Group Buy: ARV-110 PROTAC+ WAY-200070 ERb Agonist

[Zon Ama]

Hey, are all of you guys are planning to add WAY and ARV? So there will be no SMI-only user left?

 

[Numerous_Bet_3027]

Hey, are all of you guys are planning to add WAY and ARV? So there will be no SMI-only user left?

There will probably be SMI-only users left but it will be hard to track results. Many prefer cocktails

 

[GabberHead]

Yes, no need to buy both. They are separate buys being conducted at the same time

Great, count me in

 

[Chads don't bald]

Can someone explain how an AR degrader won't be really bad for you?

Looking it up, ARs play a role as a DNA binding transcription factor. Would this effect gene expression in our cells? What are the consequences?

 

[Zon Ama]

There will probably be SMI-only users left but it will be hard to track results. Many prefer cocktails

Damn. Then its over for SMI, I guess. We wont be able to see if SMI only works in a time period of 6+ months.

 

[Redgate]

Can someone explain how an AR degrader won't be really bad for you?

Looking it up, ARs play a role as a DNA binding transcription factor. Would this effect gene expression in our cells? What are the consequences?

ARs play many important roles in the body, but you're only targeting those in the hair follicles, which are overexpressed compared to non-balding follicles anyway.

 

[TheBlackSuit]

Important question: For people who live within the EU, will the package be send from a country within EU or outside of EU. Customs will f*** me hard if it's from outside EU like China .......

I will maybe join after I see the first results from other people.

 

[hairlossisevil]

Important question: For people who live within the EU, will the package be send from a country within EU or outside of EU. Customs will f*** me hard if it's from outside EU like China .......

I will maybe join after I see the first results from other people.

Pretty sure all of this buys are from China.

 

[Kitedude]

I want in Pegasus

 

[DAVAT]

Just a question, is it not worth waiting to see what the SMI results are first before adding other stuff?
Or were there no notable results?

 

[Zon Ama]

Base on the fact only 1 person shared results , and the result were meh. I would say dont hold your breath for it.

???
I saw results of at least 5 guys.

 

[Ollie]

Base on the fact only 1 person shared results , and the result were meh. I would say dont hold your breath for it.

Dude he was on SMI only and regrew terminals out of his temples

 

[Chads don't bald]

Absolutely it would. That's why you have hair loss because your gene expression is changed. We're trying to reverse those changes. The consequences of doing this locally in the scalp are nothing but beneficial.

Is there not systemic absorption though?

And anyways, even disregarding hair loss, apparently this is being developed for the prostate. How will they deliver it selectively to the prostate so it doesn't affect androgen receptors elsewhere in the body?

I guess what I'm asking is, I know it is safe, but why is it safe?

 

[Numerous_Bet_3027]

Just a question, is it not worth waiting to see what the SMI results are first before adding other stuff?
Or were there no notable results?

It would be but people are impatient. The GB was pretty big for SMI, if it helps in a major way we'll know it soon enough.

 

[Chads don't bald]

It won't be delivered selectively to the prostate. For that indication it will have systemic side effects because they have to flood your whole body with the compound.

So basically even if AR's are degraded throughout the entire body, it doesn't actually have any detrimental side effects that's why they're able to develop this treatment for the prostate.

In that case, would oral be superior to topical for hair loss?

 

[otann]

So basically even if AR's are degraded throughout the entire body, it doesn't actually have any detrimental side effects that's why they're able to develop this treatment for the prostate.

In that case, would oral be superior to topical for hair loss?

The person to whom you're replying is not arguing that systemic AR degradation is safe, they are saying that the systemic AR degradation resulting from topical application to the scalp is minimal. Since there is no similarly practicable way to deliver a concentrated dose to the prostate, oral administration (which is less selective and thus necessarily causes non-negligible systemic degradation and adverse effects) is needed for people dealing with cancer. That is the typical trade-off when treating cancers with anti-androgens.

 

[5minutesbeforemiracle]

Base on the fact only 1 person shared results , and the result were meh. I would say dont hold your breath for it.

Well looks like there's some more context to it than that. I'd seen some posts referencing the fact that most of them ran out of the smi fairly quickly... just because it's been 6months or so since their first group buy it doesn't mean they were using it for 6months.
Anyway it's all experimental, these guys are doing a great job researching all this stuff and they deserve props whether it works or not. If customs in my country weren't so strict I'd have participated in some of these group buys, especially SMI.

 

[Throwaway94]

The first round was a flop because we all underestimated the oral dosage and ran out within a month or two. Our second batch is on its way and we'll have results starting around the new year all going well, as we've all bought enough to last 3-6 months at a meaningful dose.

Can everyone just calm the f*** down, just because we're pursuing compounds targeting the AR and ER doesn't mean we've given up on the PRLR, we just need to get our hands on our first proper batch to have a better idea of how well it works.

 

[Chads don't bald]

The person to whom you're replying is not arguing that systemic AR degradation is safe, they are saying that the systemic AR degradation resulting from topical application to the scalp is minimal. Since there is no similarly practicable way to deliver a concentrated dose to the prostate, oral administration (which is less selective and thus necessarily causes non-negligible systemic degradation and adverse effects) is needed for people dealing with cancer. That is the typical trade-off when treating cancers with anti-androgens.

Ah ok I'm understanding now. I was wondering why the company would be developing this for oral delivery if it wasn't safe, but I guess they just expect patients to power thru the sides

Any idea what the sides would be of systemic AR degradation?

 

[supermusic]

You say that one of the effects is that it improves the appearance of the skin. Isnt that a clear indication of the systematic estrogenic effects?