f*** YOU ALL - DR TAKASHI TSUJI UPDATE

[H]

“Hello again, and thank you once again for your sincere interest in this area. Although technically, anything is possible, Kyocera has no further plans to announce on this topic at the present time.”

Ouch...I have a feeling that "present time" is gonna extend for awhile...

 

[jan_miezda]

Now that tsuji has failed this forum and youngjet will put all of their hopes in stemson. Let’s see in 2040

 

[RolfLeeBuckler]

I assume the next video of YoungJet will be „I talked to alexey terkhish and he told me that Stemson will be on the market in end of 2021 but it will be very expensive (only for millionaires and entertainer)“

 

[werefckd]

At least Dr. Terkiskh and the CEO of Stemson are talking directly to the media often, so we don't need to get our news second hand from clickbaity youtubers. Let's hope things keep that day.

 

[Ghc]

Maybe there are many small anonymous companies in the world that work on hair cloning that we never heard of (pls don't destroy my copes).

 

[nahte42]

I just glanced over (again) the interview Organ Tech gave to HairlossTalk in 2016 and back them they seemed so confident and knowledgeable about most of the parts of their research. It's a shame 4 years after that they close shop and become radio silent. I really think they had some legit breakthroughs and I hope they are not lost with the shutdown of the company. Creating new hairs from scratch must be so freaking hard.

Uh I don't think so. They created new hairs from scratch over a decade ago. There's images of it transplanted into mice that most of us have seen.

The inability to commercialize the technology that they clearly had developed over 10 years ago is pretty pathetic. Unless I'm missing something. But if my memory is correct I'm not.

 

[Tom4362]

Uh I don't think so. They created new hairs from scratch over a decade ago. There's images of it transplanted into mice that most of us have seen.

The inability to commercialize the technology that they clearly had developed over 10 years ago is pretty pathetic. Unless I'm missing something. But if my memory is correct I'm not.

You do not seem to acknowledge the well established fact that humans != mice

 

[nahte42]

You do not seem to acknowledge the well established fact that humans != mice

I didn't say anything about that. The comment was that cloning hairs must be proving to be difficult. I'm saying no; this was done over a decade ago. The process of creating the new hairs.

Implanting them in the human scalp is a separate discussion.

 

[not_bald]

I sincerely hope it happens in order to heal some troubled minds here. It wouldn’t bother me to regain my hair too, it once was my one and only concern in life. However, it’s more possible for you to become a mouse than receive 100k hair strands implanted.

 

[nahte42]

I sincerely hope it happens in order to heal some troubled minds here. It wouldn’t bother me to regain my hair too, it once was my one and only concern in life. However, it’s more possible for you to become a mouse than receive 100k hair strands implanted.

Where do I read about how to become a mouse... would rather be a mouse than live the rest of my life as a diseased looking bald guy.

 

[werefckd]

Uh I don't think so. They created new hairs from scratch over a decade ago. There's images of it transplanted into mice that most of us have seen.

The inability to commercialize the technology that they clearly had developed over 10 years ago is pretty pathetic. Unless I'm missing something. But if my memory is correct I'm not.

The main problem is not creating hairs from scratch with stem cells per se, it is creating hairs from scratch using EXPANDED stem cells. And to make them look natural.

 

[RolfLeeBuckler]

https://austinpublishinggroup.com/dental-disorders/download.php?file=fulltext/jdod-v6-id1146.pdf

Hey @jan miedza can you please explain me:

Why does Takashi Tsuji publish a paper on 25 June 2020 „Functional Tooth Regeneration as a Next-Generation Therapy“ with a co-Autor If organ technologies is dead?


Ikeda E1,2, Nakagawa M1,2, Ogawa M1,3, Takeo M1 and Tsuji T1*
1RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, Japan
2Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara-shi, Nara, Japan 3Organ Technologies Inc., Tokyo, Japan
*Corresponding author: Takashi Tsuji, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Hyogo, Japan

 

[werefckd]

https://austinpublishinggroup.com/dental-disorders/download.php?file=fulltext/jdod-v6-id1146.pdf

Hey @jan miedza can you please explain me:

Why does Takashi Tsuji publish a paper on 25 June 2020 „Functional Tooth Regeneration as a Next-Generation Therapy“ with a co-Autor If organ technologies is dead?


Ikeda E1,2, Nakagawa M1,2, Ogawa M1,3, Takeo M1 and Tsuji T1*
1RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, Japan
2Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara-shi, Nara, Japan 3Organ Technologies Inc., Tokyo, Japan
*Corresponding author: Takashi Tsuji, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Hyogo, Japan

It means Ogawa was representing the institutions Riken and Organ (hence "1,3" after his name) during the time of research, which happened before Organ closed its doors.

Organ is done man, and so is our hope of Tsuji releasing anything commercial in the next 10 years (if ever).

 

[nahte42]

I don't believe that it's simply done. That just doesn't make sense. All the work, being this close to making it happen, and now a dead end for another decade? Doesn't add up?

 

[MeDK]

I don't believe that it's simply done. That just doesn't make sense. All the work, being this close to making it happen, and now a dead end for another decade? Doesn't add up?

I dont know if it's the correct number. But it's like 90% of phase 3 clinical research that fails to come to market release.

And tsuji weren't even on phase 1 yet. Not even proof of concept in humans

 

[nahte42]

I dont know if it's the correct number. But it's like 90% of phase 3 clinical research that fails to come to market release.

And tsuji weren't even on phase 1 yet. Not even proof of concept in humans

Can someone put into simple words what exactly the challenges are with implanting the cloned follicles? They had the cloning tech over a decade ago. They replicate actual follicles by simulating how the follicles are created before birth. They are exactly like the hair follicles on the current back of the head. At that point it seems like it's literally a transplant with unlimited hair bank. So why such trouble getting this to market?

 

[werefckd]

Can someone put into simple words what exactly the challenges are with implanting the cloned follicles? They had the cloning tech over a decade ago. They replicate actual follicles by simulating how the follicles are created before birth. They are exactly like the hair follicles on the current back of the head. At that point it seems like it's literally a transplant with unlimited hair bank. So why such trouble getting this to market?

They didn't have a cloning tech a decade ago. If you read their original study from 2012 what they did was: extract a hair, get stem cells from it, create a new hair from those stem cells.

So there was no multiplication: you lose a hair to get the stem cells and get a new one from it. Net effect is zero.

The next step would be to multiply those stem cells from the extracted hairs, so you could get many new hairs from one. This is where I think they failed. When you expand those stem cells they lose their properties and fail to create a new hair.

 

[nahte42]

They didn't have a cloning tech a decade ago. If you read their original study from 2012 what they did was: extract a hair, get stem cells from it, create a new hair from those stem cells.

So there was no multiplication: you lose a hair to get the stem cells and get a new one from it. Net effect is zero.

The next step would be to multiply those stem cells from the extracted hairs, so you could get many new hairs from one. This is where I think they failed. When you expand those stem cells they lose their properties and fail to create a new hair.

Ah. That makes sense. Yeah, because if true cloning were a fully real thing right now you'd think we'd hear so much more about it.

Well, without the ability to clone an unlimited number of grafts in sight, the baldness solution is totally screwed. So so sad.

 

[werefckd]

Ah. That makes sense. Yeah, because if true cloning were a fully real thing right now you'd think we'd hear so much more about it.

Well, without the ability to clone an unlimited number of grafts in sight, the baldness solution is totally screwed. So so sad.

The people at Stemson have a different approach that seems to be working, or so they claim. They are using iPS cells, very interesting stuff. And they are well funded so I guess in about 2-3 years we will know for sure if they really solved the puzzle or not.

 

[coolio]

The cell replication issue has been the holdup for like 15 years now. They can multiply cells and produce new hairs just fine, but the donor cells only last a few rounds before losing their function.