We don’t but that’s what he clamis in HairLossTalk.com and few italian forumsHow do we know that beeps is actually Brotzu son?
I saw in his posts here that he claimed to be friends of the family. He could very well be the son in hiding. He has insider info: HE posted the abstract for the Fidia studiesWe don’t but that’s what he clamis in HairLossTalk.com and few italian forums
An apple a day keeps the dermatologist away!Whatever happened to the magic apple pills that were supposed to be the new minoxidil 2.0?
I’ve always found him shady, but i’m sure in these 15k messages someone may have justified that he is the son of brotzu.I saw in his posts here that he claimed to be friends of the family. He could very well be the son in hiding. He has insider info: HE posted the abstract for the Fidia studies
You always come to this thread and post rabble rabble rabble, and i like thatRabble rabble rabble
Rabble rabble rabble
Do you have any clue about pharmacology at all?
Do you know what S-Equol is?
No, you don't.
If you did, you wouldn't even compare S-Equol with estrogen.
Pathetic!
Equol binds to circulating DHT where it is applied (in this case, scalp), preventing DHT from binding to the androgen receptor. We already knew that, I’ve said it in this thread so many times. Can you tell us how estrogen is different? I suspect it plays a role in preventing the formation of DHT right.
What?
Equol binds to DHT?
https://www.ncbi.nlm.nih.gov/m/pubmed/14681200/
Using binding assays, we determined that equol specifically binds 5alpha-dihydrotestosterone (DHT), but not testosterone, dehydroepiandrosterone, or estrogen with high affinity. Equol does not bind the prostatic androgen receptor, and has a modest affinity for recombinant estrogen receptor (ER) beta, and no affinity for ERalpha
It is interesting that the mechanism of its anti-androgen action differs from that of the anti-androgen drugs used in clinical practice to block the effects of DHT. For example, equol has no affinity for the an- drogen receptor (22) and therefore does not function as an an- drogen receptor blocker. It also does not appear to alter the synthesis of DHT in the way that 5 -reductase inhibitors do, but, rather, it appears to bind directly to DHT (22), and this effect is seen with both R- and S-equol (TD Lund, RJ Handa, ED Lephart, KDR Setchell, unpublished data, 2003).
If you notice, most of the haters of Brotzu are currently taking finasteride
Every time you back up your info with science, all the trolls don’t say sh*t until some brotion supporter say some wrong infos about science. It’s funny how science can keep their mouth shut lmao.Reading the posts in order:
And now the dude gets schooled another time
"You wouldn't compare S-Equol with estrogen"
View attachment 83259
View attachment 83262
View attachment 83260
View attachment 83261
(I Never said S Equol was a "proper" estrogen anyways, I just used the example of the topical estrogen to destroy the stupid bias that a topical can't regrow so much hair. S-Equol is indeed a "phytoestrogen" or a "plant estrogen", so it has selective estrogen features, it has an affinity for the estrogen receptor beta comparable to 17-beta-estradiol. I did not use the example to say that, but just because you attacked me in a rage, let's prove you wrong in your first quote: the estrogens bind to the estrogen receptors, S-Equol has an affinity to the estrogen receptor beta, so indeed it does act like an estrogen in this situation; plus it binds to DHT causing the formation of a compound that is no more able to bimd to the androgen receptor. In reality, I never meant to make a comparison between Equol and estrogens, I repeat that I used 17 beta estradiol to counter one of the stupidest point that cyclically gets repeated, then you made all by yourself not understanding a single f*** of my post, accusing me of a lack of knowledge and then getting schooled by the other users, LMAO)
( EDIT (4 teh lulz) : I just noticed it, it's funny that your profile pic is a group of goats. Here in Italy when someone is ignorant we call it "capra" which in fact means "goat". Perfect choice of your profile pic after what you posted, this is my reaction to your "What? Equol binds to DHT?"
lol remember that I have never said Equol is like an estrogen, never even compared the two, you could have argued differently, maybe saying "but Equol is not a estrogen therefore can't do their functions" and argued your point, with which I agree, Equol is not an estrogen and can't be compared with them in general terms, but instead you chose to go on full-retard mode, talked bullshit out of your ignorance, and being an a**h** with that Applemets phrase, and now you are taking the sh*t that you deserve!
Capra! Capra! Capra! Capra! )