URGENT@ hair-cook DID SOME DIGGING. can you give me more info on what the concensus was regarding PTGDS and its inhibition. as it seems form what i read that unless this is addressed seti on its own, or even the ghetto/kitchen sink protocol results will be negatively impacted!
https://www.hairlosstalk.com/interact/threads/sertaconazole-nitrate-increases-pge2.110617/
text below taken/quoted from the link:-
"Wow, that's some great insight.Thanks man, helps having people like you around
There's still a problem: Highly overexpressed PTGDS in keratinocytes of balding hair follicls will outcompete PTGES for PGH2 and probably make much more PGD2 than PGE2. Even if you block the PGD2 receptor, cells will still make much less PGE2 because of this. Here's a drawing:
Damn that sucks. I wonder how much we can control PTGDS right now in combination with retinoids, castor and selenium sulfide (guess not even remotely enough) :/
I guess this also explains why a lot of people did not have any results with seti alone (low dose topically in german forums), you need actually exogenous PGE or a PTGDS Inhibitor to restore PGE-Levels.
But tough luck for us - Humans have very few gamma-delta T cells in our skin, so we don't get that same benefit. (source)
Notably, humans lack a robust population of resident dermal γδ T cells, potentially explaining their inability to regenerate hair after wounding.
Wow, that's seriously taking some wind out of castor oil then for me. Heck, we probably need even some exogenous FGF-9 if there no other way of building it. At least there seem to be a few things in the pipeline that consider these findings."
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why aren't people adding one of the following as an adjunct?
natural ptgds inhibitors
https://www.hairlosstalk.com/interact/threads/rutin-as-ptgds-inhibitor.96364/