Latest Patent from Dr. Cotsarelis

[hellouser]

Publication date: Dec 29, 2015
Filing date: Dec 15, 2011

https://www.google.com/patents/US9220926

FGF (not particularly FGF9, I cant find any info in the article) is administered 11 days after wounding;

Example 14Enhancement of EDIHN by Administration of FGFTo determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF.

I believe that's on mice. However;

In another embodiment, the present invention provides a method for treating an Androgenetic Alopecia in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an Androgenetic Alopecia in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

I was watching another video with Dr. Cotsarelis the other day, one of Desmond's recording's from last year's Hair Congress. This video specifically:

[video=youtube;m84cOOc8-T0]https://www.youtube.com/watch?v=m84cOOc8-T0[/video]

If you watch the presentation, you'll notice that FGF-9 is required for hair growth after wounding. However, FGF-9 is shown to be a precursor to WNT. Interestingly, Samumed's new topical works on WNT! So, could dermarolling along with Samumed's SM04554 actually lead to hair growth?

If only we knew which one of the three formula's is the CORRECT one they're using in the trials! More on Samumed here: http://www.hairlosstalk.com/interact/showthread.php/94997-Samumed-SM04554

 

[Norwood One]

Summary:
Mice have γδ T cells that produce FGF-9 after wounding, which is a precursor to WNT that causes a 3fold increase in follicular neogenesis.
Humans do not have as many γδ T cells, or they are arranged differently so wounding itself is useless in terms of hair growth.

As for addin Adding WNT:

“We’ve found that we can influence wound healing with wnts or other proteins that allow the skin to heal in a way that has less scarring and includes all the normal structures of the skin, such as hair follicles and oil glands, rather than just a scar,” explains Cotsarelis.
By introducing more wnt proteins to the wound, the researchers found that they could take advantage of the embryonic genes to promote hair-follicle growth, thus making skin regenerate instead of just repair.

Seems like WNT is used literally to generate a new hair follicle (along with sebaceous glands, etc), not wake up dormant hair follicles...

For that the wound would have to be pretty deep and invasive I assume?

 

[Seuxin]

Thats why we NEED wounding + SM no ? Byt the way, doesn't PGE2 induce FGF-9 too ?

 

[Tracksterderm]

This sounds really exciting!
From my limited knowledge, PGE2 does indeed induce FGF-9.

I am so looking forward to the results from the two trials for the Samumed SM04554:
https://clinicaltrials.gov/ct2/show/NCT02275351 (completed)
https://clinicaltrials.gov/ct2/show/study/NCT02503137 (ongoing)

 

[Baldybald1]

Great find !

Great find Hellouser and you are focusing on the right researcher, it is so tough to read his mind and his work but let's try to get as much info from him

 

[Solomon]

This thread should be more popular...

Hellouser I'm interested in your opinion. What do you think why Cotsarelis is so secretive? You've said that he doesn't give interviews and also didn't answer your questions...

 

[arfy]

Dr Cotsarelis was on a science TV show "Nova" in 1990 (along with Dr Christiano) about upcoming treatments for hair loss. I actually called Dr Cotsarelis and spoke with him for 5 minutes (in another thread I mentioned writing him a letter, but I remember now it was a phone call) at the University of Pennsylvania.

Over the next 25 years, I am certain that he has been bothered by hundreds of other guys like me, and realized that the more time he spends talking to people, the less time he has for work and personal life. I am sure that many people have called him while under great emotional stress, too (the "crazy" phone call).

What does he gain by giving interviews? He only gives tips to potential competitors (I'm sure that idea theft and sabotage are real issues) and he gets his name out among even more guys like me who will bother him at work (or at home, even worse).

 

[F2005]

Speaking of Desmond, we've really got to get him on here. I don't see him on BTT anymore. I wrote a few e-mails to the address he provided in the fundraising drive but did not get a response. His insight on here would be so extremely valuable.

 

[Solomon]

Dr Cotsarelis was on a science TV show "Nova" in 1990 (along with Dr Christiano) about upcoming treatments for hair loss. I actually called Dr Cotsarelis and spoke with him for 5 minutes (in another thread I mentioned writing him a letter, but I remember now it was a phone call) at the University of Pennsylvania.

Over the next 25 years, I am certain that he has been bothered by hundreds of other guys like me, and realized that the more time he spends talking to people, the less time he has for work and personal life. I am sure that many people have called him while under great emotional stress, too (the "crazy" phone call).

What does he gain by giving interviews? He only gives tips to potential competitors (I'm sure that idea theft and sabotage are real issues) and he gets his name out among even more guys like me who will bother him at work (or at home, even worse).

25 years of research and nothing valuable to patients... I'm not surprised if he doesn't get funding easily.

Do you think that he is working on something groundbreaking now?

 

[hellouser]

Speaking of Desmond, we've really got to get him on here. I don't see him on BTT anymore. I wrote a few e-mails to the address he provided in the fundraising drive but did not get a response. His insight on here would be so extremely valuable.

Winston, Spencer Kobren's moderator on the forum, has put Desmond84 into a semi-banned state. All his posts go through reviews before being approved.

Though to be fair, a LOT of members have been put into that state, myself included. Spencer Kobren doesn't respect it's forum members.

 

[F2005]

Winston, Spencer Kobren's moderator on the forum, has put Desmond84 into a semi-banned state. All his posts go through reviews before being approved.

Though to be fair, a LOT of members have been put into that state, myself included. Spencer Kobren doesn't respect it's forum members.

It doesn't surprise me. I think the BTT forum is just a vehicle for the hair transplant. That's why we've got to get Desmond on here. Do you know any other way to get in touch with him?

 

[Swoop]

It doesn't surprise me. I think the BTT forum is just a vehicle for the hair transplant. That's why we've got to get Desmond on here. Do you know any other way to get in touch with him?

He put up a message on btt and landed on his feet it seems;

Hahahaha uh man. I have so much love for this thread like you wouldn't believe. Lost is still the greatest show in my books.

I'm still around guys and check these threads regularly. Tbh, now that I'm a bit older and have seen how this industry operates I've kinda lowered my expectations a bit.

• Histogen is still making empty promises.
• Replicel still hasn't released their Phase I results that lasted 12 months! It was completed years ago. Those results would have confirmed the DHT immunity theory but they've chosen to keep it a secret!
• Aderans is gone.
• Samumed is going to face a mountain of hurdles imposed by FDA due to the Mechanism of action of their product. FDA will definitely wanna see a much longer trial to rule out carcinogenicity risks.
• Follicept failed to regrow lost hair.
• Follica is a ghost thinking it's still alive!
• Follicum ended up being similar to Minoxidil.
• Bimatoprost was unable to beat Minoxidil even at high doses.
• Tsuji labs is still saying 10 years like they did 4 years ago
• Lauster team still hasn't managed to create a fully functional hair follicle even with their microchip technology.
• JAK inhibitors are most probably just a hype. I can't see how suppressing your immune system would induce the 'First dermal signal' instructing epidermal cells to form a placode and ultimately a hair follicle. male pattern baldness patophysiology is completely different to Alopecia areata (autoimmune disorder).
• CB-03-01 is still 3-5 years away, and that's if the new company deems it profitable enough to release! I found out recently Cosmo pharmaceutical no longer exists

The truth of the matter: cure is still years away. If you don't halt your hair loss with finasteride or dutasteride then you will lose your hair. Sad times indeed.

That's my thoughts for tonight. 112 minutes is up and I've gotta run back to the hatch.

See you in another life brothers hopefully with a head full of hair

 

[farkhairloss]

Desmond is registered here as well. I dont think he posts as much these days. His username is HLT_Desmond84

http://www.hairlosstalk.com/interac...gs-looking-now-compared-to-10-years-ago/page2

 

[distracted]

He put up a message on btt and landed on his feet it seems;

He also just posted this:

The Chinese have mastered Jahoda's technique and are rapidly developing methods to take it to clinical trials. Here's the paper they published last month:

http://pubs.acs.org/doi/abs/10.1021/acsami.6b00202

Interestingly enough, DP cells maintained their Trichogenicity in passage 8 which is unheard of. Hair sprouted after expanding these cells 8 times. Let's see what more this year brings.

Important note: the DP cells used were human. They were just injected into mice! In before, another mouse study

And not sure where he read the Follicum = minoxidil in effectiveness. The charts in this post say otherwise.

http://www.folliclethought.com/follicum-results-vs-minoxidil-exclusive/

 

[I.D WALKER]

Desmond is a decent guy I'm sure and has done wonders to elevate BTT both insightfully and morally.

Does anyone know what his hair loss state/Norwood is today?

I think I read a couple years back he was not yet a NW2. A confirmation would be appreciated.

 

[nameless]

He also just posted this:



And not sure where he read the Follicum = minoxidil in effectiveness. The charts in this post say otherwise.

http://www.folliclethought.com/follicum-results-vs-minoxidil-exclusive/

Doesn't the Chinese discovery, if verified, mean male pattern baldness is cured? If the Chinese have found a way to maintain trichogenicity after 8 passages haven't they solved the key problem with DP cell implantation?

And how do the Chinese get around the multi-pass trichogenicity problem? What are the Chinese doing differently from what everyone else is doing? Nobody else can do 8 passages of DP cells and maintain
trichogenicity so if the Chinese can do it they must be doing something differently from what everyone else is doing since nobody else can do it. Does anyone have any idea what the Chinese are doing differently?

 

[Justinian]

He put up a message on btt and landed on his feet it seems;

Even if all the treatments are only as good as minoxidil when used alone, if the results are additive then getting 2 more side effect free treatments that compound with what we have is a functional cure.

 

[I.D WALKER]

Another good reason not to support Trump. Haha!
This pro- cultist blow bag will piss the Chinese off enough and consequently deny all U.S. Americans access to it.
I'm with you also in that I
predict they will be the at the forefront of a breakthrough hair loss solution,
but the truth is I personally don't give a damn who gets the credit
so long as we can ALL get our hands on it.

 

[distracted]

Another good reason not to support Trump. Haha!
This cultish blow bag will piss the Chinese off enough and consequently deny all U.S. Americans access to it.
I'm with you also in that I
predict they will be the at the forefront of a breakthrough hair loss solution,
but the truth is I personally don't give a damn who gets the credit
so long as we can ALL get our hands on it.

Can't support Clinton either after her remarks about the pharma industry.

http://money.cnn.com/2015/09/21/investing/hillary-clinton-biotech-price-gouging/

 

[firstpost]

Another good reason not to support Trump. Haha!
This cultish blow bag will piss the Chinese off enough and consequently deny all U.S. Americans access to it.
I'm with you also in that I
predict they will be the at the forefront of a breakthrough hair loss solution,
but the truth is I personally don't give a damn who gets the credit
so long as we can ALL get our hands on it.

They gonna refuse to take money from Americans because their feeling are hurt? Yeah right!