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That is true, it would be pointless to have women in the hair trial since they're doing a women-only endometriosis phase 2 trial and can glean hair info from that.
HMI-115 PRLR antibody: The Most Promising Treatment Ever
- Thread starter pegasus2
- Start date
- Reaction score
- 479
He's not lying, he's simply dumb. There are hundreds of people on this very forum that have taken every experimental drug under the sun and they look in the mirror within a week of taking it and are convinced that they see new hairs sprouting, which obviously is physiologically impossible.
There are so many factors that contribute to this phenomenon, but there's no malice. It's simply delusion and a lack of critical thinking skills.
Hairismylife
Established Member
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- 77
He did have regrowth, if you think otherwise you are delusional.
In macaques the men responded much better than the females
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Okay fine I'll admit that he went from roughly norwood 6 to about norwood 6.
Unless you're referring to the pictures where he went from norwood 6 to norwood 3? The ones where his entire head is very clearly painted with fibers? Which he admitted to using? If you count fibers then yea he got a ton of regrowth. If you don't count fibers then he got no regrowth.
According to the investigators he was NW4 to begin with, and went to NW3. Lay people always exaggerate norwoods.
By the way, did you see that pyrilutamide failed? Kevin Mann said it would be the cure
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His 2023 photos seem like norwood 6 to me, but I do see a lot of differences in norwood scales across the internet. On some he's norwood 4 and on others he's norwood 6.
On this he's definitely norwood 6. It's possible they judged him as 4A on this scale, but to me his hair is nowhere near dense enough to warrant that. Either way he's Norwood 6 as late as June 2023.
I also did not see that pyrilutamide failed. I wasn't following it closely, but I do recall that there was a particularly... eccentric person on this forum that was using it and he was convinced it worked amazing for hair, but also that somehow his dick stopped working within 24 hours of taking it. So it was hard for me to take it seriously.
But yeah that's really unfortunate. Because that was one of the bigger names of potential future treatments. Top 3 even.
The Norwoods are just a visual description. IMO it would be more useful if people described it with stages. "He's a current NW3 with visible Norwood#6 thinning."
As for Pyrilutamide?
It's an androgen-fighting method. We already know the limits of that whole general approach. If chemical castration doesn't even regrow much lost hair, then it's pointless to hope for more results than that from less severe drugs.
Blocking/reducing androgens is only good for slowing down future hair loss. Period. Whatever regrowth it generates is a mild rebound effect in follicles that went bald more recently so they were still hanging by a thread.
As for Pyrilutamide?
It's an androgen-fighting method. We already know the limits of that whole general approach. If chemical castration doesn't even regrow much lost hair, then it's pointless to hope for more results than that from less severe drugs.
Blocking/reducing androgens is only good for slowing down future hair loss. Period. Whatever regrowth it generates is a mild rebound effect in follicles that went bald more recently so they were still hanging by a thread.
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Hola, no vi ese estudio. ¿Puedes pasarme el enlace donde lo viste?
Pyrilutamide finished stage II trials in US with +10hair/cm and started and completed subject enrolment in phase III in China.
Are you talking in terms of pyralitamide being/not being a miracle drug?
"pyralitamide failed" for me means it can not block DHT receptors at all/sides overweight the effect.
These are the phase 2 results that Kintor shared for Pyrilutamide:
Placebo BID was around 7 TAHC cm2
5mg BID was around 22 TAHC cm2
22 - 7 = 15 TAHC cm2 when comparing change versus placebo at 6 months.
What would be more interesting in my opinion is to know whether Pyrilutamide looses efficacy after 6 months similar to clascoterone (CB-03-01).
Once the phase 3 results are out, which should be any day now that should tell us more but for now I'd suggest sticking to RU.
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Acaba de salir una declaración de Kintor sobre la fase 3... y sí, falló.
They have just came out with a press release on this (phase 3) , check out the new thread in the research section
No, their Phase III was announced already. It didn't meet statistical significance. They will have to redo it with a longer duration and higher N, or abandon the drug. It just isn't very good.
開拓藥業重挫逾35%！KX-826 III期臨牀試驗頂線數據公佈
分析結果顯示，與安慰劑相比，KX-826組TAHC在各個訪視點均有提高，差異在統計學上未達到顯着性>>11月27日，開拓藥業-B(09939)早盤低開，截至發稿...
news.hstong.com
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I have always been cautious, but I must rule out Kintor. In his latest statement they have issued a warning about investing in his company. Therefore that means that we do not expect anything.
I think HMI is going the same way.
good luck to everyone.
I think HMI is going the same way.
good luck to everyone.
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- 479
Given Hope's eagerness to partner with a manufacturing company for commercialization, it looks like they're planning on shipping it out regardless of its results in humans. They already have amazing marketing material with the stump-tailed macaque trial alone. Minoxidil also had a stump-tailed macaque trial show positive results the same year it came to market in 1986, so they have an easy minoxidil comparison too. That's really all you need to successfully sell a hair loss product. Plenty of cosmetic hair loss products that have been proven to do nothing still fly off the shelves because of good marketing. As far as drugs, it has much a better marketing profile than PRP and somehow PRP is still thriving in dermatologists' treatment repertoire. Which I'd argue is only because those useless and clueless mfers get off on the $ervice charge of the injections. Which funnily enough would also apply to HMI-115. So I'd put money on it releasing, effective or not.
Baldness is truly an ineradicable curse. Now we are able to do more or less anything, but baldness remains unbeatable. No one has ever undertaken to connect the dots, try to intertwine all the possible paths and trace back to a possible path to hit with all the forces. it's really "amazing", it seems that so many genes and pathways regulate something as simple as hair in humans. HMI seemed promising thanks to the experiments on macaques but apparently it will be yet another bullshit, and this for three generations. I hope that this reddit user is a liar, or a placebo... if this were not to be the case it would mean that this thing is literally incurable, either due to the complexity, or due to the absolute incompetence of the scientists, lack of real will.
As usual we find ourselves counting the hairs, which are now even higher in number than the disappointments. For goodness sake I have nothing to say, in fact I respect the reckless and the people who are constant in their treatment. Unfortunately, I'm not like that, all or nothing. And apparently we should resign ourselves again.
ps: the last possibility is that the treatment is still at very low doses or that it requires even more time, we are really waiting for the results even if all this waiting doesn't give me hope in any case. What an endless odyssey.
As usual we find ourselves counting the hairs, which are now even higher in number than the disappointments. For goodness sake I have nothing to say, in fact I respect the reckless and the people who are constant in their treatment. Unfortunately, I'm not like that, all or nothing. And apparently we should resign ourselves again.
ps: the last possibility is that the treatment is still at very low doses or that it requires even more time, we are really waiting for the results even if all this waiting doesn't give me hope in any case. What an endless odyssey.
It amazes me how people are already claiming this is another BS even without the results having been released.
They've gone towards making partnerships for commercialization already. This won't be a cheap topical, it's a synthetic antibody that will cost 1000s of dollars. Going mass production without solid background that it works is a suicide.
Moreover, the most interesting thing is to prove that the PRLR is one of the main mediators. Supposed this premise is proven true, this opens up new research that will have much better odds to yield reliable treatments than the current approaches.
They've gone towards making partnerships for commercialization already. This won't be a cheap topical, it's a synthetic antibody that will cost 1000s of dollars. Going mass production without solid background that it works is a suicide.
Moreover, the most interesting thing is to prove that the PRLR is one of the main mediators. Supposed this premise is proven true, this opens up new research that will have much better odds to yield reliable treatments than the current approaches.