Is Seti Or Pge2 Insomnia Permanent?

[Sliceofbread]

Any other sides @RU serious ? Are you thinking clearly with motivation intact? Looks like this could cause depression based on studies I've read. PGD2 is also a neuroprotectant.

I'm fixing to join the club but I'm not naive to the risks we're taking.

Seems mostly from dp1 and dp2 receptors from what I can find. Bit confused but from what I’m seeing crth2 knockout mice were actually protected from depression induced isolation and nmda receptor inhibition. So I’m guessing decreasing crth2 in the brain does have a neuroexcitatory effect (explains occasionally anxiety and insomnia).

Does seem alittle ominous to me... could be something that ends up being linked to dementia in the long term.

 

[yourMom<3sMyHair]

How are the results?

Also curious in your results @RU serious .

 

[yourMom<3sMyHair]

Seems mostly from dp1 and dp2 receptors from what I can find. Bit confused but from what I’m seeing crth2 knockout mice were actually protected from depression induced isolation and nmda receptor inhibition. So I’m guessing decreasing crth2 in the brain does have a neuroexcitatory effect (explains occasionally anxiety and insomnia).

Does seem alittle ominous to me... could be something that ends up being linked to dementia in the long term.

I agree, this can't be good in the long run. My hope is to get on until RCH-01 is available. Hopefully, this will be 3 years max of seti and assumes I tolerate the drug well. Just hoping the damage won't be significant and that all returns to normal when usage is ceased.

 

[ffar1989]

Dude. Get a job. Do your homer work. No one is able to say much about seti.

 

[Sliceofbread]

I agree, this can't be good in the long run. My hope is to get on until RCH-01 is available. Hopefully, this will be 3 years max of seti and assumes I tolerate the drug well. Just hoping the damage won't be significant and that all returns to normal when usage is ceased.

Ya man my hope too. Eventually I think I’ll be more okay with balding too.

Gonna start up with 500mg and increase until I get maintenance, keep as low dose as needed

 

[RU serious]

Only side effects are dry mouth.

I’m fairly sure that I’m maintaining, I’m 25 with aggressive male pattern baldness. My crown hasn’t changed in this whole 6 months.

For the record finasteride worked for me but gave me bad side effects. Topical finasteride, RU, did not work.

I’ve also been using cetirizine topically with water. And have recently bought a sub dermal applicator with tiny needles to help with penetration of cetirizine. May as well go all out with PGD2 approach now.

I was NW4 going on 5 at 24 years old. Hair transplant and seti has (so far) been my cure.

 

[Sliceofbread]

Only side effects are dry mouth.

I’m fairly sure that I’m maintaining, I’m 25 with aggressive male pattern baldness. My crown hasn’t changed in this whole 6 months.

For the record finasteride worked for me but gave me bad side effects. Topical finasteride, RU, did not work.

I’ve also been using cetirizine topically with water. And have recently bought a sub dermal applicator with tiny needles to help with penetration of cetirizine. May as well go all out with PGD2 approach now.

I was NW4 going on 5 at 24 years old. Hair transplant and seti has (so far) been my cure.

Nice dude! Wish my seti would get here. I am also doing topical ceti

 

[Bigoldben]

Only side effects are dry mouth.

I’m fairly sure that I’m maintaining, I’m 25 with aggressive male pattern baldness. My crown hasn’t changed in this whole 6 months.

For the record finasteride worked for me but gave me bad side effects. Topical finasteride, RU, did not work.

I’ve also been using cetirizine topically with water. And have recently bought a sub dermal applicator with tiny needles to help with penetration of cetirizine. May as well go all out with PGD2 approach now.

I was NW4 going on 5 at 24 years old. Hair transplant and seti has (so far) been my cure.

How much do you pay for it?

 

[RU serious]

How much do you pay for it?

It’s $6.5 per gram from lyphar. I live in the uk, with shipping included I pay just under £200 a month, £2400 a year.

 

[blah121]

I've been thinking and with regards to insomnia it could be that this drug kills the REM function of sleep when you take it but the body might just reproduce the function by the time you reach that stage during sleep if you take the drug early enough. I think if insomnia was permanent people would've already complained about it since they seem to be directly linked by a lot of people taking high doses having some sleep problems.

So maybe insomnia isn't permanent but the brain fog aspect probably leads to depression and other problems down the road.

I never would've thought there would be a new drug as effective as finasteride out by now, who knows what could become available next year or the year after. I think I'd just rather be bald for a few years than take further risks as I've been burned by finasteride in the past.

 

[d3nt3dsh0v3l]

Only side effects are dry mouth.

I’m fairly sure that I’m maintaining, I’m 25 with aggressive male pattern baldness. My crown hasn’t changed in this whole 6 months.

For the record finasteride worked for me but gave me bad side effects. Topical finasteride, RU, did not work.

I’ve also been using cetirizine topically with water. And have recently bought a sub dermal applicator with tiny needles to help with penetration of cetirizine. May as well go all out with PGD2 approach now.

I was NW4 going on 5 at 24 years old. Hair transplant and seti has (so far) been my cure.

What kind of topical finasteride did you use (dosage, concentration, vehicle, etc.)? Did you make it and how? How often did you use it and for how long? What made you decide to stop/when did you decide to stop and what convinced you that it was not working?

 

[RU serious]

What kind of topical finasteride did you use (dosage, concentration, vehicle, etc.)? Did you make it and how? How often did you use it and for how long? What made you decide to stop/when did you decide to stop and what convinced you that it was not working?

Hassan & Wong 0.2% (because higher dose gave me sides) every day for 9 months. Because I lost a ton of ground

 

[yourMom<3sMyHair]

I agree, this can't be good in the long run. My hope is to get on until RCH-01 is available. Hopefully, this will be 3 years max of seti and assumes I tolerate the drug well.

Hassan & Wong 0.2% (because higher dose gave me sides) every day for 9 months. Because I lost a ton of ground

I was on H&W regular strength for weeks at a time and couldn't sleep for the life of me. Never went away. Also started getting anxiety like on oral.

Hoping that it wasn't the same mechanism as the seti insomnia.

 

[yourMom<3sMyHair]

I've been thinking and with regards to insomnia it could be that this drug kills the REM function of sleep when you take it but the body might just reproduce the function by the time you reach that stage during sleep if you take the drug early enough. I think if insomnia was permanent people would've already complained about it since they seem to be directly linked by a lot of people taking high doses having some sleep problems.

So maybe insomnia isn't permanent but the brain fog aspect probably leads to depression and other problems down the road.

I never would've thought there would be a new drug as effective as finasteride out by now, who knows what could become available next year or the year after. I think I'd just rather be bald for a few years than take further risks as I've been burned by finasteride in the past.

Doesn't look like PGD2 is responsible for REM sleep:

https://www.ncbi.nlm.nih.gov/pubmed/22024172

 

[yourMom<3sMyHair]

This book indicates that the DP1 receptor is responsible for PGD2's role in sleep, not DP2:

https://books.google.com/books?id=P...QhPMAc#v=onepage&q=dp2 receptor sleep&f=false

Blocking DP2 with seti would leave more PGD2 to bind to DP1, correct? This might explain the sleepiness some users report upon ingestion?

If so, what is causing the insomnia?

 

[killDHT]

Nice dude! Wish my seti would get here. I am also doing topical ceti

Does cetirizine work for you?