thanks cyrus. I believe it should not be much of a problem using it with minoxidil only. How about your experience being on it for the last one month, is it a gamechanger and does it make application supereasy?I use this with rogaine only. I have had rogaine in it now for over a month without cleaning. The minoxidil or ppg, not sure which, does crystallize at the tips of the brush teeth, where liquid is dispensed, after a day or 2 but I I just continue brushing through to unclog them. When I run out of the supply of rogaine in the brush I will definitely clean the brush, as it could use it.