lack of sleep and hair loss

[Armando Jose]

Yes, Ernie was a famous poster with the theory that body hair steal nutrients to scalp hair.....
Androgens, without doubt play a important key in hairloss but before the effect ofandrogens, exist some process that predispose certains hairs to loose.
OTOH there is problems to solve with androgens, the antagonism between body and scalp hair or the different incidence in women/men when the important androgens are produced in the same pilosebaceous unit.

 

[resu]

I thought about that too early on because I only experienced hair loss when more body hair started growing everywhere in my mid 20's, up until that point I didn't even have chest hair. It was like the body could only produce so much hair and some had to go, of course it isn't exactly like that.

 

[abcdefg]

I think genetics determines the receptors locations on all the different hairs and that as just a very simplified version is kind of what controls how fast or slow someone hair loss is along with of course androgen levels. So which hairs miniaturize is controlled by genetics which determine how many receptors and how they interact with the androgens which is where the sensitivity each hair has to them comes from. My opinion is people are over complicating the androgen step of male pattern baldness with tons of whacky theories to account for things which have simpler explanations.
Of course like in 8th grade we are told each atom has 8 still electrons, as you get older you realize they are actually probability clouds that move. These diseases are like that where it just gets more complex depending on how deep you want to go. DHT is just one tiny piece of it.

 

[Armando Jose]

abcdefg, do you think that genetics determines different hairs over the scalp? what Common Sense dictates at this aspect?

I am with you: "people are over complicating the androgen step of male pattern baldness with tons of whacky theories to account for things which have simpler explanations."

 

[abcdefg]

Well my personal opinion is the sensitivity of each hair is determined by genetics for hairs that are susceptible in the normal male pattern baldness pattern maybe with receptor layouts in scalp, but I think hairs can change their sensitivity to androgens over time such as developing more receptors or the existing receptors bind more strongly to left over androgens if say you took finasteride. I also think testosterone can miniaturize hair and if you lower DHT then T can take over in continuing the male pattern baldness process. I think upregulation or the receptors adapting to the remaining androgens does happen its just not completely understood yet why this is. The same thing seems to happen with prostate cancer so I think researchers are aware of this and its kind of the same problem they are trying to tackle. Just my opinion I dont know all current research on this

 

[Armando Jose]

Thanks abcdefg,....

I am with you "I think hairs can change their sensitivity to androgens over time"
but, I think that healthy scalp hairs are determined equally at first
I don´t think in the normal and genetic male pattern baldness pattern, I think that exist something, not genetic, that predisposse to certains hairs to be "more" sensitivity to androgens.

On the other hand, do you know if pilosebaceous units in scalp healthy hairs make androgens years before puberty?
Or in other words, do you think that prepubertal children have sebum in scalp hairs?

Thanks for your patience and willingness

 

[Scottzuh]

I have as since this past week.

 

[Armando Jose]

Thanks abcdefg,....

I am with you "I think hairs can change their sensitivity to androgens over time"
but, I think that healthy scalp hairs are determined equally at first
I don´t think in the normal and genetic male pattern baldness pattern, I think that exist something, not genetic, that predisposse to certains hairs to be "more" sensitivity to androgens.

On the other hand, do you know if pilosebaceous units in scalp healthy hairs make androgens years before puberty?
Or in other words, do you think that prepubertal children have sebum in scalp hairs?

Thanks for your patience and willingness

Dr. Kligman’s probe that exist sebum in hair scalp in childrens, years before puberty.

INHIBITION OF KERATIN FORMATION WITH UNSATURATED COMPOUNDS *
PETER FLESCII, M.D., Pa.D.

http://www.nature.com/jid/journal/v19/n5/pdf/jid1952109a.pdf

The author is greatly indebted to Dr. Donald M. Pillsbury for his constant interest and
encouragement in this work; to Dr. Raymond R. Suskind and the Procter and Gamble
company for their generous gift of samples of skin lipids extracted from T-Shirts; to Dr.
Stephen Rothman for a sample of a hair fat fraction; to Dr. Albert M. Kligman for the children's sebum

This fact put the actual androgenetic theory of hairloss questionable

 

[Yarkira]

I’ve noticed a connection between poor sleep and hair loss too. For me, getting quality sleep is tough. Waking up in the middle of the night doesn't help. I’ve also been dealing with diffuse thinning. I recently upgraded to a better mattress from view your deal, hoping it’ll help with both sleep and hair health.

 

[OtyMac]

More indicators of a vitamin d deficiency..​

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Sleep quality in men with androgenetic alopecia​

Sleep quality in men with androgenetic alopecia - PubMed

Our findings revealed an association between sleep disturbances and Androgenetic Alopecia, which may help guide appropriate management in these patients.

pubmed.ncbi.nlm.nih.gov

Conclusion: Our findings revealed an association between sleep disturbances and Androgenetic Alopecia, which may help guide appropriate management in these patients.

Obstructive sleep apnea, low transferrin saturation levels, and male-pattern baldness​

Obstructive sleep apnea, low transferrin saturation levels, and male-pattern baldness - PubMed

These findings suggest that OSA may be a risk factor for male pattern baldness in men who have a family history of hair loss and that low serum TSA levels associated with hypoxia may be involved in a pathway linking OSA and male pattern baldness.

pubmed.ncbi.nlm.nih.gov

Vitamin D supplements can have a positive effect on transferrin saturation, a marker of iron supply to tissues:

• Vitamin D supplementation and transferrin saturation
  A systematic review and meta-analysis found that vitamin D supplements had a positive effect on transferrin saturation.
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• Yes, vitamin D levels are linked to sleep quality:
  • Low vitamin D levels
    Studies show that low vitamin D levels are associated with poor sleep quality, shorter sleep duration, and more frequent nighttime awakenings.
  • 
    
  • Vitamin D receptors
    Vitamin D receptors are found in the brain regions that regulate sleep, such as the hypothalamus.
    
    
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  • Vitamin D and melatonin
    Vitamin D may play a role in regulating melatonin, the hormone that helps you sleep.
    
    
  • 
    
  • Vitamin D deficiency
    In the United States, about four out of 10 people have a vitamin D deficiency.
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  • 
    
  • There is a link between vitamin D deficiency and obstructive sleep apnea (OSA):
    • Vitamin D levels and OSA severity
      Vitamin D levels decrease as the severity of OSA increases. For example, in one study, the mean difference in 25(OH)D serum levels between controls and OSA patients was -2.7% for mild OSA, -10.1% for moderate OSA, and -17.4% for severe OSA.
    • 
      
    • Vitamin D deficiency and OSA in children
      A study of children with severe OSA found that 37.5% were deficient in vitamin D.
      
      
    • 
      
    • Vitamin D deficiency and OSA in adults
      Vitamin D deficiency is common in patients with OSA, and some studies suggest that vitamin D supplements can improve sleep quality and reduce OSA severity.
    Vitamin D is involved in regulating the sleep-wake cycle, and it affects how much melatonin the body produces. Vitamin D deficiency may also contribute to the pathogenesis of OSA by promoting inflammation, oxidative stress, hypoxia, and impaired immune and muscle function.
    
    
    However, it's unclear whether low vitamin D levels cause OSA or if OSA causes vitamin D deficiency. It's also possible that the association between vitamin D and OSA is due to body mass index (BMI).
    
    
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  • No variable has the explanatory power of vitamin D(NONE) and that includes androgens. DHT is actually increased to mitigate a vit D deficiency. IMO, the US is probably 90% deficient in vitamin D if you use the 50 ng/ml cutoff as what is recommended for optimal health.
  • Start here...
  • https://www.hairlosstalk.com/interact/threads/for-your-viewing-pleasure-vitamin-d-deficiency-hair-loss-a-case-report.139172/
  • IMO, there are only two groups of people;
  • 1) with an actual vit D deficiency(most of us)
  • 2)and others have perhaps enough vitamin d but have a vitamin d resistance like women can get at menopause.