Hormone Replacement Therapy Reverted My Androgenetic Alopecia

DHTpolice

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Ok, thanks for the information. I will try 2 mg of Progynova for the first year, and then maybe switch to 4 mg daily. I don't mind to have brests if it helps me with hair regrowth. I consider it as a trade-off. Also I hate male's second sexual characteristics, they do not suit me at all, only making me uglier and older. When beard started appearing at 18, I was constantly thinking how to prevent it from further developing, but, unfortunately, I knew nothing about androgen deprivation and estrogen therapy at that time. Hair loss didn't bother me then, and I was satisfied with my look after shaving the beard, so I ended my research pretty quickly. But hair loss affected me very badly and rapidly to do nothing with it. I was in denial for 6 months, thought I was vitamin deficient and ill, cause hair loss is not common in family (father is Norwood 1 at 52 with great density, mother is thinner at 48, but probably due to the estrogen decline and her antihypertensive drugs). Fortunately, I came across this site, and learned about 5α-Reductase inhibitors. Strangely enough, but I immediately realized how weak they are. After reading well-known Hamilton's study I chose chemical castration as the most effective and reliable option for treating this desease. Conventional treatment (big 3) is not for me, cause I can't stand the look of mature hairline, even if it Norwood 2.

I am on finasteride and spironolactone since the beginning of this year, added low dose cypro a bit later. Never checked my hormonal profile, but I suppose my T is low, but not in female range yet, cause my receptors are still under the significant androgen stimulation (itch and oiliness are not gone completely). Brain detects a low level of testosterone and produce LH, which, in turn, sends signal to testicles to produce even more T. I hope, 2 mg of E will be enough to achieve estrogen dominance and brain will stop that cascade of processes. Time will tell.

P. S. Да, в России и Украине в продаже доступен только эстрадиола валерат (Progynova). Я в курсе, что его следует принимать перорально, но спасибо за предупреждение. Всё же я бы предпочёл Estrofem, он гораздо эффективнее усваивается и имеет более выраженный эффект. Возможно, я буду заказывать Estrofem с AllDayChemist, когда мой доход немножко стабилизируется. Но пока что в плане экономии и доступности Progynova более рациональный выбор для меня.
 
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ManinBlack

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Ok, thanks for the information. I will try 2 mg of Progynova for the first year, and then maybe switch to 4 mg daily. I don't mind to have brests if it helps me with hair regrowth. I consider it as a trade-off. Also I hate male's second sexual characteristics, they do not suit me at all, only making me uglier and older. When beard started appearing at 18, I was constantly thinking how to prevent it from further developing, but, unfortunately, I knew nothing about androgen deprivation and estrogen therapy at that time. Hair loss didn't bother me then, and I was satisfied with my look after shaving the beard, so I ended my research pretty quickly. But hair loss affected me very badly and rapidly to do nothing with it. I was in denial for 6 months, thought I was vitamin deficient and ill, cause hair loss is not common in family (father is Norwood 1 at 52 with great density, mother is thinner at 48, but probably due to the estrogen decline and her antihypertensive drugs). Fortunately, I came across this site, and learned about 5α-Reductase inhibitors. Strangely enough, but I immediately realized how weak they are. After reading well-known Hamilton's study I chose chemical castration as the most effective and reliable option for treating this desease. Conventional treatment (big 3) is not for me, cause I can't stand the look of mature hairline, even if it Norwood 2.

I am on finasteride and spironolactone since the beginning of this year, added low dose cypro a bit later. Never checked my hormonal profile, but I suppose my T is low, but not in female range yet, cause my receptors are still under the significant androgen stimulation (itch and oiliness are not gone completely). Brain detects a low level of testosterone and produce LH, which, in turn, sends signal to testicles to produce even more T. I hope, 2 mg of E will be enough to achieve estrogen dominance and brain will stop that cascade of processes. Time will tell.

P. S. Да, в России и Украине в продаже доступен только эстрадиола валерат (Progynova). Я в курсе, что его следует принимать перорально, но спасибо за предупреждение. Всё же я бы предпочёл Estrofem, он гораздо эффективнее усваивается и имеет более выраженный эффект. Возможно, я буду заказывать Estrofem с AllDayChemist, когда мой доход немножко стабилизируется. Но пока что в плане экономии и доступности Progynova более рациональный выбор для меня.

Have you considered getting your entire beard transplanted to your head as opposed to electrolysis? There are some hair transplant surgeons that do beard transplants. Might as well kill 2 birds with one stone.
 

DHTpolice

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Have you considered getting your entire beard transplanted to your head as opposed to electrolysis? There are some hair transplant surgeons that do beard transplants. Might as well kill 2 birds with one stone.
Yes, it would be a great idea (only if the hair from beard will look similiar with the head's hair), but I prefer to consider hairline feminization surgery instead of traditional hair transplant and only as a last resort. Estrogen and antiandrogens should take care of thinning all over. Ok, will not hijack the thread.
 

yourworld001

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Yes, it would be a great idea (only if the hair from beard will look similiar with the head's hair), but I prefer to consider hairline feminization surgery instead of traditional hair transplant and only as a last resort. Estrogen and antiandrogens should take care of thinning all over. Ok, will not hijack the thread.

Are you transgender? want you become a women?
 

yourworld001

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You're definitely not cis.


It was 1998 when I was 18 and sadly the only trans person that I knew of was the Israeli singer Sharon Cohen (Dana International) and I didn't have any idea how she managed to have such a feminine body and face :)


5AR-inhibitors tend to work for some and not for others. And their safety profile is questionable, not that CPA or spironolactone have a better safety profile. Chemical castration on the other hand is not a long term option, because you risk to have your liver or kidneys damaged. With some trans people 6mg of sublingual estradiol seems to be enough to cause negative feedback on the HPG axis once the E2 levels are in female ranges. But starting with 2mg and not increasing the dose until a few months had passed will promote normal breast development (if it matters to you).


While finasteride and low doses of spironolactone do not induce negative feedback in HPG axis, cypro does so. I don't know what's your dosage of cypro, but 50mg alone will most probably knock down your T production in a matter of 3 weeks, then you could lower the dose and add E2 and your T will still not increase. I've been on spironolactone+cypro together for 1 month while removing spironolactone from my regimen. I haven't made any blood work since April.

Why you disliking questions I ask, they are genuine.
 

DHTpolice

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You're definitely not cis.


It was 1998 when I was 18 and sadly the only trans person that I knew of was the Israeli singer Sharon Cohen (Dana International) and I didn't have any idea how she managed to have such a feminine body and face :)


5AR-inhibitors tend to work for some and not for others. And their safety profile is questionable, not that CPA or spironolactone have a better safety profile. Chemical castration on the other hand is not a long term option, because you risk to have your liver or kidneys damaged. With some trans people 6mg of sublingual estradiol seems to be enough to cause negative feedback on the HPG axis once the E2 levels are in female ranges. But starting with 2mg and not increasing the dose until a few months had passed will promote normal breast development (if it matters to you).


While finasteride and low doses of spironolactone do not induce negative feedback in HPG axis, cypro does so. I don't know what's your dosage of cypro, but 50mg alone will most probably knock down your T production in a matter of 3 weeks, then you could lower the dose and add E2 and your T will still not increase. I've been on spironolactone+cypro together for 1 month while removing spironolactone from my regimen. I haven't made any blood work since April.

Most probably I am not cis, but at the moment I will try to stay androgynous as long as possible, because I am living with parents, and they are ultra-conservative. I don't fear them at all, I even recently told them I am a non-binary transgender to get their reaction, they are laughed at me, that's it. But full blown transition to female is currently not an option for me, even despite the fact I would pass as a female without too much work.

I know, chemical castration drugs for long-term use is not good for health. Nevertheless, on eunuchs.org there are many cases of those who are living with undetectable T for decades without E and still not experiencing any health issues. I am taking 12.5 mg of cypro eod since March, now taking that dose every day.
 

folfoxorack

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@chillvisio : I don't know if you have the answer, but who knows.What do you thing about taking 12.5 mg of cypro every 3 days. It will lower testosterone ? Not at all ? Too much ? An idea ?
Thanks
 

folfoxorack

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Hm Ok ... I will test it, and it's not enough I will increase the dosage gradually. Thanks for your input.
 

dustovshio

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Hi @DHTpolice.
The reason was sort of personal. I've seen my granny dying as a result of kidney failure with creatinine 660 and uremia. She had only one kidney functioning since 2014 and that made me very sad and afraid of using meds messing with my kidneys (all diuretics do so). So I decided to swap spironolactone which was suppressing my T great at that of a low dose with Cypro at low dose (dosages of 25mg and higher are considered high dosage of CPA and have risk of inducing pituitary tumors). For me 12.5mg of Cypro look like a more acceptable risk than any diuretic acting as T blocker.
So, this was the reason behind that change. I'm doing my best to change my documents and have my testes removed before my liver dies because of Cypro
So what do you think about bicalutamide? I thought it was supposed to be safer than CPA.
 

folfoxorack

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I don't think Bicalutamide is a good choice for hair loss and I'm sorry to conclude that ... First it increase testosterone, so DHT as well. Second, it's not as strong as Dutasteride to protect our precious follicles against DHT. I tried 12.5mg, 25, 50 and 100mg of Bicalutamide and itchy scalp was insane, because at the same time I lowered Dutasteride, and Bicalutamide couldn't replace it. As soon as I took back Dutasteride this f@*%£ing itchy scalp ... was gone, and my libido with it, unfortunately.
Bicalutamide is good against Testosterone, not strong enough against DHT, at average dose.
I tried Cyproterone with Bica (12.5mg, 25mg and 50) ... my balls shrank a lot, a lot more than with 100 spironolactone actually. And they are still pretty small with 12.5mg every other day now ... it's pretty strong. But still not enough against DHT ...
I think Cypro+Bica should be avoided. If Finasteride doesnt help, go to Dutasteride 0.5mg, if it's not enough, try something like 3 pills every 3 days ... Yeah from my experience is not like 1 pill a day. It doesn't really make sense, but it works like that. I have quicky itchy scalp when my DHT is coming back stronger, so I always know when I have to lower it to protect my hair. When I take duta, after a day itchy scalp disappears.
And if you're trans mtf on treatment and still losing your hair ... take dutasteride, a lot of trans do that, even if they have almost no testosterone. Dutasteride will protect your hair, and Estradiol will your hair grow.
 

bridgeburn

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I don't think Bicalutamide is a good choice for hair loss and I'm sorry to conclude that ... First it increase testosterone, so DHT as well. Second, it's not as strong as Dutasteride to protect our precious follicles against DHT. I tried 12.5mg, 25, 50 and 100mg of Bicalutamide and itchy scalp was insane, because at the same time I lowered Dutasteride, and Bicalutamide couldn't replace it. As soon as I took back Dutasteride this f@*%£ing itchy scalp ... was gone, and my libido with it, unfortunately.
Bicalutamide is good against Testosterone, not strong enough against DHT, at average dose.
I tried Cyproterone with Bica (12.5mg, 25mg and 50) ... my balls shrank a lot, a lot more than with 100 spironolactone actually. And they are still pretty small with 12.5mg every other day now ... it's pretty strong. But still not enough against DHT ...
I think Cypro+Bica should be avoided. If Finasteride doesnt help, go to Dutasteride 0.5mg, if it's not enough, try something like 3 pills every 3 days ... Yeah from my experience is not like 1 pill a day. It doesn't really make sense, but it works like that. I have quicky itchy scalp when my DHT is coming back stronger, so I always know when I have to lower it to protect my hair. When I take duta, after a day itchy scalp disappears.
And if you're trans mtf on treatment and still losing your hair ... take dutasteride, a lot of trans do that, even if they have almost no testosterone. Dutasteride will protect your hair, and Estradiol will your hair grow.
If Bica blocks androgen receptors then it should protect against DHT effects, but it doesn't sound like it was doing a good job at that.
 

folfoxorack

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If Bica blocks androgen receptors then it should protect against DHT effects, but it doesn't sound like it was doing a good job at that.

That's what I thought ... But with "only" 0.5-1mg dutasteride + 25-50mg Bicalutamide + 25mg Cyproterone my itchy scalp came back ... When I returned to Dutasteride at 1-2mg ...this itchy scalp disappeared ...
As I said some of trans MTF still take Finasteride or even Dutasteride with Cyproterone/Estradiol treatment. Because without anti-DHT hair loss is not cured, even with very low Testosterone.
 

bridgeburn

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That's what I thought ... But with "only" 0.5-1mg dutasteride + 25-50mg Bicalutamide + 25mg Cyproterone my itchy scalp came back ... When I returned to Dutasteride at 1-2mg ...this itchy scalp disappeared ...
As I said some of trans MTF still take Finasteride or even Dutasteride with Cyproterone/Estradiol treatment. Because without anti-DHT hair loss is not cured, even with very low Testosterone.
maybe your body was resisting the medication. I heard some get hornier at first after starting cypro but then it goes away. I agree anti-DHT is important cause if even a little bit of testosterone turns to Dht, then it becomes at least 10x stronger. and does itching always mean hairloss?
 

folfoxorack

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With Cypro my balls shrank a lot ... it works well.
Yeah Itchy scalp means hair loss, at least for me.
 

dustovshio

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Bicalutamide has hepatotoxicity as side effect as well. If you're a cisgender man, it's the best choice, because it does not block androgen receptors in the brain, so neurological and psychological effects of T will still be there, but if you're a trans person the psychological effects of testosterone might not be well tolerated in the presence of high enough (male range) T levels.


No, I didn't notice anything like that. But some people taking spironolactone report muscle cramps in the legs which might be due to electrolite imbalance (Potassium/Sodium). Other reason for muscle pain might be muscle loss due to androgen deprivation.
Thanks for your response I was taking spironolactone at one time in conjunction with cpa (diane35) and started getting some muscle weakness. I thought the cpa was suspect, but in retrospect I think maybe the spironolactone was the cause of general muscle atrophy low libido etc.
 

dustovshio

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CPA and bicalutamide have both possible liver damage and elevated liver enzymes as side effects, so taking them together synergistically increases the risk.
DHT blocker is a good choice for those who still have their T not in female range. Once on E2 and having T suppresded, DHT will be in female ranges as well and as we know women don't have Androgenetic Alopecia unless they have PCOS which means their T will be above female range.
DHT blockers don't help in stimulating hair growth. It's E2 and also minoxidil which be of some help.
So how did you come to the conclusion that E2 can stimulate hair growth.
 

dustovshio

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Antydht wasn't on estradiol only cpa and he regrew but that's not surprising since cpa causes massive hair growth when taken orally. Not sure if I agree with the part about estradiol not effecting your dick until you stop it though. Seems like it immediately starts to fubar it.
 

folfoxorack

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CPA and bicalutamide have both possible liver damage and elevated liver enzymes as side effects, so taking them together synergistically increases the risk.
DHT blocker is a good choice for those who still have their T not in female range. Once on E2 and having T suppresded, DHT will be in female ranges as well and as we know women don't have Androgenetic Alopecia unless they have PCOS which means their T will be above female range.
DHT blockers don't help in stimulating hair growth. It's E2 and also minoxidil which be of some help.

What I wanted to say is :
A lot of guys are thinking about taking Anti Androgens like Cyproterone, or Bicalutamide, or even Estradiol. They think it's the best choice.
I say : No.
They just have to nuke DHT level. With Dutasteride.
It's not because you lower your testosterone level that your hair will be saved. I'm sure of that now. Even if you lower your testosterone levels to female ranges. Even women, with female testosterone range, lose their hair. That's what I learnt from trans MTF actually. I'm disappointed, because I really thought it will cure my hair loss ...
If you have a very agressive hair loss, don't take Testosterone blockers, just take Dutasteride at high dose, and it will work. And you won't have boobs. But it may kill your libido like it does with me. (And Cyproterone + Bicalutamide + Low dose Dutasteride = high libido).
 
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