Hair Follicle Neogenesis Clinical Trial

H

HairOnFire

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PeggyPeterson said:
Just saw an interesting article on neo genesis from John Hopkins that I thought might interest to some

https://clinicaltrials.gov/ct2/show/NCT03491267

It relates to Central Centrifugal Cicatricial Alopecia but I don’t see why it can’t be applicable to Androgenetic Alopecia.
Click to expand...


A brand new study also shows that mild disruption of the scalp via a laser can induce hair growth in humans:

Dermatol Surg. 2018 Aug 9. doi: 10.1097/DSS.0000000000001619. [Epub ahead of print]
Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia.
Meephansan J1, Ungpraphakorn N1, Ponnikorn S2, Suchonwanit P3, Poovorawan Y4.
Author information

Abstract
BACKGROUND:
A new treatment for androgenetic alopecia (Androgenetic Alopecia) is 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth.

OBJECTIVE:
The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with Androgenetic Alopecia.

METHODS:
Twenty-three patients with Androgenetic Alopecia were enrolled. They received 12 treatments at 2-week intervals. A scalp biopsy was performed to evaluate mRNA levels of Wnt10A and IGF-1. Histopathologic samples were collected.

RESULTS:
Significant increases in hair count and shaft diameter that occurred from Month 4 until the end of the study were observed. Histological results showed increases in the follicular unit, anagen hair count, and the anagen:telogen ratio. No up-regulation of Wnt10A and IGF-1 mRNA was observed.

CONCLUSION:
The 1,550-nm Er:Glass fractional laser treatment can increase hair density and shaft diameter in patients with Androgenetic Alopecia. The mechanisms by which 1,550-nm Er:Glass laser treatment induces new hair growth may not be limited to Wnt10A/β-catenin or IGF-1 expression.
 
D

Dave721

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HairOnFire said:
A brand new study also shows that mild disruption of the scalp via a laser can induce hair growth in humans:

Dermatol Surg. 2018 Aug 9. doi: 10.1097/DSS.0000000000001619. [Epub ahead of print]
Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia.
Meephansan J1, Ungpraphakorn N1, Ponnikorn S2, Suchonwanit P3, Poovorawan Y4.
Author information

Abstract
BACKGROUND:
A new treatment for androgenetic alopecia (Androgenetic Alopecia) is 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth.

OBJECTIVE:
The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with Androgenetic Alopecia.

METHODS:
Twenty-three patients with Androgenetic Alopecia were enrolled. They received 12 treatments at 2-week intervals. A scalp biopsy was performed to evaluate mRNA levels of Wnt10A and IGF-1. Histopathologic samples were collected.

RESULTS:
Significant increases in hair count and shaft diameter that occurred from Month 4 until the end of the study were observed. Histological results showed increases in the follicular unit, anagen hair count, and the anagen:telogen ratio. No up-regulation of Wnt10A and IGF-1 mRNA was observed.

CONCLUSION:
The 1,550-nm Er:Glass fractional laser treatment can increase hair density and shaft diameter in patients with Androgenetic Alopecia. The mechanisms by which 1,550-nm Er:Glass laser treatment induces new hair growth may not be limited to Wnt10A/β-catenin or IGF-1 expression.
Click to expand...

Just look over this paper (Its huge). Results were not impressive and the pictures even less so. Guess I'll give them credit for not using tricky light angles.
 
Trichosan

Trichosan

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Armando Jose said:
A recent one

https://www.ncbi.nlm.nih.gov/pubmed/29949176
Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):4000-4008. doi: 10.26355/eurrev_201806_15285.
Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-β and mitochondrial signaling pathway.
Click to expand...

Quick search shows the most efficacious form to be hexane extract as found in brand known as Permixon.
From:
http://inflammation-and-bph.elsevier.cc/how-choose-right-serenoa-repens-extract

Are you thinking topical @Armando Jose ?
 
Armando Jose

Armando Jose

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I use it in my hair lotion, and yes, @alibaba92, the smell is pungent but i mix it with other essential oils
this is the formula
Jojoba esters, Limanthes alba, Borago officinalis, Rosa
moschata, Oenothera biennis, Persea gratísima, Serenoa serrulata,
Butyruspermun parkii, Rosmarinun officinalis, Lavandula officinalis, Melaleuca
alternifolia, Origanum vulgaris, Thymus vulgaris, Laurus nobilis, Anthemis
nobilis, Ocimun basilicum, Salvia officinalis, Mentha piperita, Foeniculum
vulgare, Citrus limonun, Carum petroselinum, Eugenia caryophyllus.
 
T

tomJ

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HairOnFire said:
A brand new study also shows that mild disruption of the scalp via a laser can induce hair growth in humans:

Dermatol Surg. 2018 Aug 9. doi: 10.1097/DSS.0000000000001619. [Epub ahead of print]
Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia.
Meephansan J1, Ungpraphakorn N1, Ponnikorn S2, Suchonwanit P3, Poovorawan Y4.
Author information

Abstract
BACKGROUND:
A new treatment for androgenetic alopecia (Androgenetic Alopecia) is 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth.

OBJECTIVE:
The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with Androgenetic Alopecia.

METHODS:
Twenty-three patients with Androgenetic Alopecia were enrolled. They received 12 treatments at 2-week intervals. A scalp biopsy was performed to evaluate mRNA levels of Wnt10A and IGF-1. Histopathologic samples were collected.

RESULTS:
Significant increases in hair count and shaft diameter that occurred from Month 4 until the end of the study were observed. Histological results showed increases in the follicular unit, anagen hair count, and the anagen:telogen ratio. No up-regulation of Wnt10A and IGF-1 mRNA was observed.

CONCLUSION:
The 1,550-nm Er:Glass fractional laser treatment can increase hair density and shaft diameter in patients with Androgenetic Alopecia. The mechanisms by which 1,550-nm Er:Glass laser treatment induces new hair growth may not be limited to Wnt10A/β-catenin or IGF-1 expression.
Click to expand...
Ok so clearly the laser works to increase density...So why the hell is this not being fast tracked into clinics!!!!! This pisses me off because we have an effective side effect drug free treatment that works, yet it will end up sitting on the sidelines while researchers look for another product that may grow hair!!! I'm really angry. You have something, now let is use it for God's sake!!!
 
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PeggyPeterson

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The study doesn’t wound with microneedling, it employs fancy wounding technique incorporating CO2. I know the length of the trial is long (2025), but this is Johns Hopkins we’re talking about. If POC is expected to be completed by 2025, this will be a long way off! I just wanted to share because it’s shows the direction a reputable institute is taking regarding follicular neo genesis.
 
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tomJ

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PeggyPeterson said:
The study doesn’t wound with microneedling, it employs fancy wounding technique incorporating CO2. I know the length of the trial is long (2025), but this is Johns Hopkins we’re talking about. If POC is expected to be completed by 2025, this will be a long way off! I just wanted to share because it’s shows the direction a reputable institute is taking regarding follicular neo genesis.
Click to expand...
This is actually bad news in my opinion and here is why...garza is a big wig at johns Hopkins. In his younger years Garza worked at Penn under George cotsarelis. I went and saw Garza during that time. But anyway, this tells me that cots abrasion techniques to grow hair are not what they cracked up to be.
 
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Baldybald1

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tomJ said:
This is actually bad news in my opinion and here is why...garza is a big wig at johns Hopkins. In his younger years Garza worked at Penn under George cotsarelis. I went and saw Garza during that time. But anyway, this tells me that cots abrasion techniques to grow hair are not what they cracked up to be.
Click to expand...
That’s true unfortunately
 
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kirklandism

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tomJ said:
This is actually bad news in my opinion and here is why...garza is a big wig at johns Hopkins. In his younger years Garza worked at Penn under George cotsarelis. I went and saw Garza during that time. But anyway, this tells me that cots abrasion techniques to grow hair are not what they cracked up to be.
Click to expand...

Perhaps abrasion of the skin is not enough to induce neogenesis but ablation is?
 
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tomJ

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You may be right. But I would think that cots would of tried this by now. I mean he has been fooling around with this concept for 10 years.
 
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