HMI-115 PRLR antibody: The Most Promising Treatment Ever

[Dr sanches]

RU grow hair in monkeys?
Human scalp hair is more complexe than primates.
BTW any shoemaker know that only pig, primates and human skin/leather is similar respect to hair, Splits of these leathers have holes in it due hair fibre and dermal papila is located in the dermis and need trespass, in rest of them hair anchorage are located more external. Other challenge is the asynchronicity of human scal hairs, each hair is not linked to the hair cycle of neighbourgs.

Exactly these people are hyped with cope medicine growing hair in monkeys

 

[Dr sanches]

RU grow hair in monkeys?
Human scalp hair is more complexe than primates.
BTW any shoemaker know that only pig, primates and human skin/leather is similar respect to hair, Splits of these leathers have holes in it due hair fibre and dermal papila is located in the dermis and need trespass, in rest of them hair anchorage are located more external. Other challenge is the asynchronicity of human scal hairs, each hair is not linked to the hair cycle of neighbourgs.

Exactly these people are hyped with cope medicine

 

[Kagaho]

Oh my... Sanches and the sebum guy. Hardcore science lol.

 

[Redgate]

Exactly these people are hyped with cope medicine

all you have to do is read the first posts, but instead you choose to be retarded.

 

[RagnarLothbrok]

 

[Nostro300]

What doctor is going to prescribe an antibody, that only has an approved indication for women, to balding men that are citing a monkey study they read on a hair loss cope forum? Practically you'd have to find someone who posts here.
Also let's not forget that this is extremely expensive and probably more so for endometriosis because they'll rip off insurance (which won't cover off-label scripts)

8 years ago my doctor prescribed me keratin capsules. Basically a "hmm yeah, hair is made of keratin so here you go, + keratin = + hair ...now get out of my office"
I Know that he didn't believe such treatment would ever work but also he didn't want to tell a young man to just shave it bro

 

[waynakyo]

Endocrine Mechanisms of Hair Growth​

Abstract​

The prenatal morphogenesis of hair follicles depends upon a precisely regulated series of molecular genetic processes. Hormones and their receptors play prominent roles in modulating postnatal hair cycling, which recapitulates some aspects of morphogenesis. The responses to androgen are the most obvious of these. The postnatal androgen sensitivity of pilosebaceous units in different skin areas is programmed during prenatal development to permit clinical outcomes such as hirsutism and pattern baldness. Thyroid hormone, glucocorticoids, insulin-like growth factor-I, and prolactin have clinically significant effects on specific aspects of hair growth. The nuclear receptors vitamin D receptor and retinoid X receptor are essential for postnatal hair cycling. Other hormones have less clear effects on hair growth. Advances in research on the interaction of hormone target genes with the biological processes involved in hair morphogenesis and cycling can be expected to improve management of hirsutism and alopecia.

 

[waynakyo]

Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression - PMC

The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects in mammals and is also found in extrapituitary sites, including murine skin. Here, we show by reverse transcriptase-polymerase chain reaction and ...

www.ncbi.nlm.nih.gov

 

[Dr sanches]

Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression - PMC

The prototypic pituitary hormone prolactin (PRL) exerts a wide variety of bioregulatory effects in mammals and is also found in extrapituitary sites, including murine skin. Here, we show by reverse transcriptase-polymerase chain reaction and ...

www.ncbi.nlm.nih.gov

 

[Armando Jose]

deaths ? Have you more info?

 

[Kagaho]

deaths ? Have you more info?

Its from a good source Armando. Sanches is one of the principal investigators of the study. We are so lucky to have him on the forum.

 

[Jackshtbro]

deaths ? Have you more info?

I believe all of the participants died but they only recruited 20 patients so could've just been placebo/coincidence. They will run a trial with more patients to make sure

 

[Dr sanches]

deaths ? Have you more info?

“ during our phase 2 trials we have gone through obstacles figuring out 20 deaths of clinical patients with our heavily studied androgenetic alopecia topical drug pyrilutamide”

 

[RolfLeeBuckler]

So it is over now with Phase II trials of HMI-115 this year ?

 

[Jackshtbro]

So it is over now with Phase II trials of HMI-115 this year ?

Yes Rolf, it's over

 

[RolfLeeBuckler]

Yes Rolf, it's over

Then we Can close this Thread until 2023

 

[ppma]

If this works close to a cure then every pharmaceutical company under the sun will be researching the prolactin pathway for alternative angles to attack, we'll eventually get a cheap treatment, but it might take 10 years..

So much agree on this. The real value of HMI115 is proving that attacking the PRLR is an effective way of dealing with Androgenetic Alopecia, setting new basis for further research.

The fact that we are in this forum creates a biased illussion that all the balding guys out there are desperate, but this forum only represents a ridiculous amount of people willing to put experimental drugs in their bodies without due controls or spend obscene amounts in a treatment to get their hair back. Most bald men do not give a f*** about their condition and will not even think about a solution if it involves spending $10k/year.

The market is huge, but only if the results are proven and the treatment is affordable (which does not mean cheap).

 

[Feramon1]

So much agree on this. The real value of HMI115 is proving that attacking the PRLR is an effective way of dealing with Androgenetic Alopecia, setting new basis for further research.

The fact that we are in this forum creates a biased illussion that all the balding guys out there are desperate, but this forum only represents a ridiculous amount of people willing to put experimental drugs in their bodies without due controls or spend obscene amounts in a treatment to get their hair back. Most bald men do not give a f*** about their condition and will not even think about a solution if it involves spending $10k/year.

The market is huge, but only if the results are proven and the treatment is affordable (which does not mean cheap).

Exactly. I think this topic is also promising in terms of discussing possible options for influencing prolactin.

 

[badnewsbearer]

This proves monkey studies don’t mean sh*t and hope medicine is a joke

i dont understand why this degenerate is not banned

 

[pegasus2]

So much agree on this. The real value of HMI115 is proving that attacking the PRLR is an effective way of dealing with Androgenetic Alopecia, setting new basis for further research.

The fact that we are in this forum creates a biased illussion that all the balding guys out there are desperate, but this forum only represents a ridiculous amount of people willing to put experimental drugs in their bodies without due controls or spend obscene amounts in a treatment to get their hair back. Most bald men do not give a f*** about their condition and will not even think about a solution if it involves spending $10k/year.

The market is huge, but only if the results are proven and the treatment is affordable (which does not mean cheap).

First they have to develop it and do preclinical testing. 10 years is optimistic. By the time another treatment was on the market HMI's patent would be close to expiration. At that time there will be some company out there selling generic mAbs at a deep discount.