Remember, on the scalp you are swimming against the current, so even if active minoxidil is reaching the follicle it may not be strong enough to overcome the resistance. Non-balding follicles don't face the same resistance.does the minoxidil need to be converted to its active metabolite to provoke the unwanted body hair effect? from my experience even dose as low as 0.625 mg cause more side effect than massive dosage of topical ( 8 ml a day)