I will start Exosome treatment soon - Day 0 :-)

[Arthurandsam]

Photos of progression under exosomes​

== +18 weeks progress (4,5 months) ==​

Top view, just after exosome treatment -the hair is soaked by the product :

View from above, after the shampoo and towel-dried but still wet hair the next day :

 

[Get my hair back]

Hi. Can you tell me more about what kind of company and where you are going to take human stem cells for hair growth?

 

[Arthurandsam]

Hello,

I use ASCE+ HRLV from EXOCOBIO since 5 months now (https://suiviexo.000webhostapp.com/index-en.html). These exosomes are derived from rose plant stem cells and are not from human. This seems to bring a little benefit but nothing extraordinary at the moment : https://suiviexo.000webhostapp.com/progression-en.html

I will switch to AAPE from ABIO materials wich are exosomes derived from adipose human stem cells, hoping it will give me better results ...

I cannot use finasteride, I use topical minoxidil + Fluridil + CosmeRNA from more than 1 year now and Exosomes from 5 months

 

[Get my hair back]

You wrote about switching to human ones in another thread.
Plant exosomes are useless. I hope you have better luck with human ones.
Keep us posted and good luck.

 

[Arthurandsam]

I dont know if rose stem cell exosomes are completly useless because a lot of micro RNA they give are the same found in human one and are the one useful for hairloss :

Among the microRNAs identified as having an impact on hair growth, there are a number of interesting ones:

• miR-1-3p: As its level decreases, DKK1 increases
• miR-let-7a: Action to regulate hair growth by targeting c-Myc, IGF-1R and FGF5.
• miR-let-7b: Action to regulate hair growth by targeting EDA.
• miR-21: Action to regulate hair growth by targeting CNKSR2, KLF3 and TNPO1.
• miR-29a/B1: Negative action because its overexpression induces hair loss by targeting Wnt and BMP.
• miR-103/107: Positive action by activating PKC signaling, which maintains the quality of differentiated cells (quality that decreases with age).
• miR-130a-3p: Positive action by regulation of TGF-beta;
• miR-130a inhibits TFG-beta activation by targeting the TGFBR1 receptor (found in MSCs).
• miR-214: Negative action by inhibiting the Wnt pathway.
• miR-122-5p: Effect of inhibiting DHT on follicles by targeting the TGF-beta1/SMAD3 signaling pathway

Among those that are also found in MSC exosomes or extracts from dermal papilla stem cells are: miR-let-7a-5p, miR-let-7b-5p, miR-let-7c-5p, miR-let-7f-5p, miR-let-7f-5p, miR-let-7g-5p, miR-let-7g-5p, miR-let-7i-5p, miR-1-3p, miR-122-5p, miR-1246, miR-130a-5p, miR-1246, miR-130a-5p 3p, miR-21-5p, miR-214-3p, miR-23a-3p, miR-23b-3p, miR-29b-3p, miR-4488.

... but yes I hope human exosomes will give me better results ! time will see

 

[Arthurandsam]

For information, I received my AAPE box from South Korea for hair and on the label it says that the exosomes come from deer velvet stem cells...

So I contacted the company ABIO material and they explained to me that they have to modify the label for export authorizations in certain countries. So they stuck a special label for my country on the box :

These are therefore human exosomes...

I'm starting my first application next Friday

I will do 1x every 2-weeks for 6 months (12 times), and then 1x every month (I have also one last vial of ASCE+ HRLV left which I will do in addition the week following my first application of AAPE).

 

[Arthurandsam]

Just fo information, AAPE are not asc-exo (exosomes from adipose stem cell) but asc-cm (conditioned media from adipose stem cells), called secretomes.

ASC-CM is a complex cocktail of proteins, nucleic acids, and lipids released as soluble factors and/or conveyed into extracellular vesicles (EV).

The difference between the secretome molecules is mainly the size of their particles. The microvesicles are larger, about 150 to 1000 μm, while the exosomes are smaller, about 30 to 150 μm. Exosomes penetrate better the skin.

The secretome is the totality of all substances released by stem cells to the outside. These include micro-vesicles, exosomes, proteins, cytokines (cell messengers), hormone-like substances and so-called immunomodulatory substances.

Secretome and exosomes are sometimes used as synonyms, but they are actually different.

The secretome is the totality of all messenger substances released to the outside, including the micro-vesicles and exosomes, but also other important factors that are dissolved in the fluid. These include many regeneration-promoting growth factors and so-called cytokines (cell-cell messengers).

Exosomes, on the other hand, are actually only the particulate exosomes that are isolated from the whole. Isolation concentrates them, but the important solutes and micro-vesicles are lost.

I am not a specialist but imo exosomes carry more microRNA than secretomes as they are more filtred and so they can stimulate for example the wnt/beta-catenin pathway wich is very important for hair loss.

I found some research paper showing that asc-cm work great for hair loss.

So I will continue to take exosome from ASCE, but now also adding AAPE.

I think the microRNA are important.

Problem is ASCE are exosomes derived from plant and not from human.

There are company who sell human adipose exosomes but price is very expensive...

If I found human exosome I will take it instead of ASCE, but for the moment I found no one.

Even rose exosome carry a lot of good microRNA, as I explain earlier... So I think it's a good add-on to AAPE.

Price for exosome from human umbilical from Creative Biolab is about 350USD per vial... And you are to add 300USD for shipping. It's very expensive...

I am waiting for the price for adipose exosomes from human, I will update when I receive it

EDIT : Creative Biolab offer human Umbilical exosomes for hair loss. I bought 10 vials and will use it as a add-on to the AAPE secretomes extracted from adipose tissue. This combo will give me a lot of proteins and growth factors from different souces, and a lot of good micro RNA. See you in 3-4 months

 

[Arthurandsam]

Update at 24 weeks :

Top view, just after exosome treatment -the hair is soaked by the product :

View from above, after the shampoo and towel-dried but still wet hair the next day :

Updated May 2024: As mentioned in the previous text, the ASCE+ HRLV product is based on plant-derived exosomes (rose). After 20 weeks of treatment, it brought me a little benefit but nothing extraordinary... so I decided to change the product. I now move on to the following products that rely on human sources:

• AAPE Hair (ABIO material): These are secretomes derived from human adipose tissue.
• Exosomes for hair (Creative Biolab): These are exosomes from human umbilical cord.

For information, AAPEs are not ASC-EXOs (exosomes from adipose stem cells) but ASC-CMs (conditioned media from adipose stem cells), called secretomes.

ASC-CM is a complex cocktail of proteins, nucleic acids, and lipids released as soluble factors and/or transported in extracellular vesicles (EVs). The difference between secretome molecules lies mainly in the size of their particles. Microvesicles are larger, approximately 150–1000 μm, while exosomes are smaller, approximately 30–150 μm. Exosomes therefore penetrate the skin better.

Secretome and exosomes are sometimes used synonymously, but they are actually different.

The secretome is the collection of all messenger substances released to the outside, including microvesicles and exosomes, but also other important factors dissolved in the liquid. These include many growth factors that promote regeneration and so-called cytokines (cell-cell messengers).

Exosomes, on the other hand, are actually just particulate exosomes isolated from the whole thing. Isolation concentrates them, but important solutes and microvesicles are lost.

In my opinion, exosomes carry more microRNAs than secretomes because they are more filtered and can therefore stimulate, for example, the wnt/beta-catenin pathway which is very important for hair loss.

So I'm going to continue taking exosomes, but now also adding AAPE and making sure the sources are human and not plant-based. I take this combo because I think microRNAs are important in addition to the various proteins/growth factors.

You will find the list of microRNAs found in exosomes from adipose tissue and umbilical cord in this research paper: "Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells". By comparing them with the list of microRNAs which have an impact on hair (see this research paper : "Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy"), it seems that there are more of them than in the exosomes from rose... which is a good point !

 

[Get my hair back]

Afternoon! Update?