Exploring The Hormonal Route. Hair=life.

pentobean

pentobean

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Adri23 said:
I'm getting so much brain fog lately btw. Im not sure if it is the bica 25 mg EOD with androgens already low or lowering my estradiol. Will try to lower bica to 12.5 mg daily to see if it helps, but I am almost certainly sure it is the bica since my SHBG is 95.7 nmol/L for no reason at all. SHBG should be way lower since my e2 is so 'low' for my body that it has increased my LH (which Idc since I have an orchi) but I think it can't decrease simply because I have not enough androgens to make it lower. There are ppl literally using topical T to reduce shbg so prob my best move is reduce the bicalutamide intake.
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Is there anyway I can contact you? I’m considering doing a diy orchiectomy. Please, tell me your results. I don’t have any option to do it
 
J

Jonah

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corn_scoops said:
BC gt20029 destroys the androgen receptor. In Reflex hyper androgenicity the receptors get up regulated . Since GT 20029 destroys the receptor , it’s all good
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Interesting. I wonder of anti androgens in general would help for reflex hyperandrogenicity?
 
Mr. Slap Head

Mr. Slap Head

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Jonah said:
So you’re saying it wont help it, it will just make it worse?
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There's nuance to it...

Sometimes AAs can be so powerful that it can overwhelm the system to where there are no noticeable symptoms of RH, and hair improves.

Regardless, no matter who you are, AAs will cause an INTENSE upregulation at the androgen receptor. The question is, is the reduction of the number of circulating androgens enough to negate the effects of said upregulatory effects? For some, the answer may be yes, however, for others, it may be no. That is why some experience more hair loss on AAs. Individual response will vary, not only based on the user's genetics, but on the type and amount of AA used! (There are many!)

The thing about estrogen is that it has some of the effects of a standard AA (reducing androgen ligands), except that instead of upregulating the receptor, it DOWNREGULATES the AR. That is why it can be extremely effective for some. By extension, and interestingly enough, increasing androgenic load actually downregulates the receptor as well (this is, in part, the reason why PFS exists).
 
J

Jonah

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Mr. Slap Head said:
There's nuance to it...

Sometimes AAs can be so powerful that it can overwhelm the system to where there are no noticeable symptoms of RH, and hair improves.

Regardless, no matter who you are, AAs will cause an INTENSE upregulation at the androgen receptor. The question is, is the reduction of the number of circulating androgens enough to negate the effects of said upregulatory effects? For some, the answer may be yes, however, for others, it may be no. That is why some experience more hair loss on AAs. Individual response will vary, not only based on the user's genetics, but on the type and amount of AA used! (There are many!)

The thing about estrogen is that it has some of the effects of a standard AA (reducing androgen ligands), except that instead of upregulating the receptor, it DOWNREGULATES the AR. That is why it can be extremely effective for some. By extension, and interestingly enough, increasing androgenic load actually downregulates the receptor as well (this is, in part, the reason why PFS exists).
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This is fascinating.

Can you explain your 2 possible methods regarding downregulation a bit more?

Whats the idea in why increasing dht would potentially downregulate?

And why is it that estrogen can down regulate?
 
E

exwhyyou

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Adri23 said:
Idk I asked same question long ago, a person told me he killed himself because he reggreted the balls removal but I am not sure how true that is.
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i just cant forget people being surprised that he was still on oral minoxidil after the orchi as if hair was going to magically regenerate immediately as the balls disconnected from his body
 
H

Henkied

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exwhyyou said:
i just cant forget people being surprised that he was still on oral minoxidil after the orchi as if hair was going to magically regenerate immediately as the balls disconnected from his body
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A growth stimulant is very important, even average women use minoxidil nowadays without having any underlying hair issues
 
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