Hi everyone!i was searching a lot to find places that sell bimatoprost in a tablet form and i found two..its careprost(generic bimatoprost) and much cheaper and i am thinking of making a topical with the tablets..
http://209.85.229.132/search?q=cache:MP ... clnk&gl=gr
http://209.85.229.132/search?q=cache:Bk ... clnk&gl=gr
also i read this one: Scientists stumbled on the hair thickening properties of prostaglandin F 2? analogs while researching their use as an intraocular pressure (IOP)-lowering drug for use in patients with glaucoma and ocular hypertension. Prostaglandin F 2? analogs have the following general chemical structure wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration:
For example, latanoprost [(1R, 2R, 3R, 5S)3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopenty l]-5-heptenoate], marketed by Pfizer as Xalatan® is a prostaglandin analog in which R is H, B is —CH 2 —, n is 0, X is OCH(CH 3 ) 2 , and the dashed bonds represent a double bond. See U.S. Pat. No. 6,262,105, issued to Johnstone. Although Johnstone reported the stimulating effect of this drug on eyebrow and eyelash hair growth and pigmentation, Latanoprost works poorly on eyelashes.
Another example, is bimatoprost (cyclopentane N-ethyl heptenamide-5-cis-2-(3?-hydroxy-5-phenyl-1-trans-pentenyl)- 3,4-dihydroxy, [1 ? , 2 ? , 3 ? , 5 ? ], sold by Allergan, Inc. of Irvine, Calif. as Lumigan®, a 0.03% ophthalmic solution for treating glaucoma. Bimatoprost is a prostaglandin analog in which R is H, B is —CH 2 —, n is 0, X is NHC 2 H 5 and the dashed bonds represent a double bond (U.S. Published Application No. 2003/0147823). Bimatoprost, which also has been found effective to increase the growth of eyelashes when applied in the FDA approved manner, dissolves best for use on eyelashes but has negative side effects, such as, for example, redness and discoloration along the periocular skin; eye irritation; and foreign body sensation. In addition, bimtoprost has the highest incidence of hyperemia.
Another synthetic prostaglandin analog used for treatment of glaucoma is isopropyl (Z)-7-[(1 R ,2 R ,3 R ,5 S )-3,5-dihydroxy-2-[(1 E ,3 R )-3-hydroxy-4-[(?,?,?-trifluoro-m-tolyl)oxy]-1-butenyl]cy clopentyl]-5-heptenoate, or Travaprost (TRAVATAN® Alcon), which is available as a 0.004% ophthalmic solution. Travoprost is a prostaglandin analog in which R is H, B is O, Y is CF 3 , X is OCH(CH 3 ) 2 , and the dashed bonds represent a double bond. Travaprost does not work well for eyelash growth, taking longer than other like products.
Therefore it is an object of the present invention to provide prostaglandin analogs that will promote appropriate hair growth when applied topically to subjects in need thereof without causing significant undesirable side effects.
it says that travoprost and latanoprost dont work for eyelash growth..for latanoprost i read also about a study that happened for eyelash growth which 26 people applied latanoprost to their eyelashes and only one showed some results.. thats why i tried to find bimatoprost cause also dr bauman tested it but he said that they need to been done trials in higher concetrations...
your opinions please..
