Hey guys.
Today I have some more great news for you. I met up with a Singapore team who compared dermal papillae cells from balding to permanent zone of the scalp and found that transcriptosome differences may be responsible for androgen sensitivity of DP cells in the balding zone!
So I asked what's their solution to this problem? Would you have to use a retrovirus to correct these genetic differences (ie. Gene therapy)?
They pointed out that gene therapy is still 1-2 decades away and its safety is still very controversial. They hypothesised a different approach! Once they perform the genomics and proteomics studies they will hone in on the exact proteins needed to be blocked and simply by inhibiting protein synthesis they will stop androgen sensitivity in the balding scalp!
So in other words a permanent halt of hair miniaturisation! Don't forget that finasteride works in a similar manner per say by blocking a protein called 5 alpha reductase which converts testosterone to DHT. Their method will target a different protein which is responsible for telling DP cells to express androgen receptors which is detrimental to their health.
Timeline wise, they're hoping the proteomics should be conclouded in the next 2 years. Fascinating stuff.
She is emailing me a copy of her poster and I'll share it as soon as I get it