If Finasteride Is As Effective As Claimed

shidoin

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Yeah, great words wemustchange.

The thing is DHT is not the only issue here. In theory finasteride inhibits 5ar from reducing testosterone and DHEA into more powerful forms of androgens. But thats only half of the equation. Simplifying: [androgen] + [androgen receptor] <-> [gene expression].
Reducing androgens will reduce the extension of the reaction. However, there are several mechanisms within our cells that can mediate gene expression throught co activators and other facilitators that ultimately end up increasing the mRNA transcriptional factors resulting in "one androgen" producing more target proteins by the rybosome than what it should be producing. Thats what people usually call as "sensivity".

So yeah, if you think getting on finasteride is going to save your hair, forget it. It might only get you some years tops. The best thing you can do here is a combination of treatments such as 5ar inhibitor + topical androgen antagonist + (maybe) systemic antiandrogen IF you feel like taking the chance (notice there are weak treatments such as spironolactone or stronger such as cypro). This is as far as you can get to prevent hair loss. To stimulate regrowth, which is fairly a different story, your best option is minoxidil and maybe topical estradiol.
Topical estradiol was tried by others 15+ years ago. Is great if your a tranny! With minoxidil the hairs become addicted to the drug, so if you stop everything is lost. I've been on 5ar's plus nizoral and topical essential oils for 20 years and have maintained a Norwood 3.
 

Hairicane

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Be completely content if you can maintain. Even if your forelock is fucktus, as long as it doesn't creep into massive crown loss you need to accept that as ultimate victory. At 20, I felt like if I didn't get back to a NW1 it was a failure, which caused me to cease treatments multiple times out of frustration which was a grand mistake! Maintain at a NW3 with proven treatments and save for a transplant. That's how you win until a miracle cure comes along. The science says the proven meds are most likely going to give you just that.

I don't think I'll see a miracle cure in my life. I can remember when I first noticed my hairline receding back in 1996, and this rumored miracle cure was coming soon. That was finasteride. Good but not a silver bullet miracle cure. I wonder if there will ever truly be one.
 

shidoin

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I don't think I'll see a miracle cure in my life. I can remember when I first noticed my hairline receding back in 1996, this rumored miracle cure was coming soon. That was finasteride. Good but not a silver bullet. I wonder if they will ever truly be one.
Was definitely not a silver bullet, but it does work for most. My opinion the best treatment is the one that you find that works for you. If its rubbing cow pee on your head so be it!
 

Hairicane

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Topical estradiol was tried by others 15+ years ago. Is great if your a tranny! With minoxidil the hairs become addicted to the drug, so if you stop everything is lost. I've been on 5ar's plus nizoral and topical essential oils for 20 years and have maintained a Norwood 3.

The studys I've seen show with minoxdil after two years hair counts drop below baseline, even with the very best responders. This is because it merely encourages hair to stay in anagen longer, but it can't keep it there forever of course. When it cycles back dht will do it's job.
 

Hairicane

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Was definitely not a silver bullet, but it does work for most. My opinion the best treatment is the one that you find that works for you. If its rubbing cow pee on your head so be it!

I just wish I started looking for what works ten years ago.

I'm going to give finasteride a shot, if it doesn't work I'll talk to you about dutasteride, or just take my wife's advice and shave it and move on with life.
 

shidoin

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The studys I've seen show with minoxdil after two years hair counts drop below baseline, even with the very best responders. This is because it merely encourages hair to stay in anagen longer, but it can't keep it there forever of course. When it cycles back dht will do it's job.
You need to block dht as well. Biotin also increases the anagen cycle. I used it (minoxidil) for a few months but the puffy face and eyes I got wasn't worth it. Rosemary oil has been shown to be as effective as 2% minoxidil
 

shidoin

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I just wish I started looking for what works ten years ago.

I'm going to give finasteride a shot, if it doesn't work I'll talk to you about dutasteride, or just take my wife's advice and shave it and move on with life.
If your only Norwood 3 most likely you will regrow hair and maintain. I'm a 3 but was at a Norwood 3v. I took crazy amounts of 5ar inhibitors for a few months. 5 mg proscar and 0.5- 1 mg dutasteride daily for about 6 months. I had the most regrowth then. It was like a cancer survivor regrowing hair. But I stepped back because of financial difficulties at the time
 

Hairicane

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If your only Norwood 3 most likely you will regrow hair and maintain. I'm a 3 but was at a Norwood 3v. I took crazy amounts of 5ar inhibitors for a few months. 5 mg proscar and 0.5- 1 mg dutasteride daily for about 6 months. I had the most regrowth then. It was like a cancer survivor regrowing hair. But I stepped back because of financial difficulties at the time

Is the "dht itch" a real thing? I've read on these forums for a long time and come across that often.

Over the years I've often felt a tingling little itch on my scalp, often at the hairline as it creeped back. Is that dht attacking the follicle?
 

shidoin

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Is the "dht itch" a real thing? I've read on these forums for a long time and come across that often.

Over the years I've often felt a tingling little itch on my scalp, often at the hairline as it creeped back. Is that dht attacking the follicle?
I had that in my 20's early 30's you can combat that with 1% nizoral and also using a few tablespoons of organic apple cider vinegar in a 1/2 gallon of water as a final rinse
 

Chemichal Castration

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Topical estradiol was tried by others 15+ years ago. Is great if your a tranny! With minoxidil the hairs become addicted to the drug, so if you stop everything is lost. I've been on 5ar's plus nizoral and topical essential oils for 20 years and have maintained a Norwood 3.

I dont think you go "tranny" with topical use of a small concentration of estradiol. It was only a suggestion, there are similar alternatives for topicals with less risk of loosing you manly hood.

I dont like minoxidil, personally. In my opinion the best treatments should be consistent and minoxidil isnt. Its more like a emergency drug imo
 

shidoin

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I dont think you go "tranny" with topical use of a small concentration of estradiol. It was only a suggestion, there are similar alternatives for topicals with less risk of loosing you manly hood.

I dont like minoxidil, personally. In my opinion the best treatments should be consistent and minoxidil isnt. Its more like a emergency drug imo
All tropicals go systemic
 

Jakejr

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As far as medical science goes, Duasteride is their best product for male pattern baldness. I don’t want to take Finasteride or Duasteride orally, so I have a topical of Finasteride/Minoxidil which hasn’t really done much. But today I got a Duasteride topical & see how that goes. Clinical studies of weekly scalp injections with Duasteride look encouraging. I’ll just microneedle for now.
 

shidoin

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As far as medical science goes, Duasteride is their best product for male pattern baldness. I don’t want to take Finasteride or Duasteride orally, so I have a topical of Finasteride/Minoxidil which hasn’t really done much. But today I got a Duasteride topical & see how that goes. Clinical studies of weekly scalp injections with Duasteride look encouraging. I’ll just microneedle for now.
Topical isn't nearly as strong and still goes systemic! It only helps you mentally! They created the topical versions because so many are afraid to take oral medications
 

dralex

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Comparing the amount of people that are losing their hair and are on treatments is a much much larger group than on this forum. This forum consists mostly of non-responders and people who had side effects, thats why you see such a larger portion of people that aren't responding on here. I was still losing a lot of hair for 2 years on finasteride and am still losing on dutasteride. Do I believe I am a minority? Yes, studies are not fabricated. Most people respond well, but not everyone does.

The people that claim it isn't possible to lose hair on dutasteride are frankly just ignorant. Not everyone responds and everyone knows this. It is possible the medication isn't working to lower my DHT as I have never had my DHT levels checked, but who knows. I could get it checked, but what is that going to do for me? I haven't responded to dutasteride, finasteride, or minoxidil.

Some people who do respond extremely well like to claim this drug is a miracle and how it will definitely stop hair loss and grow some back, because it did for them. Not everyone responds the same to every drug. People will be non-responders, studies show it.
 
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Father_of_Shiseido

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I've only been on finasteride a month but I'm trying to find out from long time finasteride users if there are any early indications of being a good responder.

I take it that you responded well. Did you see any change in your hair or body in the first few months?

If I could just hold on to my Norwood 3 I'd he on cloud 9.
I responded well but even on this drug one would continue to thin (slowly) in a pattern which he has inherited.
 
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