German Researchers (MalliaBioTech) Find CD83-Based Molecule Grows New Hairs, wins M4 Award
- Thread starter kingjohn
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Or regenerates old flaccid follicles thought to be dead
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Anything that could repair existing hair follicles would also be a game-changer. Nothing is on the market that can do that.
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Yet there are numerous reports of people growing hair back via microneedling and minoxidil.
You’re correct that there’s nothing known on the market that can repair follicles.
But unless you’ve been living on a deserted island without internet access, and you’ve somehow missed all the photos of slick balding brothers growing hair back, I don’t know how anybody could say the follicles are truly dead as opposed to dormant.
Guess we’ll find out in 1-5 years
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The way I read it, it works for hormonal hair loss, so I guess it is repairing hair follicles to regrow. Will it generate new follicles where they're gone or never existed? It would be a miracle. What I am looking for is something that grows completely new follicles. So far the best players in the game from my limited research are Stemson, Riken and Han Bio. I, like most people on this forum are disgusted they test everything on mice first. Mice, from what I read, anything easily regrows their hair. I think it's a good idea they skip the mice in these clinical trials and go straight to pigs. Then the preclinical trials, clinical trials (if they make it that far and the company doesn't fold), government clearance and then the business aspect of who gets what make it an eternity before anything comes to market. It's a travesty! I watched the video (I don't speak German) but saw that bald guy try the potion on his head. So would it kill them to try it on others who are willing? Why every darn thing has bureaucracy, costs of (pre/clinical) trials and ownership of profits is delaying progress. Even in countries that have new laws to fast track medical advances still have long waits. The thing I don't like is this stuff has to keep being applied to work. It seems like more of the same unless it really does generate new follicles which never existed.
Another thing, the word "Mallia" as in Malliabiotech means "hair" in Greek if you didn't know. Everyone loves to call things after Greek words.
In vivo research on hair loss and regrowth was performed so far on mice, rats, hamsters, rabbits and sheep in laboratory conditions [88,89,90,91]. Lately, the interest in hair growth promoting agents has grown considerably and in the attempt to discover an ideal therapy for alopecia, new treatments have been studied even in stump-tailed macaque [92]. Still, researchers must take into consideration the differences between species regarding the follicular function and limited androgen-sensitive models [93]. The periodic intervals of rodent hair cycles, particularly the duration of the anagen phase are much more consistent and less susceptible to iatrogenic influences [94].
The normal hair cycling, including growth waves and hormonal control were studied on Wistar Bratislava rats and mice [95]. The black mouse C57BL/6 was used for the skin-free pigment and early visible pigmented tips of new anagen regrowth [91,96]. The C3H mouse model was the most widely reported for hair growth promotion, even thought the increased hair density of the animal and the wave pattern hair cycle progression presented disadvantages [95,96,97]. Laser therapy applied in C3H mouse, 20 second daily, 3 times per week, induced a much longer growth phase, after only 2 weeks of treatment, with most of the follicles from the tested area being in anagen hair growth phase [98].
The androgen action upon the hair follicles has been studied on spontaneous and genetically engineered nude mutant mice. Immunodeficient mice (with T and B cells deficiencies) were used as models for autoimmune disease mechanisms and androgenetic alopecia studies [96]. Also, by inhibiting the rejection of foreign skin, human skin grafts were applied and even rat dermal papillas continued to produce hair after reimplantation in vivo on a rat model [99,100,101].
Recently scientists discovered that a certain progenitor cell population in mice is analogous to the human cells. These mature cells were tested by injection on immunodeficient mice animal model and the results showed the development of new hair follicles and increased hair regrowth [98].
Hair loss and regeneration performed on animal models - PMC
Research in the field of reversal hair loss remains a challenging subject. As Minoxidil 2% or 5% and Finasteride are so far the only FDA approved topical treatments for inducing hair regrowth, research is necessary in order to improve therapeutical ...
www.ncbi.nlm.nih.gov
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Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin
Human scalp skin and hair follicles (HFs) are extra-pituitary sources of prolactin (PRL). However, the intracutaneous regulation of PRL remains poorly understood. Therefore we investigated whether well-recognized regulators of pituitary PRL expression, which also impact on human skin physiology...
CD83 cells stimulate release of many cytokines like interferon and TNF. I really like this research because it seems a bit upstream from what hopemedicine is targeting as well
“Interferon (IFN) γ increased PRL IR in the epithelium of human HFs (p = 0.044) while tumour necrosis factor (TNF) α decreased both PRL and PRLR IR. This study identifies substance P, TNFα and IFNγ as novel modulators of PRL and PRLR expression in human skin”
Ralf paus is researcher in this study