Mast Cell Link To male pattern baldness ? Due To Low Uv Exposure

[Jk1]

if you want to base your understanding of one outlier thats fine.

i prefer to look at the averages and trends and what these new studies say. little do we know your brother maybe an outlier due to thyroid issues. or sure now he spends lots of time outside. but the question is in the years his male pattern baldness progressed how much sun was getting to his scalp ? was he indoors working or studying a lot ? or was he wearing hats to cover the hairloss and excacerbateing this issue?. haveing lots of scalp sun after you got advanced male pattern baldness will NOT reverse it alone ! the full dermarolling pg2 kotsarelis protocol would be needed as well as sun..

anyway main point is nothing to loose adding vit d topical as per studies. but where to get one with no prescription ? im adding vit d split pills now to my after dermaroling castor oil mix... not sure if its strong enough .. cod liver oil stinks and makes me feel sick so cannot use that..

 

[bassa]

Can you guys stop with this stupid theory? My brother spends like 4-8 hours in the sun daily and he is Norwood 5 at 2

Why is this just a stupid theory? Because your brother is bold... Even when he spents a lot of time outdoors... I believe there are a lot of factors in play here... This could be an important factor, next to other important factors, like allergies and dht...

People get cancer for a lot of different reasons (smoking, bad eating, uv, etc)... We know now (compared to 100 years ago) , we have a lot of types of cancers, they all need a slightly different approach of treatment... Some are curable others unfortunately not so much. I think this mechanism also applies for male pattern baldness.( we need to sub categorize male pattern baldness more than we do now)... Hence, why you see some treatments work for some and fail for others...

 

[Jk1]

so what we need is mast cell stabilizers.

vit d is one. cetrizine is another... both havr lots of new studies showing they help..

but the other interesting non drug one i found is qurcetin... i.e onion juice ! so this matches with thise youtuber they have regrowth on onion juice !

https://www.hairlosstalk.com/interact/threads/tablets-of-quercetin-and-pgd2-can-work.111173/

https://tophairlosstreatments.com/quercetin-hair-loss-natural-pgd2-inhibitor/

 

[whatevr]

Can you guys stop with this stupid theory? My brother spends like 4-8 hours in the sun daily and he is Norwood 5 at 25



Do you have any pictures? I've seen hundred of people claiming results from something without any proof. Just look at daro thread. Guy claimed success with that stuff ( no stuff ), people spent their money on it - not a single guy with positive results.

All I can show you is a picture of my current hair status:
https://s18.postimg.org/5j2t9me55/DSC_0016.jpg
And back on finasteride:
https://s18.postimg.org/x8zea8q15/finasteride.jpg

Different angle and combed differently, but that is all I have from the time period.

I haven't taken before/afters of the light because I did not really expect it to do anything. I haven't taken Finasteride since 2016 and don't really plan on ever again.

I will probably go on Setipiprant/Fevipiprant at some point, but for now this works for me and I intend to add more sh*t to stimulate growth factors and lower inflammation. But no antiandrogens.

 

[inmyhead]

A bit of thickening and just a bit of regrowth of the hairs that died most recently, yes. That also means maintenance, on nothing but these lights.

However for someone with really aggressive Androgenetic Alopecia it won't do it - you're gonna need more. But I would include it in every regimen, it has potential and probably works even better in combination with other things.

The bad thing about LLLT is that it reduces PGE2, so if you add that topically you can probably get all the benefits without any of the negatives.

All I can show you is a picture of my current hair status:
https://s18.postimg.org/5j2t9me55/DSC_0016.jpg
And back on finasteride:
https://s18.postimg.org/x8zea8q15/finasteride.jpg

Different angle and combed differently, but that is all I have from the time period.

I haven't taken before/afters of the light because I did not really expect it to do anything. I haven't taken Finasteride since 2016 and don't really plan on ever again.

I will probably go on Setipiprant/Fevipiprant at some point, but for now this works for me and I intend to add more sh*t to stimulate growth factors and lower inflammation. But no antiandrogens.

Thanks for posting pictures, finally someone who atleast tries to back up his claims. You have hair loss similiar to mine. About seti - theory seems nice - but looking at westonci's pics doesn't give much confidence if any.

Why is this just a stupid theory? Because your brother is bold... Even when he spents a lot of time outdoors... I believe there are a lot of factors in play here... This could be an important factor, next to other important factors, like allergies and dht...

People get cancer for a lot of different reasons (smoking, bad eating, uv, etc)... We know now (compared to 100 years ago) , we have a lot of types of cancers, they all need a slightly different approach of treatment... Some are curable others unfortunately not so much. I think this mechanism also applies for male pattern baldness.( we need to sub categorize male pattern baldness more than we do now)... Hence, why you see some treatments work for some and fail for others...

Because it doesn't make much sense. There are plenty of office workers who have spent many years and still have good hairlines. Also, why would taking finasteride/dutasteride suddenly reduce your need of sun?

 

[whatevr]

Thanks for posting pictures, finally someone who atleast tries to back up his claims. You have hair loss similiar to mine. About seti - theory seems nice - but looking at westonci's pics doesn't give much confidence if any.

On the latest pics that he posted on StopAGA (where he updates more frequently than here) he has new hairs that look terminal, growing all the way up to NW1. You can ask him for the pics.

PGD2 + PGE2 can maintain and give some regrowth, but it seems very slow, I think more growth factors are needed, and then it would really take off.

 

[bassa]

Because it doesn't make much sense. There are plenty of office workers who have spent many years and still have good hairlines.

Why are there people who smokes 2 packages of cigarettes a day never get lung cancer?

Also, why would taking finasteride/dutasteride suddenly reduce your need of sun?

Who says so? For instance, I'm a non responder to finasteride, also again, like many others.

This whole thing is a multi angle beast

 

[kiwipilu]

Whenever inventing a new theory, always ask yourself 'are there millions of people who disprove it as we speak?'

If yes, then whatever you think is a factor is clearly not anywhere near as much of an important factor in hair loss, or those people would not be balding.

So in other words, even if UV helps turn mast cells into something less bad, it's clearly not enough to overcome all the other factors of male pattern baldness as there are still so many baldheads in sunny countries. Case closed.

you can always argue. Maybe it's a factor for people who have predisposition to it... like always...
http://shared.web.emory.edu/emory/n...ith-health-of-blood-vessels.html#.WqzmUbhLFkg

 

[Jk1]

you can always argue. Maybe it's a factor for people who have predisposition to it... like always...
http://shared.web.emory.edu/emory/n...ith-health-of-blood-vessels.html#.WqzmUbhLFkg

genetics is a part of it as it was found their is differences in how our vit d receptors function and links to heart disease... i.e some peoples vit d receptors work properly others need more sun and a lot of help it seems ! i.e vit d receptor booster like sulphorophane and topical vit d

 

[Dennis Garber]

This thread is nearly impossible to read. Firstly, the op does not lay out anything clearly. At best, I think he is saying we need a few minutes of low sunlight per day to do something, of which it is not clear. Mass cells are both good and bad here. Vitamin D, something undefined as LLT .

Then cross talk about people pointing to equator baldness, which get way too much sun heat, pore clogging events that obviously lead to acne and hair loss in warm climate. These posts are way off topic .

Poorly laid out theory and crosstalk. The one guy with poor English ability who requested clarification was ignored. I think no one one this thread knows what this thread is about. Else, it would be laid out better, clearly.

 

[abcdefg]

There could be truth to this, but IMO men with male pattern baldness have something like defective vitamin D receptors and doesnt utilize the vitamin D correctly. Just because you get sun doesnt mean its converted and utilized by the hair correctly or the mast cells. I dont know enough about the interaction of different cell types, and the receptors though or the signalling between cells, and receptors.

 

[Jk1]

If this is true why would India have such high occurrence of Androgenetic Alopecia? You see men who start with incredibly thick hair (diameter and density wise) in India, some lose their hair very rapidly and some retain it for years. Everyone in India is getting a strong dose of sun, so clearly there is something else at play.

easily vit d defficiency is prevalent in suny places like india ! 70 percent of kids are low due to our indoor lifestyle and fear of skin cancer .
when vit d is probably the best anti cancer thing that exists.
https://www.ncbi.nlm.nih.gov/pubmed/24566435