Italian Hair Loss Lotion To Hit The Market In 2016

kawnshawn

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Folks,

I've been working with a group of biochemists and Nano-medicine scientists. I've been told by experts in the field that the Brotzu lotion has a "low" concentration of the bio actives in the vesicle.

Furthermore, the usual encapsulation efficiency for a liposome is 10-20% of the original active substance, Brotzu mentions he got higher than 80% which makes no sense as a lot of bio active gets lost in the preparation process and sonication.

The liposome in the patent mentions an "unbelievably" high encapsulation efficiency. Which makes it questionable!

Also, in working with the scientists at the labs, I was informed that liposomal science is undergoing a change in thinking as liposomes don't necessarily transport active drug /cosmetic (eg S-Equol, DGLA and Carnitine) to the skin, it breaks on contact. So these compounds don't get under the skin via liposome, so the next question is , will a topical application allow them to pass the skin barrier?

The following article from research at the University Southern Denmark speaks to it.

I've been working hard to get Broztu's lotion prepared in a proper research lab, and I've supplies lined up from the major distributors, but, this entire procedure in his patent is not adding up or making sense when the nano-medicine group that's helping me to reproduce it is reviewing it.

Remember, these people I am working with are professional nano-medicine scientists and liposome and nano-particle manufacturing for pharmaceutical applications is their bread and butter, and this is not their first rodeo. I'm paying a big price tag to keep experts engaged to ensure fidelity to the protocol as close as possible.

For once and for all I want to get this lotion produced and tested with proper results and as close adherence to Brotzu's original protocol to debunk or to validate Broztu's claims. Clearly, FIDIA will take eons to respond or validate.

So the citizen community activists like myself have taken this up to validate it . The lotion production is cost prohibitive overall, it's around $7,000 usd for the preparation and HPLC and particle size testing to ensure its a lipsome and not a lipid aggregate that often masks as a liposome and has the drug has a decent encapsulation. Then, there's additional cost for materials.

Honestly, in the labs with the biochemists and nano-medicine scientists reading the procedure, many are doubtful of the science overall.

Don't want to burst anyone's bubble.

@Swoop & @hellouser, can you guys chime in too ?

Here's the article in news and academic publications :

http://sciencenordic.com/liposomes-skin-creams-don’t-work


Article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709185/
Which is exactly why FIDIA is conducting trials, to see if the product works. Brotzu has shown results of the child with AA and the results of the women with Androgenetic Alopecia, so I don't think a person can claim that liposomes are a dud if there are documented results. The trials have ended and now all we can do is wait at least a month or two before any info is released.
 

JakeSmores80

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Which is exactly why FIDIA is conducting trials, to see if the product works. Brotzu has shown results of the child with AA and the results of the women with Androgenetic Alopecia, so I don't think a person can claim that liposomes are a dud if there are documented results. The trials have ended and now all we can do is wait at least a month or two before any info is released.

1-2 months is an arbitrary timeframe. It can be a year too right? The trials on Bimataprost are classical example, Allergan took forever to release the dismal trial results .
 

paxis

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Well, senior Brotzu sent me an email yesterday, and this what he had to say

Good evening Mr ****,

Regarding the Brotzus lotion, i just wanted to ask you if you know if it works for Androgenetic Alopecia as well as for AA.
And, if its not too much of a trouble, wanted to ask if you know when can we expect an official announcment from FIDIA?

with respect,
Dr Brotzu.


f*** y'all pathetic assholes, Im out of here!
I dont even know what u are trying to say.. this makes no sense, not even for a troller..
 

kawnshawn

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1-2 months is an arbitrary timeframe. It can be a year too right? The trials on Bimataprost are classical example, Allergan took forever to release the dismal trial results .
Do I believe it will take longer than at least 2 months for them to release info? No. It is your money so it's your prerogative if you want to spend it on a custom lotion. I believe that its important though to give both sides of the argument with claims that liposomes aren't effective and others who say the patent makes no sense when there are documented results that the lotion did stop shedding and had some regrowth in Brotzu trials.
 

Janks16

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I did get one bottle . I did not get any results from that, I applied it.

The Italian group buy guy also said his formulation was unstable and he stopped responding to emails or messages.

Also, if it worked, shipping with local courier did not work best.

Given that the lotion was couriered in fall of last year and in transit for 30 days , it was subjected to extreme winter temperatures in North America and the liposomal formulation was subjected to temperature changes which made them break down anyways.

Brotzu's recipe is unstable already, plus temperature differences beyond control of shipping carrier and aerosol spray tip attached to the bottle in which the lotion came, can break down the liposomes. That's why brotzu and Beps used the "dropper"

If your scientists are so incredibly knowledgeable, they should able to create their own lotion for hair growth. But that's not the case, is it? Just like anyone else on this board, they can only speculate because they don't have Fidia's lotion, nor the exact formula to recreate it and observe its efficacy. The only one who knows if this works are the folks at Fidia. Time will tell.
 

Roberto_72

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If your scientists are so incredibly knowledgeable, they should able to create their own lotion for hair growth. But that's not the case, is it? Just like anyone else on this board, they can only speculate because they don't have Fidia's lotion, nor the exact formula to recreate it and observe its efficacy. The only one who knows if this works are the folks at Fidia. Time will tell.
Tomorrow most people in Northern Italy return from Winter vacations, including the fellows at Fidia.
I will call them on next Friday trying to get some info. I say Friday because before that date they will probably be swamped with emails and backlog.

If they do not reply I will chain myself to the closest tree in front of the company until they give a date!






j/k for the chain part
 

FutureSaitama

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Tomorrow most people in Northern Italy return from Winter vacations, including the fellows at Fidia.
I will call them on next Friday trying to get some info. I say Friday because before that date they will probably be swamped with emails and backlog.

If they do not reply I will chain myself to the closest tree in front of the company until they give a date!






j/k for the chain part
No jk. Bring two chains and tie me up with you.
 

Abelibano

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Folks,

I've been working with a group of biochemists and Nano-medicine scientists. I've been told by experts in the field that the Brotzu lotion has a "low" concentration of the bio actives in the vesicle.

Furthermore, the usual encapsulation efficiency for a liposome is 10-20% of the original active substance, Brotzu mentions he got higher than 80% which makes no sense as a lot of bio active gets lost in the preparation process and sonication.

The liposome in the patent mentions an "unbelievably" high encapsulation efficiency. Which makes it questionable!

Also, in working with the scientists at the labs, I was informed that liposomal science is undergoing a change in thinking as liposomes don't necessarily transport active drug /cosmetic (eg S-Equol, DGLA and Carnitine) to the skin, it breaks on contact. So these compounds don't get under the skin via liposome, so the next question is , will a topical application allow them to pass the skin barrier?

The following article from research at the University Southern Denmark speaks to it.

I've been working hard to get Broztu's lotion prepared in a proper research lab, and I've supplies lined up from the major distributors, but, this entire procedure in his patent is not adding up or making sense when the nano-medicine group that's helping me to reproduce it is reviewing it.

Remember, these people I am working with are professional nano-medicine scientists and liposome and nano-particle manufacturing for pharmaceutical applications is their bread and butter, and this is not their first rodeo. I'm paying a big price tag to keep experts engaged to ensure fidelity to the protocol as close as possible.

For once and for all I want to get this lotion produced and tested with proper results and as close adherence to Brotzu's original protocol to debunk or to validate Broztu's claims. Clearly, FIDIA will take eons to respond or validate.

So the citizen community activists like myself have taken this up to validate it . The lotion production is cost prohibitive overall, it's around $7,000 usd for the preparation and HPLC and particle size testing to ensure its a lipsome and not a lipid aggregate that often masks as a liposome and has the drug has a decent encapsulation. Then, there's additional cost for materials.

Honestly, in the labs with the biochemists and nano-medicine scientists reading the procedure, many are doubtful of the science overall.

Don't want to burst anyone's bubble.

@Swoop & @hellouser, can you guys chime in too ?

Here's the article in news and academic publications :

http://sciencenordic.com/liposomes-skin-creams-don’t-work


Article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709185/

First of all,look at the comments at the bottom of your link.2 people claim that liposomes do penetrate skin and encapsulate substances correctly.

Second, why did you go to such effort? Even if you really have a lot of money, you can't have access to high end laboratories and the collective knowledge and skills that a group of scientists in a big pharma company has. So it's quite normal if you do not have results...
Although I am very much into applied sciences, I do admit I don't know jack sh*t about chemistry. But what I do know is, the complexity there is very high too,and even the slightest variation matters.You will not be able to replicate FIDIA's lotion if the are using a special technique or a compound that they will not speak about.

Just think of Coke. Many companies will claim that they can also make Coca Cola's Coke because they know MOST of the compounds but in fact they are not aware of the secret ones or of a special technique in production. Their product will never be the same. (and in this case, the product does serves its purpose- it's drinkable and nice. In a drug, a slightest variation could render it useless)
 

cratusg

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Tomorrow most people in Northern Italy return from Winter vacations, including the fellows at Fidia.
I will call them on next Friday trying to get some info. I say Friday because before that date they will probably be swamped with emails and backlog.

If they do not reply I will chain myself to the closest tree in front of the company until they give a date!

Could you please not joke about the chain part? I even bring you the god damn chain myself. Cheerleader team. GTA mode: on, if they call cops. I'm used to playing 6 stars in vice city and San Andreas.




j/k for the chain part
 

The 7TH Sense

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Funny.

http://www.uibm.gov.it/uibm/dati/Avanzata.aspx?load=info_list_uno&id=2258175&table=Invention

Reading the official register of Italian's Patents Office, the first intellectual property passage went from the two Brotzus to "LIPOSOME ADVANCED RESEARCH LLC | 2701 CENTERVILLE RD NEW CASTLE COUNTY WILMINGTON DELAWARE | USA (US) ". That's a big developing centre located in USA. The patent was then acquired, after the results shown at Gaslini, by the company FIDIA. Recently we got the rumor FIDIA bought an enterprise to enlarge the liposomes' production on a mass scale.
On IESON, if I remember correctly, was said that Brotzu's son was the specialist about the liposomes. Effectively, basing on his curriculum, he really is. I could be wrong, but if I remember correctly he had a connection with that institute of research I mentioned.

However, even if I'm not going to believe in your speculations (no photo, no videos, no mentions,no papers), you should know that when posting important accusations like yours, they should be accompanied by proper scientific demonstrations.

Brotzu is a well known and respected professor at UniCA, son of a man who discovered Cefalosporine (!!!) so he surely knows how to approach scientific research. Brotzu spoke at ASAA congress at Genova's Gaslini, maybe the most famous hospital in Italy for the treatment of rare diseases and unkown pathologies. Then he spoke 2 times in the same day at Turin's SITRI (most important tricology congress in Italy) and his discovery was published on italian paper "il Dermatologo" without even being a dermatologist himself.

He has got multiple proves about his words, provided photos and even made a patent out of it.

Then, since you came on a forum to let the world know your opinion and "researches", and since in these case you are the accusation, you should provided, to be considered trustworthy:
- A photo of the lotion you are using with your username attached to it;
- A scan, signed by the laboratory with the name exposed (and his website) of a guarantee of the compounds of the lotion are you using;
- A photo of your (existant or not) results;
- A video of your application of the lotion.

I don't care of what you may say about this, but I hope that you won't get offended if I said that my total attention goes to FIDIA's results and not yours.
However, by the time you will provide the proves (if you will), our results will be probably available and we'll already have grown hairs even on the palm of our hands (don't overhype though). Until that, it's JakeSmores80's word on HairLossTalk.com FORUM against Giovanni Brotzu's word. :)

Sorry, people like to spread hype or panic randomly here, but please it's not a funny game. Since the doctor is "Nanni Brotzu and not God", you have all the possibilities to prove your words.



Folks,

I've been working with a group of biochemists and Nano-medicine scientists. I've been told by experts in the field that the Brotzu lotion has a "low" concentration of the bio actives in the vesicle.

Furthermore, the usual encapsulation efficiency for a liposome is 10-20% of the original active substance, Brotzu mentions he got higher than 80% which makes no sense as a lot of bio active gets lost in the preparation process and sonication.

The liposome in the patent mentions an "unbelievably" high encapsulation efficiency. Which makes it questionable!

Also, in working with the scientists at the labs, I was informed that liposomal science is undergoing a change in thinking as liposomes don't necessarily transport active drug /cosmetic (eg S-Equol, DGLA and Carnitine) to the skin, it breaks on contact. So these compounds don't get under the skin via liposome, so the next question is , will a topical application allow them to pass the skin barrier?

The following article from research at the University Southern Denmark speaks to it.

I've been working hard to get Broztu's lotion prepared in a proper research lab, and I've supplies lined up from the major distributors, but, this entire procedure in his patent is not adding up or making sense when the nano-medicine group that's helping me to reproduce it is reviewing it.

Remember, these people I am working with are professional nano-medicine scientists and liposome and nano-particle manufacturing for pharmaceutical applications is their bread and butter, and this is not their first rodeo. I'm paying a big price tag to keep experts engaged to ensure fidelity to the protocol as close as possible.

For once and for all I want to get this lotion produced and tested with proper results and as close adherence to Brotzu's original protocol to debunk or to validate Broztu's claims. Clearly, FIDIA will take eons to respond or validate.

So the citizen community activists like myself have taken this up to validate it . The lotion production is cost prohibitive overall, it's around $7,000 usd for the preparation and HPLC and particle size testing to ensure its a lipsome and not a lipid aggregate that often masks as a liposome and has the drug has a decent encapsulation. Then, there's additional cost for materials.

Honestly, in the labs with the biochemists and nano-medicine scientists reading the procedure, many are doubtful of the science overall.

Don't want to burst anyone's bubble.

@Swoop & @hellouser, can you guys chime in too ?

Here's the article in news and academic publications :

http://sciencenordic.com/liposomes-skin-creams-don’t-work


Article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709185/
 

Switzer

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Look what I found
giuseppe 2.png

"Activites: CEO Liposome Advanced research LLC delaware USA"

And guys, he has already asked for people who doesn't personally know him to stop contacting him on facebook. So PLEASE don't try to contact him on VK.
 
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hairblues

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Look what I found
View attachment 46948
"Activites: CEO Liposome Advanced research LLC delaware USA"

And guys, he has already asked for people who doesn't personally know him to stop contacting him on facebook. So PLEASE don't try to contact him on VK.

Seen this long time ago

if you go to Italian woman's page (not saying her name) you know who i mean i am sure--they have conversations occasionally on page...nothing really relative to Brotzu except once he asked her how is hair? It was around time of a flood in Sardenia they talked about.
She did ask him how his hair in return but could not tell if it was teasing. I wondered though if he is also using lotion.

https://www.delawarelookup.com/company/5668919/liposome-advanced-research-llc
 

tzt

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Look what I found
View attachment 46948
"Activites: CEO Liposome Advanced research LLC delaware USA"

And guys, he has already asked for people who doesn't personally know him to stop contacting him on facebook. So PLEASE don't try to contact him on VK.
Guisseppe is beps63 ?? because they have the same year of birth 1963 !!
 
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