Fevipiprant Has Been Postponed For 2020. (reddit Tressless Post)

[SimonC]

I have being using cetirizine topical for 5 % and I am extremly surprise for the results so far. Even with all the med I take and I have being taking for all this year, cetirizine is making grew hair on the lost hairline. So I know PDG2 block is the answer.
But yes, if it cross the blood barrier we are fucked. But, may be seti or fevi could be use it topical and, luckily , will not be absorve systemic, or not all.

Why do you think that cetirizine works? You have pretty much aggressive regimen, maybe dutasteride + spironolactone + Min do their job?
No offense, man. Just interesting in your opinion.

 

[HairCook]

Sleep disturbance is already a common and well known side effect on Setipiprant. The drug is not even out yet and we already know it has side effects.

Unless Fevipiprant does not cross the BBB and does not have those side effects, it's just as useless. Nobody is going to tolerate being an insomniac and waking up dead tired.

We are waiting for YEARS for drugs we already know are going to f*** us up and won't be any better than what we have? Are these scientists out of their f*****g minds?

If they can't make at least a SIDE-FREE maintenance drug by 2020 (I know it's not primarily for hair loss), then stop the research, give the money back to charity and kill yourself.

It is not going to f*** you up. PGD2 is involved with sleep induction, nothling like quality or f*****g with your REM.
And that can be fixed. Westonci mentioned even possible fixes ppl on private forum worked out.

Also this issue doesnt happen with an optimized vehicle topically.
Westonci has been taking it even orally for months and didnt really have those issue.
Seti was anyways well-tolerated in its study for asthma, just cause some ppl here wake up at night doesnt mean anything.
There is a reason cots bother running the study.

Evidence ? Lol, here you have the evidences :
A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia. :
https://www.ncbi.nlm.nih.gov/pubmed/28604133

I don't own you a sh*t, I don't need to prove you anything. Who the f*** you think you are ?
Again, you don't even ask a " PLEASE ". f*** you dude, with your sh*t attitude .

Would you please post before-after pictures?

The thing is, before that study even happened, people in german forums tested cetirizine at 1% topically and shaved their heads with it in exchange for a few venus hairs.

The pictures in the cetirizine study are not great either, they look more like combed over.

 

[heyhey]

I concur that certizine works a bit atleast, i have used it for two months and it did cut the shedding by about 70%, i do 3 ml a day.

 

[jamesbooker1975]

Why do you think that cetirizine works? You have pretty much aggressive regimen, maybe dutasteride + spironolactone + Min do their job?
No offense, man. Just interesting in your opinion.

Why do you think that cetirizine works? You have pretty much aggressive regimen, maybe dutasteride + spironolactone + Min do their job?
No offense, man. Just interesting in your opinion.

If you read my post :
I stoped all dutasteride 6 month ago.
All this " agresive " regimen is the same for many, many, many years ago. For example, I use minoxidil none stop since 1998 .
I see new hair growth, terminal hair, in place I did not had any hair since I was 15 years old, I am 39 years old now.

 

[jamesbooker1975]

I knew you would pull this sh*t. I tried to lob it to you, but it appears that you can't read. Take another look at my original post:

>Well DUDE you are the one making claims (it worked for you) online without providing evidence (pics), so first of all, the burden of proof is on you.

The claim that I was referring to was there in the first parentheses and the evidence naturally requested for said claim was in the second set parentheses. It's common sense. I already know there are papers on cetrizine. They made a claim, and they provided evidence - it's in the paper. I was talking about what YOU are saying about yourself.


Yeah fair enough you don't owe me anything.

You don't seem to realize the irony of telling me I have a sh*t attitude for plainly calling out the stupidity you insist on spreading on this forum.

My attitude is fine. It's YOU that I don't like. So "PLEASE" f*** right off.

Dude, Nobody care what you say, it is useless your attitude . I received enought pm to show that people care about what I did post.

 

[d3nt3dsh0v3l]

Dude, Nobody care what you say, it is useless your attitude . I received enought pm to show that people care about what I did post.

Yeah, I suppose the peoples' interest is why you're sitting here like an asshat asking others to say "PLEASE."
Cool, thanks for the tips on attitude.

 

[jgray201]

Dude, Nobody care what you say, it is useless your attitude . I received enought pm to show that people care about what I did post.

Hey mate im using 2% topical. What vehicle you using?

 

[Pelopeleon]

This is probably the worst hairloss new of 2018.

 

[Badbald]

f*****g FDA, its got to be typical over cautious bullshit thats why it always takes them around 10 years to pass anything, either this or trump has postponed it realising it does work and wants other bald people to exist along side him.

It makes me think enough of this bureaucratic non sense, maybe we should do an international crowd fund to get this efficiently double blind placebo tested in a European lab where it can also be made and sold to people that want a chance of not loosing their hair and life because of out dated slow procedure. If we already know the compounds it wouldn't take long to get it tested for immediate sides I can imagine far less then 2 years ( which will probably be extended again)

....I think i know a few people that would happily volunteer for the testing at least.

 

[jamesbooker1975]

Hey mate im using 2% topical. What vehicle you using?

I buy the oral drops 1 % , it have almost the same vehicles than topical.
If you made a topical, I suggest you to don't use ethanol, use water ( 80-90% and the rest of propilen glycol ) .
I know the study used ethanol, but there also studies showing that ethanol degrade the cetirizine.

 

[jamesbooker1975]

f*****g FDA, its got to be typical over cautious bullshit thats why it always takes them around 10 years to pass anything, either this or trump has postponed it realising it does work and wants other bald people to exist along side him.

It makes me think enough of this bureaucratic non sense, maybe we should do an international crowd fund to get this efficiently double blind placebo tested in a European lab where it can also be made and sold to people that want a chance of not loosing their hair and life because of out dated slow procedure. If we already know the compounds it wouldn't take long to get it tested for immediate sides I can imagine far less then 2 years ( which will probably be extended again)

....I think i know a few people that would happily volunteer for the testing at least.

Worst part is that when an already approved drugs shows that it have tons of side effect, from omeprazol to finasteride, they don't banned it .
FDA is now an useless organism . Not even talk about crap generic like the Ambien they approved .

 

[jgray201]

I buy the oral drops 1 % , it have almost the same vehicles than topical.
If you made a topical, I suggest you to don't use ethanol, use water ( 80-90% and the rest of propilen glycol ) .
I know the study used ethanol, but there also studies showing that ethanol degrade the cetirizine.

I am using 2% with 50/50 distilled water and propylene glycol. Bit greasy but works well!

 

[jamesbooker1975]

I am using 2% with 50/50 distilled water and propylene glycol. Bit greasy but works well!

May be you can use less PG, I think it is too much, even the worst minoxidil formulation use 40 % . To be hones I don't even know if in this case PG is necesary, since it is use it cause almost none substance have the high waters solubility of cetirizine .
Do you crush the pills or buy pure powder ?
thanks

 

[Trax1]

So, Here you say about using of 5%

have being using cetirizine topical for 5 % and I am extremly surprise for the results so far.

Next you say about 1%

I buy the oral drops 1 % , it have almost the same vehicles than topical.

What's up, you did forgot your story that you tell a few days ago, and now imagine another one ?

 

[jamesbooker1975]

So, Here you say about using of 5%


Next you say about 1%



What's up, you did forgot your story that you tell a few days ago, and now imagine another one ?

1 % dude. Really, get a life.

 

[jgray201]

May be you can use less PG, I think it is too much, even the worst minoxidil formulation use 40 % . To be hones I don't even know if in this case PG is necesary, since it is use it cause almost none substance have the high waters solubility of cetirizine .
Do you crush the pills or buy pure powder ?
thanks

Yeah i might reduce the pg, but my scalp doesnt react at all to PG and i want to make sure the absorption is good. I use powder.

 

[heyhey]

So.. I am thinking of doing either 500mg or 750mg of seti each day, will that do any good?

 

[jamesbooker1975]

So.. I am thinking of doing either 500mg or 750mg of seti each day, will that do any good?

Probably, not .

 

[heyhey]

Probably, not .

I see, i am only looking for mantainance it wont do that either?

 

[SamFT]

I see, i am only looking for mantainance it wont do that either?

Try it. Pigeon is doing 200mg and is reporting maintenance. I’m thinking about starting 500mg a day too cause I don’t feel like waiting for Aclaris trial when there is s chance it ain’t gonna do JAK sh*t.