'Holy Grail' Prescription Formula - Input Welcome from HairLossTalk!

Blackjack17u4

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Finasteride 0.01% (microdosed to prevent systemic absorption, as we've documented 71% suppressed serum DHT using a stronger 0.25% topical, equivalent to the suppression seen with 1mg oral finasteride).
I know the study you are referring to, but I think the systemic effects highly depend on the vehicle used. There is another study showing that 0.25% topical finasteride does not affect serum dht.

A randomized, double-blind controlled study of the efficacy and safety of topical solution of 0.25% finasteride admixed with 3% minoxidil versus 3% minoxidil solution in the treatment of male androgenetic alopecia. doi:10.1111/jdv.15171

I am currently looking for a reasonable topical finasteride solution that would not significantly suppress my DHT levels and still provides decent hair protection.
 

Dr.

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- Cetirizine has a molecular weight of 388, and Desloratadine 311, so according to the 500 Dalton rule, they have the possibility of being absorbed past the corneal layer. Probably going to skip these unless people really want it and are willing to risk systemic absorption.
- Duasteride's molecular weight is 528, so is less likely to go systemic, but I recall people here tried it and still had side effects? If anyone has the relevant posts, I'd like to read through them.
- Can't legally do CB or RU or other non-FDA approved drugs or non-GRAS supplements.
- I will see if we can avoid proplyene glycol as the carrier, thanks for the reminder.
- This is going to be US distribution only for now, since it will be US doctor prescribed.
- I've personally tested finasteride 0.25% and it suppressed systemic DHT levels on bloodwork just as much as 1mg oral finasteride. Definitely a no go.
- Someone pointed out that Ketoconazole may be absorbed systemically over time, which is why its better as a shampoo.

- I'm figuring out cost once we have the final formula. I'm trying to keep it under $99/mo to make it accessible. Latanoprost at 0.1% is very pricey, which is why it's not available anywhere at the correct dosage used in the studies. What is your willingness to pay if it had most of these ingredients? $99? $149? $199?
 

Pls_NW-1

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- Cetirizine has a molecular weight of 388, and Desloratadine 311, so according to the 500 Dalton rule, they have the possibility of being absorbed past the corneal layer. Probably going to skip these unless people really want it and are willing to risk systemic absorption.
- Can't legally do CB or RU or other non-FDA approved drugs or non-GRAS supplements.
- I will see if we can avoid proplyene glycol as the carrier, thanks for the reminder.
- This is going to be US distribution only for now, since it will be US doctor prescribed.
- I'm figuring out cost once we have the final formula. I'm trying to keep it under $99/mo to make it accessible. Latanoprost at 0.1% is very pricey, which is why it's not available anywhere at the correct dosage used in the studies. What is your willingness to pay if it had most of these ingredients? $99? $149? $199?
What about Darolutamide... its approved for other indications and its half-life is "okay" when you consider the potency of it.
 

TurboFixer

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- Cetirizine has a molecular weight of 388, and Desloratadine 311, so according to the 500 Dalton rule, they have the possibility of being absorbed past the corneal layer. Probably going to skip these unless people really want it and are willing to risk systemic absorption.
- Can't legally do CB or RU or other non-FDA approved drugs or non-GRAS supplements.
- I will see if we can avoid proplyene glycol as the carrier, thanks for the reminder.
- This is going to be US distribution only for now, since it will be US doctor prescribed.
- I'm figuring out cost once we have the final formula. I'm trying to keep it under $99/mo to make it accessible. Latanoprost at 0.1% is very pricey, which is why it's not available anywhere at the correct dosage used in the studies. What is your willingness to pay if it had most of these ingredients? $99? $149? $199?
The compound in CB (clascoterone) is actually fda approved as an acne medication under the brand name Winlevi. It is 1% clascoterone instead of the 7% which will be used for hair, however
 

Dr.

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- Thanks for the tip on Darolutamide. Anecdotally, seems to have some anti-androgenic side effects, which is concerning: https://www.hairlosstalk.com/intera...lutamide-today-update-every-two-weeks.110253/
- Thanks for the heads up on CB (clascoterone)'s recent FDA approval. Is 7% the only concentration that has been shown to work in hair loss? I recall it's pretty pricey, so that may be more of a dealbreaker than anything, since we have to source it from FDA-approved manufacturers, not cheap Chinese labs that have adulterated products.
 

Dr.

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Updated formulation, appreciate feedback. We can only use OTC ingredients from this FDA-approved list, so had to simplify a bit. Latanoprost at the 0.1% used in the original studies is very expensive, so the following formulation would probably have to be $149/month. We could get it down to $99/month if we cut the Latanoprost down to maybe 0.06%. Do people have a strong preference either way?

  • Rx Ingredients:
  1. Latanoprost 0.1%
  2. Minoxidil 8%
  3. Tretinoin 0.01%
  • OTC Ingredients:
  1. Melatonin 0.0033%
  2. Azelaic Acid 5%
  3. Zinc Sulfate 0.25%
  4. Vitamin B6 (P5P) 0.25%
 

Selb

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Updated formulation, appreciate feedback. We can only use OTC ingredients from this FDA-approved list, so had to simplify a bit. Latanoprost at the 0.1% used in the original studies is very expensive, so the following formulation would probably have to be $149/month. We could get it down to $99/month if we cut the Latanoprost down to maybe 0.06%. Do people have a strong preference either way?

  • Rx Ingredients:
  1. Latanoprost 0.1%
  2. Minoxidil 8%
  3. Tretinoin 0.01%
  • OTC Ingredients:
  1. Melatonin 0.0033%
  2. Azelaic Acid 5%
  3. Zinc Sulfate 0.25%
  4. Vitamin B6 (P5P) 0.25%
I would offer a non tretinoin version too. It’s not exactly something everyone wants to try
 

Dr.

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I would offer a non tretinoin version too. It’s not exactly something everyone wants to try
We're trying not to have multiple versions right now to keep things simple. What's the downside with tretinoin at 0.01%?
 

Dr.

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Thanks for all your input, excited to announce the launch of the Maximus Warrior Protocol!

It is a non-greasy topical gel/cream that's applied 1mL a day, along with microneedling once a week (it comes with a unique flat titanium dermastamp as well to enhance absorption & growth factors). It's not cheap at $149-$199/month, but it has the clinically-effective strengths of latanoprost being used in clinical trials, so is worth the cost if you want what celebrities are using and cost isn't an issue for you (or if it saves you a hair transplant down the line, that's pretty good ROI). Here are the ingredients:

Latanoprost 0.03-0.1% (Rx)
Minoxidil - 8% (Rx)
Tretinoin - 0.01% (Rx)
Melatonin - 0.0033%
Azelaic Acid - 5%
Zinc-Thymulin - 0.001%
Vitamin B6 (P5P) - 0.25%
Sandalore - 0.1%
Methyl Vanillate - 0.2%

Feedback Welcome:
Appreciate any feedback on the formula from the HairLossTalk community, as we can adjust this over time. We may be able to eventually get the cost down (a little bit) over time by just sticking to the 3 Rx ingredients above with a 3-month commitment.

Requests for Future Treatments:
Finally, let me know if there's anything that you'd like to see offered (must be FDA-approved medications that can be legally prescribed). For example, we're looking offering into a combined sublingual minoxidil/oral dutasteride option for those who don't mind systemic treatment and want DHT blockage. If people have preferred dosages they want to see with that oral treatment, let me know and I can pass that feedback along to our clinical team as well.

Buy Here:
https://bit.ly/3VdJg92

References:
maximustribe.com/warrior/#reference
 
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Mustang

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That's a lot of money for a growth stimulant, latanoprost is indeed expensive but it won't do anything Minoxidil doesn't. Specially orally.

Alpha is the same price, albeit it does "disrupt" hormones, however it's very dose sensible and proven to reverse hair loss.

 
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