Group Buy: ARV-110 PROTAC+ WAY-200070 ERb Agonist

[baldlygoing]

Is anyone on finasteride or dutasteride going to drop it once starting this? Personally would love to be able to drop finasteride but a little nervous.

 

[Ralph Wiggum]

Is anyone on finasteride or dutasteride going to drop it once starting this? Personally would love to be able to drop finasteride but a little nervous.

Not a smart move at all, man.

 

[Left4bald]

hi i would like to participate in this group buy

 

[norwoodVictim]

Yes, assuming ARV eliminates all ARs in your hair (again, ASSUMING), even if you injected DHT directly into your scalp it shouldn't have any effect, but as for what % of the scalp's ARs would be degraded at what dose and application frequency, I highly doubt anyone can answer that question.

Thanks for the reply. When the word "degraded" is used in this context, it means the specific ARs that are degraded is left impotent, right? Like no androgens can attach itself to it. Or does degraded in this context mean less androgens are able to to attach themselves to the degraded AR?

 

[Dimitri001]

Thanks for the reply. When the word "degraded" is used in this context, it means the specific ARs that are degraded is left impotent, right? Like no androgens can attach itself to it. Or does degraded in this context mean less androgens are able to to attach themselves to the degraded AR?

I'm not an expert, but my understanding was that the AR is destroyed. But, again, IDK and maybe I'm wrong.

 

[Dimitri001]

I'm just wondering how I would theoretically apply ARV to a full *** head of hair for maintenance

My head forest gonna be so thick after HMI that ARV has no chance of reaching my scalp lol

If you regrow your hair with HMI, my assumption would be that you wouldn't need a maintenance drug. Remember, the monkeys maintained their hair for years after stopping HMI.

 

[Gegen]

Is anyone on finasteride or dutasteride going to drop it once starting this? Personally would love to be able to drop finasteride but a little nervous.

I think some people who will test it in the incoming months will drop finasteride/dutasteride. If they don't lose their hair, you know what you'll have to do.

 

[Gegen]

I don't know if it have been said here, but the deadline for the groupbuy is Sunday (end of the day).

 

[Gegen]

They probbly dont have the kins of male pattern baldness we have…

They have. However, they didn't maintain all the hair they regrown, but most of it, so you would need some maintenance drug anyway if you want to keep your NW1.

 

[Most_attention]

will they be able to ship to australia? i'd be interested in joining the group buy if there are still spots available!

 

[inmyhead]

will they be able to ship to australia? i'd be interested in joining the group buy if there are still spots available!

They can ship anywhere. Problem is your customs.

 

[300]

I don't know if it have been said here, but the deadline for the groupbuy is Sunday (end of the day).

Why Sunday?Why don't you extend it a few more days?

 

[Dimitri001]

They have. However, they didn't maintain all the hair they regrown, but most of it, so you would need some maintenance drug anyway if you want to keep your NW1.

I guess it will come down to what's cheaper and more tolerable with regards to sides - shooting up with a course of HMI every few years or being on some kinda AA permanently. I suspect HMI will win on sides, but I'm not sure who wins price-wise.

There's also effectiveness, of course. HMI should beat most AAs on effectiveness, except maybe an AR degrader like this.

 

[5minutesbeforemiracle]

Everything is a risk if it wasn't tried before.The worst that can happen is we spent money for nothing.

That is definitely not the worst that can happen when trying untested drugs, wtf.

 

[Jakejr]

We are organizing a group buy now for a PROTAC androgen receptor degrader and a highly selective estrogen receptor beta agonist. Everyone is welcome to join. The combination of these two compounds should give hair regrowth comparable to traditional mtf regimens but without the sexual side effects. I will start with a brief overview of how each of these compounds work.

ARV-110 is a potent PROTAC. It recruits the AR (androgen receptor) to the E3 ubiquitan ligase promting its degradation so that DHT cannot bind to it. This is temporary because new receptors are generated, but until that happens it eliminates AR activation. This is the first step that's required to treat hair loss. Kintor is currently developing a similar PROTAC to treat Androgenetic Alopecia, and they expect it to have no side effects.

WAY-200070 is a potent and selective ERβ (estrogen receptor beta ) agonist. It binds to ERβ without binding to ERα (estrogen receptor alpha) except at very high doses. This is perfect for us because ERβ is believed to mediate 17β-estradiol-induced hair growth, and does not have any feminizing effects. Things like breast growth and fat distribution etc., are believed to be controlled by ERα. ERβ activation actually silences ERα so it is expected to have the opposite effect and actually reduce or inhibit gyno while still promoting hair growth.

We have seen tremendous hair regrowth, and in some cases complete reversal of hair loss in male to female transgenders who use potent AR antagonists combined with 17β-estradiol. CIS men can't do that of course because the side effects are unacceptable. These two new compounds are available to us now and should allow us to reproduce the hair growth results of such feminizing treatments without the feminization aspect. Here are some of the examples of hair growth from using estrogen and potent AR antagonists, and what type of regrowth is expected from the combination of these two compounds at the proper dose.

View attachment 169266View attachment 169265View attachment 169264View attachment 169263View attachment 169262View attachment 169261

WAY-200070 is already being used by a handful of people on discord and they are reporting new vellus hairs in their temples. The people currently trialing are using concentrations between .1-.5% and applying it once to twice daily. The only side effects noted so far are hives/rash at the site of application in some and better skin generally. Now we are ordering more WAY-200070, and getting ARV-110 to go with it for the perfect combination. ARV-110 is being developed for castration resistant prostate cancer. The oral dose is 280-420mg daily, and almost totally suppresses the AR systemically at that dose. We will use just a small fraction of that dose topically. No one can guarantee what dose is safe and effective for either of these compounds, but most of us on discord are planning to use ARV-110 at .1% once a week. It has a 110 hour half-life so daily dosing is unnecessary. That's just 1mg/ml, or approximately 1/2000th of the oral dose for prostate cancer. Oral bioavailability is estimated at 25%. We estimate that only 5% of the topical dose will be absorbed systemically. That would give a systemic concentration that is 1/10,000th the concentration used in trials to shutdown the AR. This dose should not give any side effects. Personally I plan to use it daily so that I can just mix it together with WAY-200070. I will still use a concentration of .05-.1%, so I will be using more than others, about 7-14mg per week. Even this dose will give a systemic concentration that is around 1/700th that required to silence the AR systemically. One mg or less is impossible for most people to measure, so a stock solution may be required if you're using smaller and infrequent doses.

Here I will post further information on both compounds. ARV-110 has a large molecular weight of 812 Daltons so DMSO or microneedling will be required for topical absorption, but the large weight also helps to limit systemic absorption. At an oral dose of 35mg daily no adverse events were reported.

ARV-110 Phase 1/2 Dose Escalation: Interim Update

View attachment 169272


WAY-200070 is 67-fold more selective for ERβ over ERα. Erteberal has been trialed in humans for schizoprhenia at up to 150mg orally, and no sexual side effects were noted, leaving them to conclude that the doses used do not activate ERα. Since it's about 10x less potent there should be no activation of ERα at 15mg daily doses of WAY-200070. I am currently using this dose.

View attachment 169273

Price:
WAY-200070 is $130/g. Must order in increments of 1g.
ARV-110 is $130/200mg. Must order in increments of 200mg.
Shipping is $55 with a reship policy if your order is not received.

If you would like to participate in this group buy let us know here.

Hi
I am intrigued by your research.
I will participate. I will purchase minimum of both. We are talking about very small amounts. Do the math for me for both.
The amount purchased & recommended dose. To break up 1 gram or less into 200 parts is a bit tricky. But tell me the purchase amount & daily/weekly dose. I will figure out the transmission method.
thanks

 

[MrSnow]

hello, i am french, can i have the link of discord please ?

Thanks a lot

 

[MrSnow]

which drugs i need for this type of results please ?

I don't understand all you meant because i am french and i am 19 years

i want to teak your things, but in which website i need rent it please ?

 

[Micky_007]

Hi guys,

I'm interested in participating in the group buy for both the WAY and ARV-110.

Also, I've been sharing the link to this thread from @pegasus2 about ARV-110 and WAY on as many threads as I could. I posted them on about 10 different RU58841 Threads, because people who bought and used RU are most likely to buy and use ARV-110 and WAY as well.

So ignore those posts if you see them in multiple different threads lol. Just helping spread awareness.

That way we get as many people as possible in the group buy and as many people as possible trialing this out so we can see results from a large amount of people to help form a good idea of the effectiveness.

 

[MrSnow]

Start with finasteride , minoxidil and derma roller. Go to you doctor to get those drug and info.

i take it
but i want other things like on this post
can you help me
i want to take drugs for my hair

 

[Adri23]

Where is the discord? I'm not planning to start this yet, but it would be interesting to see the before and after six month later