Male Pattern Baldness And Prostate Cancer

[tjnpdx]

I know @ThatGuy recently made comment about a study (probably the study referenced in this article) about the correlation between male pattern baldness and prostate cancer, but I figured it was worth sharing. It seems odd that this correlation should be drawn and male pattern baldness should continue to be considered cosmetic and thought of as 'oh, that's just genetics for you,' when there are, apparently, obvious relationships between male pattern baldness and health ailments, especially cancer.

When I went to see a dermatologist to get a script for finasteride, he quite literally burst through the door without even introducing himself and proceeded to give me a speech on how it's the luck of the draw and sometimes you should just accept your fate. I post this mainly so that anyone going to see a dermatologist or doctor in the future regarding male pattern baldness can request that health care professional kindly go f*** off and study their science before they give you this disgraceful lecture.

This intimation of inherent androgen malfunction in balding men also makes me question the efficacy of some hair loss treatments considering none that I know of seek to actually target the androgen receptor in a holistic way; finasteride/dutasteride wouldn't make the cut for this. I'd like to have my hair back, regardless, but it will be great to eventually see a group actually go after, what is seemingly, the root of the problem, whenever the science permits.

http://www.medicalnewsbulletin.com/male-pattern-baldness-linked-higher-risk-prostate-cancer/

 

[InBeforeTheCure]

This intimation of inherent androgen malfunction in balding men also makes me question the efficacy of some hair loss treatments considering none that I know of seek to actually target the androgen receptor in a holistic way; finasteride/dutasteride wouldn't make the cut for this.

What do you mean by "target the androgen receptor in a holistic way"? Genetic knockdown of AR?

 

[tjnpdx]

What do you mean by "target the androgen receptor in a holistic way"? Genetic knockdown of AR?

I mean, if there is a problem with the way androgens and/or their receptors act, either alone or harmoniously, I look forward to any possible methods that seek to target this problem in a way that is deeply interconnected with the various components and acts via ways that aren't just plainly disruptive to the balance of hormones in males. Not to say this is something I imagine being easily accomplished. Perhaps holistic wasn't the ideal adjective there, but I simply mean in a way that specifically targets what the malfunction may be, rather than just inhibiting a hormone or two--a way that science is seemingly a bit far from uncovering, for the time being.

If males with male pattern baldness possess inherent disorders with the ways in which their androgens are metabolized, I think that a method that seeks to remedy this will be more profitable--to us with the problem--then growth stimulants or stem cell injections, which don't get to the root of the problem. That is not at all to say that I won't try to be one of the first ones in line for those treatments that effectively grow back hair, as this is something at the top of my list, but I merely mean in the long-term. Just dreaming, really.

 

[hanginginthewire]

Not that it matters but you @-ed the wrong ThatGuy. : )

 

[tjnpdx]

Not that it matters but you @-ed the wrong ThatGuy. : )

a-whoops

 

[InBeforeTheCure]

I mean, if there is a problem with the way androgens and/or their receptors act, either alone or harmoniously, I look forward to any possible methods that seek to target this problem in a way that is deeply interconnected with the various components and acts via ways that aren't just plainly disruptive to the balance of hormones in males. Not to say this is something I imagine being easily accomplished. Perhaps holistic wasn't the ideal adjective there, but I simply mean in a way that specifically targets what the malfunction may be, rather than just inhibiting a hormone or two--a way that science is seemingly a bit far from uncovering, for the time being.

If males with male pattern baldness possess inherent disorders with the ways in which their androgens are metabolized, I think that a method that seeks to remedy this will be more profitable--to us with the problem--then growth stimulants or stem cell injections, which don't get to the root of the problem. That is not at all to say that I won't try to be one of the first ones in line for those treatments that effectively grow back hair, as this is something at the top of my list, but I merely mean in the long-term. Just dreaming, really.

There's at least one topical AR antagonist (CB-03-01) and also topical finasteride in development, which are more "precise" and therefore helpful for maintaining in those who get sides from oral finasteride/dutasteride. And there are also black market chemicals of course. For regrowing a lot of hair though, it's far more likely IMO that cell-based methods will deliver before any chemical-based ones, as no chemical treatment in the pipeline right now has shown anything beyond mediocre regrowth. That's not to say that regrowth far beyond conventional treatments isn't possible. In fact, we know it is possible because transgenders taking estradiol and so on already achieve it. That unfortunately is not an option for the rest of us, because we want to grow hair, but not also tits.

I look forward to any possible methods that seek to target this problem in a way that is deeply interconnected with the various components

Yeah, I wish. But we're a loooooooooong way from understanding the molecular underpinnings of A.G.A, and at the current pace of research it will probably be mysterious for a long time yet to come.

 

[Gone]

Am I the only one confused about the idea that making hair androgen-independent will also nullify the androgen mechanisms that affect the prostate? The argument that replicel's RCH will have a medical effect on the prostate, and that this should be a reason for medical validation/urgency, makes no sense unless they also use the same RCH technology on the prostate, which so far is not in their pipeline.

 

[InBeforeTheCure]

Am I the only one confused about the idea that making hair androgen-independent will also nullify the androgen mechanisms that affect the prostate? The argument that replicel's RCH will have a medical effect on the prostate, and that this should be a reason for medical validation/urgency, makes no sense unless they also use the same RCH technology on the prostate, which so far is not in their pipeline.

Androgen-independent hair -> Less hair loss sufferers in the world -> Less depressed people -> More productive people -> Faster scientific and technological advancement -> Sooner a cure for prostate cancer

Q.E.D.

 

[Gone]

How could I not have forseen this, It's indisputable! Lol

 

[lemoncloak]

Cure for prostate cancer -> more sexually available men -> more procreation -> more dominant baldness genes -> more baldness
Looks like we need a cure for baldness

 

[Grasshüpfer]

Cure for prostate cancer -> more sexually available men -> more procreation -> more dominant baldness genes -> more baldness
Looks like we need a cure for baldness

I guess it's actually the other way round. Bald guys don't procreate.

 

[lemoncloak]

I guess it's actually the other way round. Bald guys don't procreate.

Of course they do. They just have to settle for less. Usually.
Sorry if I accidentally disliked my phone is being a jerk

 

[Christopher Hannah]

male pattern hair loss after cancer treatment is common behavior found.

 

[paleocapa89]

Also, some women lose hair in a male pattern way after on cancer treatment for breast cancer. What happens there? No DHT is involved I'd guess...

 

[That Guy]

When I went to see a dermatologist to get a script for finasteride, he quite literally burst through the door without even introducing himself and proceeded to give me a speech on how it's the luck of the draw and sometimes you should just accept your fate

I've told the story before on here how when I went to doctor's about it, I had to see 3 doctors before one told me there was anything that could be done. The first was some fat old b**ch who shrugged her shoulders at me and told me "ask the hairdresser to give you a haircut that will cover your forehead!" and the next was an old guy who said "It's one of those things".

The third guy said, "Medical science is not yet advanced enough to cure male-pattern baldness, but I can give you finasteride. It's a prostate drug that, in small doses, can preserve hair" and that's how I learned about it.

Anyway,

That article seems to be a bit different than the one I was thinking about because the one I brought up in the RepliCel thread also discussed increased risk of heart disease, but it also claimed that although there was a correlation, bald men were not necessarily at a significantly higher risk. However, a lot of studies have popped up that contradict that.

To me, it's baffling to me that for countless generations, pattern hairloss is seen as this "whatever" condition. You would think that the reaction to someone's hair falling out would be "holy sh*t, something's wrong" as would be the reaction with alopecia areata.

It only makes sense that with male pattern baldness — specifically significant baldness and/or APKH and at a young age — being a hereditary, genetic disorder that it probably brings other heredity, genetic disorders along with it.

 

[lemoncloak]

@Christopher Hannah @paleocapa89 cancer hair loss is because of chemo. The drugs they take stop multiplication of cells past a certain point which helps detain cancer. Hair works by stem cell renewal so it gets hit hard although I suppose your whole body feels sick bcos of them.
Of course, once you stop the meds the hair grows back.

 

[paleocapa89]

Taxotere is a cancer drug that can cause permanent hairloss in women, in a male pattern shape. What is astounding is that some of the women are suing the drug that saved their lives for hair loss. That's the impact of hairloss right there. But its not like we can sue our shitty genetics. XD

 

[Bushi]

My grandpa died of prostate cancer, he had a full head of hair.

 

[resu]

It's also linked to heart attack and other heart related issues, what's not to like about this condition?

Androgenetic Alopecia is said to progress in an orderly pattern with wide variation in individual patterns. Its clinical features have been described as recession of the frontal hair line leading to balding of the scalp vertex. The hair loss progresses up till only a rim of normal hair growth at the sides and back of the scalp remains. Gradual transition also occurs from large thick-pigmented terminal hairs to thinner, shorter, indeterminate hairs, and finally to non-pigmented vellus hairs in the involved areas when eventually hairs disappear completely. When hair loss is diffuse over the crown and frontal scalp with retention of the frontal hair line, it may resemble female pattern hair loss.[15] The HN classification is a method of clinically categorizing Androgenetic Alopecia.[1,2]

CAD is described as narrowing of coronary arteries supplying blood and oxygen to the heart which can slow down or stop due to plaque buildup of fatty material called atherosclerosis leading to chest pain, stable angina, shortness of breath, other symptoms, and heart attack.[16]

In this study, FH of both Androgenetic Alopecia and CAD was significantly high. The results were similar in previous studies.[5] There is higher frequency of balding in the fathers of bald men than in the fathers of non-bald men.[17] It is said that baldness has evolved in males through sexual selection as an enhanced signal of aging and social maturity. A variety of genetic and environmental factors are said to play a role in causing Androgenetic Alopecia. Androgen receptor gene which is X-linked recessive has been mentioned to be the cardinal prerequisite for balding but other genes are also involved. Genetic sensitivity of hair follicles to dihydrotestosterone (DHT) causes them to shrink when exposed to it.[18] 5-alphareductase is responsible for converting free testosterone (a major circulating androgen in men) into DHT.[15] Hair growth inhibitory factor-β, released from androgen-stimulated fibroblasts of the follicular dermal papilla may cause hair growth inhibition and hair follicle miniaturization, short lifespan, thereby preventing normal hair production.[19]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853891/

 

[NewUser]

So it makes even more sense for geneticists like Christiano, Fuchs, Jahoda et al to study the genetics of hairloss and along with that disorder, skin and prostate cancer and heart disease ; and which they've been doing for years.