How can dutasteride not work?

[TransientHair]

Does anyone have a link to a well documented story of someone losing ground on legit Dutasteride?

 

[xRedStaRx]

I love seeing how DHT levels are somehow correlated with hair loss, when it's most likely the opposite.

 

[abcdefg]

Whether DHT is the initial trigger or not in a longer series of event does it really matter if we are trying to prevent male pattern baldness than stopping androgens is still the goal regardless. I would be curious to see though that for sure its just DHT and not T at all. Why DHT and not other forms of androgens? The androgens interact with receptors so why would T do nothing? although its always been more sensitivity to androgens but we dont know how that works.

 

[Ventures]

Androgens aren't the problem!
Inhibiting DHT disrupts the biological male pattern baldness pathway, but it's not what actually causes hair to miniaturize, but it's an important step to reach that phase.
This is why testosterone does not cause male pattern baldness, if anything, testosterone is GOOD for hair. It's DHT itself that's the problem.

What exactly causes MBP to you ? PGD2 or other enzyme elevated in balding areas ? Can you explain downstream effects after binding DHT to AR ?

Men like Obama, or Mandela who have thick hair all their life have very low level of growth inhibitors in scalp and follicles as opposite to us who have increased levels of thic enzymes which cause alopecia.

I love seeing how DHT levels are somehow correlated with hair loss, when it's most likely the opposite.

By that you mean; usually people are confused with local scalp DHT levels and systemic DHT levels - which aren't the same. So, someone with low serum DHT can have very high scalp and follicular DHT ?

 

[xRedStaRx]

What exactly causes MBP to you ? PGD2 or other enzyme elevated in balding areas ? Can you explain downstream effects after binding DHT to AR ?

Men like Obama, or Mandela who have thick hair all their life have very low level of growth inhibitors in scalp and follicles as opposite to us who have increased levels of thic enzymes which cause alopecia.

This is too complicated to write out, no one understands how it exactly works, but a lot of theories are out there.

Check this thread out if you want a lot to chew on: http://www.hairlosshelp.com/forums/messageview.cfm?catid=7&threadid=114197&enterthread=y<br />

What we know for sure in simple terms is that DHT is a huge factor in the cascade process that leads to male pattern baldness at the end of the stream. Stopping DHT production inside the follicles disrupts the process and your hair gets to see another day. HOWEVER, it does not regrow back miniaturized hair, which leads one to believe that it is simply a catalyst in the process, and not the convict.

By that you mean; usually people are confused with local scalp DHT levels and systemic DHT levels - which aren't the same. So, someone with low serum DHT can have very high scalp and follicular DHT ?

Exactly, usually high serum levels of DHT indicate the opposite at the tissue levels, else you won't find any leakage in the bloodstream. There was a study AFAIR that showed an inverse correlation between male pattern baldness and serum DHT levels.

 

[RoyD]

Well I am losing hair on dutasteride for over a year now. Either I'm a totally unlucky bastard or my meds are ****ing fake! I really need to do a blood test to check my DHT levels.

 

[abcdefg]

Or your hair is sensitive to the higher T levels you have since T is also an androgen. Men injected with T go bald although Im not sure the study isolated it was from the resulting DHT or just the T.

 

[Ventures]

Or your hair is sensitive to the higher T levels you have since T is also an androgen. Men injected with T go bald although Im not sure the study isolated it was from the resulting DHT or just the T.

No that would make no sense. Even Bryan agreed that increase in T level can't compensate significant reduction of DHT in scalp due to use of dutasteride. You hair always benefits from using finasteride and dutasteride, unfortunately other parts of your body don't.

RoyD I think. That every hair loss sufferer even those with aggressive male pattern baldness should start with finasteride 0.5 mg; 1mg od 1.25mg. And then wait at least one, one and a half year to evaluate situation. Hair growth cycles are pretty long in time duration and you can't see improvement immediately. It is important to be patient and don't expect results to happen in next month, because thickening of hair shaft is long process. And don't forget that you first experience shedding which is common effect in finasteride and dutasteride therapy. Maybe you are confusing your current hair loss situation with shedding which means that old, weak hair is lost and eliminated by new healthy hair.

I hope this helps a little.

 

[RoyD]

@Ventures Bro ... I began finasteride in min 2013 and was on it for 6 months with not even 1% of improvement until I panicked and jumped to dutasteride in Dec 2013. Basically it's been more than a year since I've been on dutasteride and I've only lost more and more hair. It's almost gona be 2 years now that I've been on anti androgens. My hairloss is like if Hulk were given Ironman's suit and Thor's hammer with Superman's powers and asked to destroy my hair follicles to the absolute best of its ability. My hair loss probably wouldn't stop even if I castrated myself.

- - - Updated - - -

ok I do not know how to tag :/

 

[vee7]

@Ventures Bro ... I began finasteride in min 2013 and was on it for 6 months with not even 1% of improvement until I panicked and jumped to dutasteride in Dec 2013. Basically it's been more than a year since I've been on dutasteride and I've only lost more and more hair. It's almost gona be 2 years now that I've been on anti androgens. My hairloss is like if Hulk were given Ironman's suit and Thor's hammer with Superman's powers and asked to destroy my hair follicles to the absolute best of its ability. My hair loss probably wouldn't stop even if I castrated myself.

- - - Updated - - -

ok I do not know how to tag :/

Have you tried dutasteride and finasteride at the same time?
My case is like yours, but I've recently taken finasteride oraly and a mixture of minoxidil and a capsule of dutasteride topicaly everyday, the result was amazing and you'll see it after three weeks. However, my hair loss started after a month.
I wish you more luck if you give it a try.

 

[BaldingHelpMe]

Have you tried dutasteride and finasteride at the same time?

Don't take both drugs at the same time or same day, you're going to lose even more hair!

 

[abcdefg]

I was reading up on the pharmacodynamics and kinetics of dutasteride, and it inhibits literally 99.9% of molecules that cause hair loss. So I was wondering how it scientifically possible that people STILL lose hair on dutasteride? Maybe I'm missing something..?

Because we still dont understand the biggest piece. Why is hair sensitive to DHT at all? The sensitivity to androgens has and was always the key to the whole thing and no one knows yet. If your were super sensitive to androgens maybe 1 percent of DHT is still enough. Maybe in some men even in the absence of DHT then T is able to still slowly continue the hair loss process. No one knows. The majority of men though maybe even all of them would prevent male pattern baldness if taken at the very first signs of male pattern baldness. Maybe even before male pattern baldness ever started. Another piece is timing. male pattern baldness might not be reversible once it starts but it might be preventable. So taking it 1 year later might give different results than had you taken it before you even needed it

 

[Sanchez1234]

@Ventures Bro ... I began finasteride in min 2013 and was on it for 6 months with not even 1% of improvement until I panicked and jumped to dutasteride in Dec 2013. Basically it's been more than a year since I've been on dutasteride and I've only lost more and more hair. It's almost gona be 2 years now that I've been on anti androgens. My hairloss is like if Hulk were given Ironman's suit and Thor's hammer with Superman's powers and asked to destroy my hair follicles to the absolute best of its ability. My hair loss probably wouldn't stop even if I castrated myself.

- - - Updated - - -

ok I do not know how to tag :/

How is your hair now?

Have you tried dutasteride and finasteride at the same time?
My case is like yours, but I've recently taken finasteride oraly and a mixture of minoxidil and a capsule of dutasteride topicaly everyday, the result was amazing and you'll see it after three weeks. However, my hair loss started after a month.
I wish you more luck if you give it a try.

How is your hair now?





Anybody got updates? Dutasteride, finasteride and RU are all doing nothing for me....

 

[nicksparrow]

It's as simple as this. If Dutasteride isn't working for you, you either have fake ones or your hairloss is caused by something else or you haven't given it enough time to affect your body.

 

[Sanchez1234]

It's as simple as this. If Dutasteride isn't working for you, you either have fake ones or your hairloss is caused by something else or you haven't given it enough time to affect your body.

Well, it is not working for me, just like finasteride and RU. My meds are real so its caused by something else.

Whats next after all of this dont work? Are there other (experimental) things i could try?

 

[Dontwannabeabetabob]

Well, it is not working for me, just like finasteride and RU. My meds are real so its caused by something else.

Whats next after all of this dont work? Are there other (experimental) things i could try?

How long have you been on dutasteride?

 

[Sanchez1234]

How long have you been on dutasteride?

About 4 months. I know you have to wait atleast 12 months but just like finasteride it does nothing.

I would kill for some less libido and more hair but i have no sides, just like finasteride.

 

[Dontwannabeabetabob]

About 4 months. I know you have to wait atleast 12 months but just like finasteride it does nothing.

I would kill for some less libido and more hair but i have no sides, just like finasteride.

I don't have any sides either, when I added the dutasteride after about a week on it for 36 hoursish I felt very fatigued but that's about it. I haven't lost more hair so technically that's a success, would like to see regrowth obviously.

 

[UnknownT]

I am losing hair on dutasteride. All angrogens cause hairloss for me so I need to get on a strong topical anti-androgen soon or I will lose more hair. Already on ru for 1 month but it has made no difference and i question how true its antiandrogenic qualities are

How long have you been on dutasteride for? Do you take .5mg daily?

 

[abcdefg]

Taking dutasteride early on before or very very early on into male pattern baldness process is a lot different than taking it a few years after your a Norwood 3 already. Once male pattern baldness starts DHT is no longer the main factor the giant complicated cascade of events has already started. DHT is only the initial trigger so you need to prevent it early on. Timing is a key issue with why some men dont regrow or even just maintain. They took it too late into the process.
Castrated men do not regrow hair. They simply keep it. No AA finasteride,dutasteride, something more powerful can ever regrow hair. DHT is not the answer to this. Its the WNT pathway IMO.