Had A Radical Idea In The Library’s This Morning

[barfacan]

Just leaving this here: Why don't they just measure 5ar2 activity? this study suggests that DHT may not be a reliable proxy for 5ar2 activity specifically

http://clinchem.aaccjnls.org/content/59/5/798

this may be too offtopic at this point, ill cross post it to the polichem thread

 

[BaldAndBalder]

I still believe that reducing DHT is the "wrong" way to fix the problem, dht isn't the problem its the follicles over sensitivity to it that is.
We should "fix" the follicles themselves instead of messing around with something that isn't broken in the first place, men who became impotent because of finasteride/dutasteride learned it the hard way.

 

[SuperDPAsteve]

thats what replace is trying to do

Didn’t sheisido just finish phase 2? Like in Japanese terms they should be ready for commercialization unless something went wrong

 

[Kevin19888]

Greetings friends. Where can I buy mesh?

 

[ffar1989]

that wouldn't happen if it doesn't go systemic though.. and I would strongly advice against an estrogen blocker in any case, that can really f*** you up. did you get bloodwork done at the time or is this just speculation that your estrogen rose up?

No I did not. It is just my speculation. For first 11 weeks my life was amazing, very low sides like watery sperm but thst was only issue I have problem with. Besides increase libido like I was 16, help deal with depressive moods because it gave me little so called brain fog. It may sound sh*t but for someone who is suffering for OCD it was amazing experience.

And hair... Insane results with only 0.25 mg of dosage per day. I was getting Brad Pitt hairs... Out of nowhere, penis was dead, zero erection and nightmare start. Good for me I have fully recovered in 12 days. That's why I put huge hope for Fevipiprant.

Extra kick of estrogen is just my guess but what else it could be.

 

[BalderBaldyBald]

But finasteride inhibits the 5ar2 enzyme, it does not prevent the DHT hormone from docking to the receptor. DHT is still being produced within the body, can't it find its way to the scalp?

edit: i'm also quite wary of using serum dht as a reliable indicator, because we have 2 forms of 5AR, simply measuring serum DHT doesn't indicate which of the two enzyme's produced it. The reason this may be important is that 5AR most likely has other functions than just T ---> DHT conversion. Are there are other lab tests which directly measure 5ar2 activity....I know there are a few that measure overall 5AR, but im not sure if they distinguish between the two.... Is this just splitting hairs? If only Bryan were still alive, he would have definitely schooled me.

Quite hard thing to do
"Several methods were developed for measuring 5a-reductase activities. Tritiated testosterone is incubated with tissue homogenates or with cultured cells and the radiolabeled steroid metabolites are separated by thin layer chromatography or reverse phase chromatography (Maudeldonde et al., 1986; Tamura et al., 1996). Radioactive assays are preferred because the low activity of the enzyme, near the limit of detection of classic spectrophotometric or spectrofluorimetric NADPH monitoring techniques. Here we describe a nonradioactive assay for measuring 5a - reductase activities in cultured cells by a high-resolution chromatography separation of testosterone metabolites and their detection on line, in UV light (214nm)."

This paper is from 2004 tho, but i don't think they can do it with a simple blood sample.
They need a skin biopsy for a starter

 

[SuperDPAsteve]

Greetings friends. Where can I buy mesh?

Any surgical supply store I’d imagine ¯\_(ツ)_/¯

 

[Jakejr]

I must say that’s a creative new suggestion.
I didn’t read everything you said, but you want a doctor to implant a mesh surgically to a human skull?
That will never happen in a million years.
1) No doctor would even attempt it without FDA approval.
2) No company would undertake double blind studies in first place.
3)Then to have it shoot finasteride subdermally, when the exact cause & cure for male pattern baldness is debatable. And side effects are enormous couldn’t happen in USA.
They already have topicals containing finasteride available to experiment with.
Nonetheless you’re thinking & it may lead someone else to another possible treatment/method.

 

[SuperDPAsteve]

I must say that’s a creative new suggestion.
I didn’t read everything you said, but you want a doctor to implant a mesh surgically to a human skull?
That will never happen in a million years.
1) No doctor would even attempt it without FDA approval.
2) No company would undertake double blind studies in first place.
3)Then to have it shoot finasteride subdermally, when the exact cause & cure for male pattern baldness is debatable. And side effects are enormous couldn’t happen in USA.
They already have topicals containing finasteride available to experiment with.
Nonetheless you’re thinking & it may lead someone else to another possible treatment/method.

So to summarize your post: “lol didn’t read, but here is exactly why what I assume you said is wrong”