Italian Hair Loss Lotion To Hit The Market In 2016

[JLC]

Story of the Brotzu

Beginning = Sounds exciting and credible and out very soon.

Middle = Lots of nonsense is posted on forum and only one official statement.

End = Lotion never came out and nonsense posting becomes funny to read as it's comical people are still posting about it. Brotzu get's lumped in with foreskin and apples cream.

 

[17AndBalding]

Story of the Brotzu

Beginning = Sounds exciting and credible and out very soon.

Middle = Lots of nonsense is posted on forum and only one official statement.

End = Lotion never came out and nonsense posting becomes funny to read as it's comical people are still posting about it. Brotzu get's lumped in with foreskin and apples cream.

This will probably be the case for so many more upcoming treatments and will go on ad nauseam. Fml

 

[kiwipilu]

Story of the Brotzu

Beginning = Sounds exciting and credible and out very soon.

Middle = Lots of nonsense is posted on forum and only one official statement.

End = Lotion never came out and nonsense posting becomes funny to read as it's comical people are still posting about it. Brotzu get's lumped in with foreskin and apples cream.

I remember all the guys who immediately jumped on soy supplement wagon...
later started the memes..
now desperation with little bit of light here and there

 

[Janko]

I remember all the guys who immediately jumped on soy supplement wagon...
later started the memes..
now desperation with little bit of light here and there

Y'all talking like it all went through decades.

 

[Ollie]

So let's just go over some stuff again.

Brotzu first discovered that just PGE1 delivered by liposomes caused unexpected hairgrowth on diabetic limbs. At this point, there was no equol or L-carnitine in the formula.

Then, he tries the precursor DGLA instead of PGE1 because PGE1 is a drug and would require trials in Europe. (Sidenote: In 1983, a patent application was made for a shampoo claiming that "the high linoleic acid content of the shampoo is very effective for preventing hair loss and developing or growing hair.")

Yet, in Brotzu's patent, it says the experimental group that used the solution containing only DGLA delivered by liposomes had no effect whatsoever on hair, despite his original discovery of only PGE1 delivered by liposomes causing hair growth, however he still intends for DGLA to replace PGE1.

However, for some magical reason, the arbitrary addition of small amounts of equol suddenly made the DGLA go from doing nothing to outperforming PGE1?

Yet in the experimental group with PGE1 and S-equol, after 120 days, everyone still only had fuzz in hair reduction areas. (Remember, The entirety of the top of Jason Statham's bald head has tons of fuzz, but he's still bald).

Yet in the group with DGLA and S-equol, after 120 days, everyone had grown thick robust shiny hair in hair reduction areas? None of it adds up. It genuinely makes no sense.

So in his accidental discovery that liposomal PGE1 grew hair, he discovered that liposomal DGLA does absolutely nothing for hair, but he replaced PGE1 with it anyway. But then he accidentally discovered that randomly adding equol made DGLA work better than PGE1 and grow thick hair, but apparently PGE1+equol does nothing but grow fuzz.

So say all of that is true. For the sake of the argument, let's say aesthetic density is 50follicles per mm. That means DGLA + Equol is over 50 times more effective than PGE1 + Equol. We're supposed to believe the coincidence that dgla + equol, where he said dgla does nothing on its own and that the addition of equol is an afterthought, is over 50 times more effective than his original discovery of PGE1, even with equol added.

I shouldn't have looked at the patent again. It's getting harder to stay positive.

Where in the patent does it say his original discovery contained just Pge1 +liposomes ?

 

[Ollie]

He says it in an interview, it's not stated directly in the patent, but it indirectly can be found in the patent by looking through the patent citations: Around 2010, he patented a formulation for treating circulation issues in the limbs of diabetics with PGE1 (a vasodilator) delivered by liposomes. During this, he noticed hair growth. He then applied for a new patent in ~2012-2013 with the same PGE1+liposome formula except with added equol. This was aimed at hair growth. Then around ~2013-2015 he applied for a new patent (the one he sold to Fidia) that had DGLA instead of PGE1, equol, and this time included extra stuff such as L-carnitine.

What's interesting is, after reading the interview again, he says:

"About 4 years ago we developed a lotion containing cationic liposomes that transported PGE1, S-equol and carnitine and we started testing it on people with androgenetic alopecia and on a later stage on a girl with alopecia areata. The results were great and unexpected."

But in the patent, the group using the lotion consisting of PGE1+S-equol only grew fuzz after 120 days... So that's another complete discrepancy. So yeah, I had given it being real maybe a 15% chance before, but it's down to a solid 2% now.

Yeah i see what you mean. Just having looked through the interview he mentions that originally the PGE1 had 'an affect on androgenic alopecia' - which i guess could mean very minimal and not cosmetic, until later ingredients were added - but who knows.

I'm still inclined to assume its a decent product simply cause its taking so long and its an actual drug company developing it - but again who the f*** knows. The thing recently that perked up my optimism was that the woman who has her daughter with Alopecia Areata posted that video on youtube, showing pictures she took of her when she was in the trials - which looked pretty amazing. I know its obviously not Androgenetic Alopecia but i'd like to think that it is at least symbolic of Brotzu being a man of his word. Lets just hope we find out this year.

 

[d3nt3dsh0v3l]

So let's just go over some stuff again.

Brotzu first discovered that just PGE1 delivered by liposomes caused unexpected hairgrowth on diabetic limbs. At this point, there was no equol or L-carnitine in the formula.

Then, he tries the precursor DGLA instead of PGE1 because PGE1 is a drug and would require trials in Europe. (Sidenote: In 1983, a patent application was made for a shampoo claiming that "the high linoleic acid content of the shampoo is very effective for preventing hair loss and developing or growing hair.")

Yet, in Brotzu's patent, it says the experimental group that used the solution containing only DGLA delivered by liposomes had no effect whatsoever on hair, despite his original discovery of only PGE1 delivered by liposomes causing hair growth, however he still intends for DGLA to replace PGE1.

However, for some magical reason, the arbitrary addition of small amounts of equol suddenly made the DGLA go from doing nothing to outperforming PGE1?

Yet in the experimental group with PGE1 and S-equol, after 120 days, everyone still only had fuzz in hair reduction areas. (Remember, The entirety of the top of Jason Statham's bald head has tons of fuzz, but he's still bald).

Yet in the group with DGLA and S-equol, after 120 days, everyone had grown thick robust shiny hair in hair reduction areas? None of it adds up. It genuinely makes no sense.

So in his accidental discovery that liposomal PGE1 grew hair, he discovered that liposomal DGLA does absolutely nothing for hair, but he replaced PGE1 with it anyway. But then he accidentally discovered that randomly adding equol made DGLA work better than PGE1 and grow thick hair, but apparently PGE1+equol does nothing but grow fuzz.

So say all of that is true. For the sake of the argument, let's say aesthetic density is 50follicles per mm. That means DGLA + Equol is over 50 times more effective than PGE1 + Equol. We're supposed to believe the coincidence that dgla + equol, where he said dgla does nothing on its own and that the addition of equol is an afterthought, is over 50 times more effective than his original discovery of PGE1, even with equol added.

I shouldn't have looked at the patent again. It's getting harder to stay positive.

I posted this exact thing like months ago .
It's no use. Haters gonna hate, brah.

Yeah I actually looked at their valuation once when trying to determine if they are legit or not.

As much as I want it to be real, I have my doubts about Brotzu's lotion. It's the equol that really bothers me. I've looked through the literature and tried to contact the people at Brigham Young University as they have published the most about equol's ability to bind to DHT and they also hold the key equol patent in the United States. No responses from them. They licensed equol use to NuSkin, a multilevel marketing company, which is a really f*****g shitty sign. One of the authors who appears on pretty much all the work has the same last name as a cofounder of NuSkin - lovely. And to top it off, both of them of course went to BYU. I learned all of this after digging around because I was wondering - why license equol to a company who wants to turn it into an anti-aging skin cream when acne and Androgenetic Alopecia are mentioned as potential applications in all of the literature and patents they wrote? Surely those are the high value problems to target. So I guess I have my doubts in its efficacy.

Several papers I read from the Japanese showed that there are probably some mild hormonal effects of equol that may alleviate post-menopausal hot flashes, some mild benign prostatic hyperplasia, etc. Soy is really popular in Japan and they seem to have no problem fermenting it to produce s-equol. What really bothered me is that the BYU work claims that equol binds very well to DHT yet studies by others who dose s-equol orally to patients saw only a mild decrease in serum DHT. The thing though, was that in these studies the equol concentration in the blood was several factors greater than the DHT concentration. If equol bound to DHT in a 1:1 manner and the binding affinity was high (as claimed by the BYU guys), I really expected that equol should tank serum DHT. Either that, or I should question the antibody used in ELISA to measure DHT concentration; I know that since sex hormone binding globulin binds to testosterone, different antibodies are used to measure free vs total testosterone to distinguish the unbound testosterone from the rest, so perhaps it may be tricky to distinguish equol-bound DHT from free DHT. I mean, SHGB is enormous and completely envelops testosterone whereas equol and DHT/testosterone are comparable in size. I don't know.

When I saw that Brotzu added equol to the lotion, I was initially excited (before I began to question the literature on equol). I mean, the idea made sense - PGE1 is a potent vasodilator and we know minoxidil works, and equol is supposed to suppress DHT's action on the androgen receptor as well as mildly agonize the estrogen receptor, both of which we know are important strategies toward recovering hair, as demonstrated by finasteride, RU-58841, as well as the estrogens that are taken by the trans community, who show exceptional regrowth.

But then Brotzu claimed that the two components don't work well by themselves, only together. This didn't make sense. Minoxidil and finasteride work just fine separately. Of course they work synergistically but they are not useless by themselves. Then I went and re-read Brotzu's patent carefully. Based on the experiments he ran, his conclusions suggested that actually, equol was doing the majority of the work in producing results. I was excited. This made sense. We know finasteride>minoxidil. But then, someone pointed out that there were amendments to the patent, the most important of which claimed that there was a typographical error in the patent, and that the formulation of one of the tested lotions was actually different from what was written on the patent. Acknowledging this change would actually reverse the conclusion and show that for whatever reason, neither the lotion containing PGE1 nor equol alone produced results. I thought that was peculiar - if they don't work separately, how could the professor possibly have known to combine them if he was initially just experimenting with PGE1 for diabetics? Wasn't the anecdote that topical PGE1 grew hair as a side effect? Didn't make sense.

The use of liposomes checks out to me. Not only as a means to effectively deliver drugs (ensuring proper penetration) but also as a means to selectively target the hair follicle; several papers have shown that this is possible.

So I was left wondering - is Brotzu legit? Some things make sense, but we know that to actually get results, we have to address DHT and the only thing in the lotion that appears to explicitly target DHT is equol, which unfortunately seems questionable based on what has been demonstrated in literature. Brotzu seems like a cool dude or whatever, being a professor at a university. But then again, so was the principle investigator from BYU who spent a big chunk of his career investigating equol's ability to bind to DHT and I am skeptical because of his association to NuSkin, etc. as I mentioned earlier. Why would Fidia purchase the patent to this lotion if it is useless? My close friend thinks that it probably works, since Fidia is not a very large company by any means and they don't have the capital to throw around on something that is a long shot or sketchy/garbage. Surely they saw some results for themselves before shelling out the dough to buy the patent. I don't know.

At this point, I wouldn't be shocked if it did NOT work and I would be surprised if it worked better than finasteride or hell, even matched finasteride results, because again, I think equol would have to be the thing that performs the antiandrogenic function. I would have preferred having the reverse attitude - shocked if it didn't work and expectant that it will match finasteride - but, whatever.

>inb4 dislikes just for questioning Brotzu's lotion. I don't give a f***. I will continue to evaluate things critically and objectively because it is the logical thing to do. We all know pictures and data are severely lacking. Also, nobody should be above being questioned. Feel free to question my claims/thoughts/conclusions also of course. I've learned many new things from people correcting me on this forum. If someone wants to show me that DGLA/PGE1 also exert antiandrogenic effects, that would make my day.

 

[NorwoodGuardian]

He says it in an interview, it's not stated directly in the patent, but it indirectly can be found in the patent by looking through the patent citations: Around 2010, he patented a formulation for treating circulation issues in the limbs of diabetics with PGE1 (a vasodilator) delivered by liposomes. During this, he noticed hair growth. He then applied for a new patent in ~2012-2013 with the same PGE1+liposome formula except with added equol. This was aimed at hair growth. Then around ~2013-2015 he applied for a new patent (the one he sold to Fidia) that had DGLA instead of PGE1, equol, and this time included extra stuff such as L-carnitine.

What's interesting is, after reading the interview again, he says:

"About 4 years ago we developed a lotion containing cationic liposomes that transported PGE1, S-equol and carnitine and we started testing it on people with androgenetic alopecia and on a later stage on a girl with alopecia areata. The results were great and unexpected."

But in the patent, the group using the lotion consisting of PGE1+S-equol only grew fuzz after 120 days... So that's another complete discrepancy. So yeah, I had given it being real maybe a 15% chance before, but it's down to a solid 2% now.

@Royaume Your view? I'd still be happy if it can regrow fuzz

 

[Johnt1997]

This thread is an absolute rollercoaster. Just when things were starting to look more positive again, with the patent update and the more recent brotzu interview, someone's comes out with this and pokes further holes in brotzu.

Really wish this would just be resolved one way or another, I can't take the torment anymore

 

[Ollie]

This thread is an absolute rollercoaster. Just when things were starting to look more positive again, with the patent update and the more recent brotzu interview, someone's comes out with this and pokes further holes in brotzu.

Really wish this would just be resolved one way or another, I can't take the torment anymore

Even worse knowing that this is literally the only thing that looks promising in regards to restoration for literally years and years..

 

[Toby0823]

If you had hopes for some lotion to help with your hairloss, then be prepared to be tormented for a very long time.

Italian hair lotion lmao

 

[Xander94]

Italian Hair Loss Lotion To Hit The Market In 2016

 

[Alternative]

So say all of that is true. For the sake of the argument, let's say aesthetic density is 50follicles per mm. That means DGLA + Equol is over 50 times more effective than PGE1 + Equol. We're supposed to believe the coincidence that dgla + equol, where he said dgla does nothing on its own and that the addition of equol is an afterthought, is over 50 times more effective than his original discovery of PGE1, even with equol added.
.

You could make a simple bomb from cleaning products, add one final ingredient and it explodes ripping your arm or head off. Don't add it, it stays the same.

Chemistry 101

Plus liposomal delivery or something like that which allows for better absorbtion.

 

[irishlad8787]

Brotzu Lotion definitive cure for androgenetic alopecia and ventilated?
MONDAY, FEBRUARY 19TH 2018 BY GIUSEPPE

For some years now we have been talking a lot about this lotion.

Its creator is Giovanni Brotzu, son of the famous Giuseppe Brotzu, a doctor who in 1945 contributed to the discovery of cephalosporins, antibiotics that ensured the treatment of diseases that were once incurable.

This lotion, according to Dr. Brotzu, would allow the regrowth of hair in the case of androgynous alopecia and ventilated, would be an incredible discovery and revolution, which would solve a widespread aesthetic problem throughout the world.

The doctor would have discovered it, as often happens in medicine by chance.

In fact, the doctor says:

We have started our studies to find a solution to some side effects of diabetes, specifically to micro-circulation defects, which cause bothersome and painful ulcers. The same that broadly trigger the degeneration of the hair bulbs "

This therapy, with cathode liposomes, is discovered, not only cured the lesions, but did regrow the hairs in the ulcerative area, which made immediately understand the doctor, who could also be used in cases of baldness and alopecia areata.

"We tested for the first time the lotion on a child and a nurse with whom we collaborated - says Brotzu - with excellent results. Over the last few years we have patented the lotion and sold the rights to the pharmaceutical company Fidia, to complete the studies. A decision made with the awareness that a structure suitable for the final experiment would have been useful. I, after all, am a surgeon and now I have a certain age, which allows me to leave the bulk of my work to others ".

The doctor has been interviewed by various newspapers and on the internet his interventions can be found.
For example, on youtube we report the following video:





As a result of all these events, many people have been mobilized to ask Fidia for the ready marketing of the lotion, given that Fidia herself, contrary to what was hoped, has repeatedly postponed marketing.

Here for example you find the signature collection link

https://www.change.org/p/efedeli-fi...ne-della-lozione-per-alopecia-del-prof-brotzu





But together with this enthusiasm, after many years of waiting, some doubts start to spread, one wonders why the photos of cases are few, because all this secrecy, if the product has been patented and is therefore covered by danger of copies?



For example, in a famous Italian forum, www.ieson.com, a very long debate has opened, which you can read in the following link



http://www.ieson.com/topic.asp?TOPIC_ID=66178



And if you have time to read the many discussions, some doubts about this lotion start to be credible. There are very few cases, many secrets and a lot of time lost.



It would therefore seem that on the one hand it is not possible to stabilize the lotion (for this reason the delay in its commercialization). But above all, it would seem, that it does not work as well as it was believed.



What to say, only with time (it had to be marketed in 2016 according to many) we will understand if we are facing an important turning point for the treatment of alopecia. Or in front of one of the many lotions pumped, but not very effective.



In our opinion the lotion, if stabilized, could be useful in cases of alopecia areata. Personally we do not believe it is important in terms of androgenetics, but they are sensations, not certainties.



For any news, stay in touch, we will publish the news here in the blog.








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• PUBLISHED IN PROSTHETIC HAIR

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Hair cloning, the future in the fight for alopecia and baldness?
MONDAY, FEBRUARY 19TH 2018 BY GIUSEPPE

Although it is natural to react with enthusiasm before the appearance of a novelty about probable solutions against baldness and hair loss, it is always good to be cautious and wait until you understand the true progress of these new procedures with greater depth.

The percentage of people suffering from alopecia is very high and the anxiety to resolve this problem once and for all causes the fact that any promising news on this subject is loaded with enormous expectations that often are not, unfortunately, maintained.

Surely it is true that this has a lot to do with the lack of scruples and respect that the companies that promote these innovations have towards people and their problem: they sell products that do not yet ensure anything as revolutionary and definitive and disregard their customers.



INQUIRE ABOUT:

We can only suggest to learn well and deepen their knowledge on the subject.
This is for any person who wants to start a new treatment before taking any alopecia medication.

So you can avoid missteps and take medicines that have been recognized as useless and harmful.

Enthusiasm and initial anxiety must be put on a brake. Then we must inform and eventually take advantage of the few but existing possibilities that exist in the market to combat alopecia.

Some simple readings will allow us to understand the difficulty of our problem and its size. And they will allow us not to waste time and money behind false illusions and unscrupulous charlatans.



Given these premises what is the cloning of the hair?

It is said that this innovative method is being studied in different countries of the world and that it will soon be possible to use it on humans.
It is simple: bulbs are lifted from the nape of the neck and with the method of cloning they multiply in the laboratory and are transplanted in the area affected by alopecia. Some are kept frozen in such a way that if baldness recurs there would be other bulbs to be cloned and then re-implanted.

This would allow large transplants even without having an important donor area and a nearly infinite number of bulbs.

Unfortunately, however, this method does not yet exist in the market and there are texts made on men.

So if someone advertises this method you are deceiving and is advertising a normal transplant. Do not fall into his scam and rely on honest doctors and clinics. They will sell you a method with its real name without using fancy phrases. If your alopecia is widespread and you want a perfect result, rely on newlacecu and its new generation hair implants www.newlacecu.it.


READ MORE

 

[irishlad8787]

Alot of people called giuseppe seem to talk about this lotion, this author not too optimistic about Androgenetic Alopecia but i guess he is just an author with an opinion.

 

[Alternative]

The article you linked is based on old info and IESON member discussions.
In it there is no info, just a collection of different opinions.

 

[irishlad8787]

yeah i kinda thought that just said i would post it anyway since it was published today.

 

[17AndBalding]

What was that Wu Wei guy using again? He had significant regrowth but I don't remember what he used.

 

[irishlad8787]

As far as i remember he was using some korean wounding technique and a form of the brotzu lotion homemade, im open to correction on that however, he deleted impressive pics he had put up on the ieson froum apparently and is now looking at manufacturing something himself.

 

[Armando Jose]

Brotzu first discovered that just PGE1 delivered by liposomes caused unexpected hairgrowth on diabetic limbs

Regarding hair growth, diabetic limbs are not even similar than scalp,