Interesting you mention that. I got huge facial bloatedness after 8 months of taking duta, literally took 8months before the sides kicked in. I also lost half of my beard density, both happened at the same time. It is hard to say whether higher E was responsible for it though, as low dht does contribute to lesser bodily/facial hair and fat control (in some way). The face fat is water retention and idk if dht does anything about that, maybe it really was a sudden spike in E that caused it for some reason. Making me reconsider applying small dosages of estriol.