In general, we will never defeat this disease
 
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keepcoolmybabies

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Almas said:

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Bicalutamide is effective in only 53% of cases of female pattern baldness. Unsurprisingly, at least half of those who tried it didn't help.
HRT may not help either, because even on HRT there will be low levels of T and DHT, and if you did not respond to Bicalutamide, you will simply continue to go bald even at the female hormonal level. Nothing can be done about it. If I have not answered Bicalutamide and am balding on the back of my head, it is quite possible that HRT will not give me anything We cannot completely get rid of androgens, and blocking the receptors does not always work. Thus, we do not have a medicine that is guaranteed to help
Spironolactone and CPA are even less effective than Bicalutamide, so the percentages are even lower in their case. Add to this the fact that Androgenetic Alopecia has more than just androgenic mechanisms. In general, we will never defeat this disease
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I think those that are unresponsive to extensive androgenic alopecia treatments likely have a different mechanism of hairloss than androgens.
 
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Almas

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keepcoolmybabies said:
I think those that are unresponsive to extensive androgenic alopecia treatments likely have a different mechanism of hairloss than androgens.
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Androgenetic Alopecia has different mechanisms, but it would be better if they were only androgens: the rest of the mechanisms are unknown to us. Apparently if the genetics are too bad and you are programmed to go bald no matter what, this is a sentence
 
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Descending Dog said:
@Almas what would happen if somebody injects strogen in their scalp and then takes aromatasa inhibitor. Like what if the majority of strogen your body is getting is through those scalp injections? Is it possible to avoid unwanted side effects this way?

I need to research and make a thread to ask these questions if there's anybody who bothers to say anything it's gonna be appreciated.
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Estrogen does not have a concentrated topical effect. You can just as well use HRT and Tamoxifen, which will not relieve you of feminization, but can harm your hair.
We have no way out except HRT, although even this does not help everyone
 
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ChemHead

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Descending Dog said:
@ChemHead
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The reason why this doesn't work is because you have to have the substrate (aromatizable androgens) and the machinery (aromatase) to produce the estrogens right where they're needed. This is the only way to get concentrations that are high enough without having to inject a pretty serious amount of estrogens. The ability to produce locally on demand means that you can have high concentrations of steroids without affecting the serum concentrations of those steroids.
 
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Descending Dog said:
In your opinion, how can you upregulate this process locally? No matter how crazy or dangerous it could be.
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I've personally found that the healthier you are, the higher both 5AR expression and aromatase are.

But, in terms of drugs or chemicals, you can find something to upregulate aromatase expression and maybe try to use it topically. Prostaglandin E2, dexamethasone, and ricinoleic acid all upregulate aromatase expression. Or you could bypass all that and try an ER agonist that is highly selective for ER beta and won't cause HPTA dysregulation. 8b-vinylestradiol and WAY-200070 both fit this specification, in theory due to their exceedingly high selectivity for ERb over ERa.
 
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ChemHead

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Descending Dog said:
Is there a reason why nobody has tried this?

Thanks for your time and answers you're one of the users that I always follow.
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I'm going to be trying it soon. I'm working on getting WAY-200070 sourced. WAY is relatively new. I'm not sure how long 8b-vinylestradiol has been around. Neither of these are necessary easy to get ahold of, though. They're not prescription drugs... They're compounds under research and development. So, you have to find a lab to synthesize them.
 
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Norwoody

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Descending Dog said:
Is there a reason why nobody has tried this?

Thanks for your time and answers you're one of the users that I always follow.
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I remember on a thread a while back we discussed this somewhere. I forget the name, but there is an experimental synthetic estrogen modified to have a way higher affinity for ER-b, and someone managed to find a source, but it was like ten thousand dollars for a gram or something lol.
 
Rysteve93

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Months since I’ve been around.

5mg oral minoxidil (15 months 5mg-40mg)
50mg bic (3/4 months)
0.5 dust (3 yrs)
estro gel eod 1.5mg
 

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A

Almas

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Rysteve93 said:
Months since I’ve been around.

5mg oral minoxidil (15 months 5mg-40mg)
50mg bic (3/4 months)
0.5 dust (3 yrs)
estro gel eod 1.5mg
Click to expand...
How the results have changed since you added Bicalutamide (100mg per day, as I understand it). What do you think plays a decisive role in your regime?
I am skeptical about estrogel at such low dosages. Are you applying it to your head or trying to lower your T level? I thought a lot about microdosing estradiol and came to the conclusion that it is useless, because even HRT gives poor results.
 
Rysteve93

Rysteve93

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Almas said:
How the results have changed since you added Bicalutamide (100mg per day, as I understand it). What do you think plays a decisive role in your regime?
I am skeptical about estrogel at such low dosages. Are you applying it to your head or trying to lower your T level? I thought a lot about microdosing estradiol and came to the conclusion that it is useless, because even HRT gives poor results.
Click to expand...
50mg per day as I said above. Mate what plays a diverse role is not complaining about it and f*****g around with dosages all the time. Go outside, enjoy the sun, socialise, laugh, not constantly putting yourself down over hair, life’s too short.

anyway cya’s in a few months lol.
 
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