I have cut out everything that isn't important. Everything I'm on is an integral part of the regimen, and works synergistically with the others. For example, SW keeps PGE2 and dinoprost from being inactivated, and rapamycin inhibits mTOR which hopefully prevents the Wnt agonists from stressing stem cells. I have not begun CHIR99021 or dinoprost yet, I'm still waiting on those in the mail. Maybe I could cut out erlotinib as long as I'm on BIM-I, or vice versa. Epitalon is just a series of 10-20 injections twice a year. I'm also injecting TB-500, BPC-157, thymalin, and soon to be GHK-Cu. Remapping the scalp skin is half the battle. Unless you're transplanting a follicle from the back of the head with its own healthy tissue then it's going to be tough to grow hairs in a fibrotic scalp.
Hh signalling pathway carries unknown risks. There are lots of things that upregulate shh and have been shown to be safe. None of those upregulate it as much as SAG. It could be dangerous, especially if used continuously or if you have cancer. If you have cancer avoid any type of Wnt or Hh agonist. You should definitely get a good check up and run things by your doctor before getting on any regimen that's not OTC. Make sure you don't have heart issues before getting on things like MNX or eplerenone, and no cancer before getting on PGE2 or estrogen. For a young and healthy individual the only real question mark to me is SAG. Topical PGE2 should be safe medium-term, but long-term I wonder if there could be neurological effects if trace amounts are getting to the brain. You want to make sure not to overdose on anything of course, or it could all be dangerous.
CHIR99021 is actually a GSK3b inhibitor, and PGE2 does many things, only one of which is GSK3 phosphorylation. I'm on two anti-androgens because dutasteride only inhibits half of scalp DHT and doesn't block testosterone, which is fine for stopping hair loss, but to get regrowth you want to nuke androgens in the scalp.
If I was going to cut my regimen to the bare bones for simplicity and/or finances, I would cut out the WAY, CHIR, erlotinib, the peptides(epitalon, tb-500, etc.), and maybe dinoprost, although there's some evidence that it works synergistically with PGE2 even though I haven't tried it yet.
